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Home Other Building Blocks 1323403-33-3
1323403-33-3,MFCD31382133
Catalog No.:AA01EAYT

1323403-33-3 | CC-220

Pack Size
Purity
Availability
Price(USD)
Quantity
  
2mg
98%
in stock  
$28.00   $20.00
- +
5mg
98%
in stock  
$68.00   $48.00
- +
25mg
98%
in stock  
$270.00   $189.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01EAYT
Chemical Name:
CC-220
CAS Number:
1323403-33-3
Molecular Formula:
C25H27N3O5
Molecular Weight:
449.4990
MDL Number:
MFCD31382133
SMILES:
O=C1CC[C@@H](C(=O)N1)N1Cc2c(C1=O)cccc2OCc1ccc(cc1)CN1CCOCC1
Properties
Computed Properties
 
Complexity:
732  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
1.1  

Literature

Title: A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos.

Journal: Journal of medicinal chemistry 20180125

Title: Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4.

Journal: Blood cancer journal 20151001

Title: Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population.

Journal: PloS one 20140101

Title: Chad C Bjorklund, et al. Iberdomide (CC-220) is a potent cereblon E3 ligase modulator with antitumor and immunostimulatory activities in lenalidomide- and pomalidomide-resistant multiple myeloma cells with dysregulated CRBN. Leukemia. 2020 Apr;34(4):1197-1201.

Title: Erin W Meermeier, et al. Tumor burden limits bispecific antibody efficacy through T cell exhaustion averted by concurrent cytotoxic therapy. Blood Cancer Discov. 2021 Jul;2(4):354-369.

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Tags:1323403-33-3 Molecular Formula|1323403-33-3 MDL|1323403-33-3 SMILES|1323403-33-3 CC-220