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51050-59-0,MFCD00036960
Catalog No.:AA01E4J9

51050-59-0 | 3,4Dichloroisocoumarin

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1mg
98%
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$34.00   $24.00
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5mg
98%
in stock  
$74.00   $52.00
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10mg
98%
in stock  
$92.00   $64.00
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  • Technical Information
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  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E4J9
Chemical Name:
3,4Dichloroisocoumarin
CAS Number:
51050-59-0
Molecular Formula:
C9H4Cl2O2
Molecular Weight:
215.0329
MDL Number:
MFCD00036960
SMILES:
Clc1oc(=O)c2c(c1Cl)cccc2
NSC Number:
727363
Properties
Properties
 
Form:
Solid  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
273  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
XLogP3:
3.1  

Literature

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Title: Methicillin resistance alters the biofilm phenotype and attenuates virulence in Staphylococcus aureus device-associated infections.

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Title: An allosteric anti-hepsin antibody derived from a constrained phage display library.

Journal: Protein engineering, design & selection : PEDS 20120301

Title: Catalytic mechanism of rhomboid protease GlpG probed by 3,4-dichloroisocoumarin and diisopropyl fluorophosphonate.

Journal: The Journal of biological chemistry 20120127

Title: Multi-parametric analysis and modeling of relationships between mitochondrial morphology and apoptosis.

Journal: PloS one 20120101

Title: Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1.

Journal: PloS one 20120101

Title: Purification and characterization of a proteinase from the probiotic Lactobacillus rhamnosus OXY.

Journal: Preparative biochemistry & biotechnology 20120101

Title: Functions of rhomboid family protease RHBDL2 and thrombomodulin in wound healing.

Journal: The Journal of investigative dermatology 20111201

Title: Crystallization and preliminary X-ray diffraction studies of a complex of extracellular lipase from Streptomyces rimosus with the inhibitor 3,4-dichloroisocoumarin.

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20111101

Title: Evaluating antigen-specific cytotoxicity of CD8+ T cells in fish by granzyme B-like activity.

Journal: Veterinary immunology and immunopathology 20110515

Title: Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.

Journal: ACS chemical biology 20110415

Title: Nelfinavir induces liposarcoma apoptosis through inhibition of regulated intramembrane proteolysis of SREBP-1 and ATF6.

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Title: Apoptosis-like death in bacteria induced by HAMLET, a human milk lipid-protein complex.

Journal: PloS one 20110101

Title: An angiotensin I-converting enzyme mutation (Y465D) causes a dramatic increase in blood ACE via accelerated ACE shedding.

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Journal: BMC biology 20110101

Title: Noninvasive routes of proteins and peptides drug delivery.

Journal: Indian journal of pharmaceutical sciences 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Purification and characterization of a novel extracellular protease from a halo-alkaliphilic Bacillus sp. 17N-1, active in polar organic solvents.

Journal: Environmental technology 20100901

Title: Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation.

Journal: PloS one 20100101

Title: The structure and function of serum opacity factor: a unique streptococcal virulence determinant that targets high-density lipoproteins.

Journal: Journal of biomedicine & biotechnology 20100101

Title: Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition.

Journal: BMC developmental biology 20100101

Title: Endotoxin tolerance and cross-tolerance in mast cells involves TLR4, TLR2 and FcepsilonR1 interactions and SOCS expression: perspectives on immunomodulation in infectious and allergic diseases.

Journal: BMC infectious diseases 20100101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: The SGNH-hydrolase of Streptomyces coelicolor has (aryl)esterase and a true lipase activity.

Journal: Biochimie 20090301

Title: The effect of bafilomycin A1 and protease inhibitors on the degradation and recycling of a Class 5-mutant LDLR.

Journal: Acta biochimica et biophysica Sinica 20090301

Title: Inhibition of Mycobacterium tuberculosis secretory serine protease blocks bacterial multiplication both in axenic culture and in human macrophages.

Journal: Scandinavian journal of infectious diseases 20090101

Title: Camptothecin and khat (Catha edulis Forsk.) induced distinct cell death phenotypes involving modulation of c-FLIPL, Mcl-1, procaspase-8 and mitochondrial function in acute myeloid leukemia cell lines.

Journal: Molecular cancer 20090101

Title: Shedding of epidermal growth factor receptor is a regulated process that occurs with overexpression in malignant cells.

Journal: Experimental cell research 20081001

Title: Purification and enzymological characterization of murine neurotrypsin.

Journal: Protein expression and purification 20080901

Title: Identification of a potent, selective, and orally active leukotriene a4 hydrolase inhibitor with anti-inflammatory activity.

Journal: Journal of medicinal chemistry 20080724

Title: Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants.

Journal: PloS one 20080101

Title: Evidence for enhanced eNOS function in coronary microvessels during the second window of protection.

Journal: American journal of physiology. Heart and circulatory physiology 20070501

Title: Recombinant expression, purification, and kinetic and inhibitor characterisation of human site-1-protease.

Journal: Protein expression and purification 20070201

Title: Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131.

Journal: Antimicrobial agents and chemotherapy 20070201

Title: Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion.

Journal: Antimicrobial agents and chemotherapy 20070201

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Purification, primary structures and evolution of coagulant proteases from Deinagkistrodon actus venom.

Journal: Toxicon : official journal of the International Society on Toxinology 20051215

Title: The death receptor pathway is not involved in alloreactive T-cell induced mitochondrial membrane permeability.

Journal: Leukemia & lymphoma 20050801

Title: Chymotrypsin-like proteases contribute to human monocytic THP-1 cell as well as human microglial neurotoxicity.

Journal: Glia 20050701

Title: Expression and characterization of a serine protease that preferentially cleaves insulin-like growth factor binding protein-5.

Journal: Journal of cellular biochemistry 20050215

Title: Proteolytic cleavage of pertussis toxin S1 subunit is not essential for its activity in mammalian cells.

Journal: BMC microbiology 20050101

Title: Characterization of covalently inhibited extracellular lipase from Streptomyces rimosus by matrix-assisted laser desorption/ionization time-of-flight and matrix-assisted laser desorption/ionization quadrupole ion trap reflectron time-of-flight mass spectrometry: localization of the active site serine.

Journal: Journal of mass spectrometry : JMS 20041201

Title: ACE inhibitors and statins acutely improve endothelial dysfunction of human coronary arterioles.

Journal: American journal of physiology. Heart and circulatory physiology 20040401

Title: Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes.

Journal: Cell death and differentiation 20040201

Title: Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates.

Journal: Archives of biochemistry and biophysics 20040201

Title: Monoclonal LYM-1 antibody-dependent cytolysis by human neutrophils exposed to GM-CSF: auto-regulation of target cell attack by cathepsin G.

Journal: Journal of leukocyte biology 20040101

Title: Granzyme A mediates glucocorticoid-induced apoptosis in leukemia cells.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030901

Title: Characterization of a lysosomal serine carboxypeptidase from Trypanosoma cruzi.

Journal: Molecular and biochemical parasitology 20030901

Title: Cold-induced apoptosis of rat liver endothelial cells: involvement of the proteasome.

Journal: Transplantation 20030627

Title: Proteolytic activity of a yeast cell wall lytic Arthrobacter species.

Journal: Letters in applied microbiology 20030101

Title: Induction of tissue factor expression in human monocytic cells by protease inhibitors through activating activator protein-1 (AP-1) with phosphorylation of Jun-N-terminal kinase and p38.

Journal: Thrombosis research 20030101

Title: Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.

Journal: Planta 20020901

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Structure-activity relationship of hydroxamate-based inhibitors on the secretases that cleave the amyloid precursor protein, angiotensin converting enzyme, CD23, and pro-tumor necrosis factor-alpha.

Journal: Biochemistry 20020416

Title: Dipeptidyl peptidase with strict substrate specificity of an anaerobic periodontopathogen Porphyromonas gingivalis.

Journal: FEMS microbiology letters 20020319

Title: Epitope-specific antibody-induced cleavage of angiotensin-converting enzyme from the cell surface.

Journal: The Biochemical journal 20020315

Title: Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates.

Journal: European journal of biochemistry 20020101

Title: Proteasome inhibitors.

Journal: Progress in molecular and subcellular biology 20020101

Title: Mycosin-1, a subtilisin-like serine protease of Mycobacterium tuberculosis, is cell wall-associated and expressed during infection of macrophages.

Journal: BMC microbiology 20020101

Title: Purification and characterization of an extracellular trypsin-like protease of Fusarium oxysporum var. lini.

Journal: Journal of bioscience and bioengineering 20020101

Title: Cleavage of disulfide-bridged stalk domains during shedding of angiotensin-converting enzyme occurs at multiple juxtamembrane sites.

Journal: Biochemistry 20011225

Title: A simple assay for a human serum phospholipase A2 that is associated with high-density lipoproteins.

Journal: Journal of lipid research 20011001

Title: Caspase-dependent and serine protease-dependent DNA fragmentation of myocytes in the ischemia-reperfused rabbit heart: these inhibitors do not reduce infarct size.

Journal: Japanese circulation journal 20011001

Title: Human neutrophils employ the myeloperoxidase/hydrogen peroxide/chloride system to oxidatively damage apolipoprotein A-I.

Journal: European journal of biochemistry 20010601

Title: Effect of serine protease inhibitors on posttraumatic brain injury and neuronal apoptosis.

Journal: Experimental neurology 20010201

Title: Characterization of the stromal protease(s) degrading the cross-linked products of the D1 protein generated by photoinhibition of photosystem II.

Journal: Biochimica et biophysica acta 20010119

Title: Metabolism of prednisolone 21-acetate in hairless mouse skin.

Journal: Skin pharmacology and applied skin physiology 20010101

Title: Neuronal survival activity of s100betabeta is enhanced by calcineurin inhibitors and requires activation of NF-kappaB.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 19990901

Title: Synergy of amlodipine and angiotensin-converting enzyme inhibitors in regulating myocardial oxygen consumption in normal canine and failing human hearts.

Journal: The American journal of cardiology 19990617

Title: Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids.

Journal: Biochemistry 19930216

Title: Biochemical properties of the proteasome from Thermoplasma acidophilum.

Journal: European journal of biochemistry 19920915

Title: Peptidylglutamyl-peptide hydrolase activity of the multicatalytic proteinase complex: evidence for a new high-affinity site, analysis of cooperative kinetics, and the effect of manganese ions.

Journal: Biochemistry 19920428

Title: 3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex.

Journal: The Journal of biological chemistry 19920415

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