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929634-33-3,MFCD26936335
Catalog No.:AA01E5S9

929634-33-3 | ADAMTS-5Inhibitor

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$128.00   $89.00
- +
5mg
100%
in stock  
$333.00   $233.00
- +
25mg
100%
in stock  
$1,020.00   $714.00
- +
  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA01E5S9
Chemical Name:
ADAMTS-5Inhibitor
CAS Number:
929634-33-3
Molecular Formula:
C16H11ClF3N3OS3
Molecular Weight:
449.9212
MDL Number:
MFCD26936335
SMILES:
S=C1NC(=O)/C(=C/c2c(SCc3ccc(cc3)Cl)n(nc2C(F)(F)F)C)/S1
Properties
Computed Properties
 
Complexity:
626  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
5  

Literature

Title: Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge.

Journal: Bioorganic & medicinal chemistry 20081001

Title: 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: Gilbert AM, et al. 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1189-92.

Title: Wylie JD, et al. Adamts5 (aggrecanase-2) is widely expressed in the mouse musculoskeletal system and is induced in specific regions of knee joint explants by inflammatory cytokines. J Orthop Res. 2012 Feb;30(2):226-33.

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