Name: Name:L-755507
Brand: AABLOCKS
SKU: AA01E2D9
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA01E2D9

Chemical Name: L-755507

CAS Number: 159182-43-1

Molecular Formula: C30H40N4O6S

Molecular Weight: 584.7268

MDL Number: MFCD08703099

SMILES: CCCCCCNC(=O)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)CCNC[C@@H](COc1ccc(cc1)O)O

Properties

Complexity: 817

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Heavy Atom Count: 41

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 6

Rotatable Bond Count: 17

XLogP3: 4.3

Literature fold

Title: Do β3-adrenergic receptors play a role in guinea pig detrusor smooth muscle excitability and contractility?

Journal: American journal of physiology. Renal physiology20120115

Title: The selectivity of beta-adrenoceptor agonists at human beta1-, beta2- and beta3-adrenoceptors.

Journal: British journal of pharmacology20100701

Title: Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol protease.

Journal: Journal of medicinal chemistry20100114

Title: Promiscuous aggregate-based inhibitors promote enzyme unfolding.

Journal: Journal of medicinal chemistry20090409

Title: The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonyl]amino]-N-[4-[2-[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propyl]amino]ethyl]-phenyl]-benzenesulfonamide (L755507) and antagonist (S)-N-[4-[2-[[3-[3-(acetamidomethyl)phenoxy]-2-hydroxypropyl]amino]-ethyl]phenyl]benzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor.

Journal: Molecular pharmacology20081101

Title: Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice.

Journal: Circulation20011113

Title: (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists.

Journal: Journal of medicinal chemistry20010426

Title: 3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.

Journal: Bioorganic & medicinal chemistry letters19980818

Title: Epidemiology and infection control.

Journal: Dimensions in health service19751201

Title: Sato M, et al. The beta3-adrenoceptor agonist 4-[[(Hexylamino)carbonylamino-N---[[(2S)-2-hydroxy-3-(4-hydroxyphenoxy)propylaminoethyl-phenyl-benzenesulfonamide (L755507) and antagonist (S)-N---[--(acetamidomethyl)phenoxy-2-hydroxypropylamino-ethylphenylbenzenesulfonamide (L748337) activate different signaling pathways in Chinese hamster ovary-K1 cells stably expressing the human beta3-adrenoceptor. Mol Pharmacol. 2008 Nov;74(5):1417-28.

Title: Guoling Li, et al. Small molecules enhance CRISPR/Cas9-mediated homology-directed genome editing in primary cells. Sci Rep. 2017; 7: 8943.

Title: Murakami Y, et al. An effective double gene knock-in strategy using small-molecule L755507 in the medaka fish (Oryzias latipes). Genesis. 2022;60(1-2):e23465.

159182-43-1 | L-755507