[1]CurrentPatentAssignee:SUMMITTHERAPEUTICSPLC-US2009/48314,2009,A1Locationinpatent:Page/Pagecolumn6
[2]CurrentPatentAssignee:SUMMITTHERAPEUTICSPLC-WO2009/21748,2009,A2Locationinpatent:Page/Pagecolumn15-17
[3]Locationinpatent:experimentalpartChancellor,DanielR.;Davies,KayE.;DeMoor,Olivier;Dorgan,ColinR.;Johnson,PeterD.;Lambert,AdamG.;Lawrence,Daniel;Lecci,Cristina;Maillol,Carole;Middleton,PennyJ.;Nugent,Gary;Poignant,SéverineD.;Potter,AllysonC.;Price,PaulD.;Pye,RichardJ.;Storer,Richard;Tinsley,JonathonM.;VanWell,Renate;Vickers,Richard;Vile,Julia;Wilkes,FraserJ.;Wilson,FrancisX.;Wren,StephenP.;Wynne,GrahamM.[JournalofMedicinalChemistry,2011,vol.54,#9,p.3241-3250]
[1]CurrentPatentAssignee:SUMMITTHERAPEUTICSPLC-WO2017/168151,2017,A1Locationinpatent:Page/Pagecolumn18
[1]CurrentPatentAssignee:SUMMITTHERAPEUTICSPLC-WO2017/168151,2017,A1
Title: Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy.
Journal: Journal of medicinal chemistry 20110512
Title: Importance of the aromatic ring in adrenergic amines. 2. Synthesis and adrenergic activity of some nonaromatic six- and eight-membered ring analogs of beta-phenylethanolamine.
Journal: Journal of medicinal chemistry 19760101
Title: Chancellor DR, et al. Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy. J Med Chem. 2011;54(9):3241-3250.
Title: Chatzopoulou M, et al. Isolation, Structural Identification, Synthesis, and Pharmacological Profiling of 1,2-trans-Dihydro-1,2-diol Metabolites of the Utrophin Modulator Ezutromid. J Med Chem. 2020;63(5):2547-2556.
Title: Tinsley JM et al. Daily treatment with SMTC1100, a novel small molecule utrophin upregulator, dramatically reduces the dystrophic symptoms in the mdx mouse. PLoS One. 2011 May 6;6(5):e19189.
Title: Tinsley J et al. Safety, tolerability, and pharmacokinetics of SMT C1100, a 2-arylbenzoxazole utrophin modulator, following single- and multiple-dose administration to healthy male adult volunteers. J Clin Pharmacol. 2015 Jun;55(6):698-707.
Title: Guiraud S et al. Second-generation compound for the modulation of utrophin in the therapy of DMD. Hum Mol Genet. 2015 Aug 1;24(15):4212-24.
