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927961-18-0,MFCD31619253
Catalog No.:AA01EAZ7

927961-18-0 | Lanifibranor

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
99+%
in stock  
$35.00   $25.00
- +
5mg
99+%
in stock  
$60.00   $42.00
- +
10mg
99+%
in stock  
$77.00   $54.00
- +
50mg
99+%
in stock  
$131.00   $92.00
- +
250mg
95%
in stock  
$470.00   $329.00
- +
1g
95%
in stock  
$1,443.00   $1,010.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EAZ7
Chemical Name:
Lanifibranor
CAS Number:
927961-18-0
Molecular Formula:
C19H15ClN2O4S2
Molecular Weight:
434.9164
MDL Number:
MFCD31619253
SMILES:
OC(=O)CCCc1cc2c(n1S(=O)(=O)c1ccc3c(c1)scn3)ccc(c2)Cl
Properties
Computed Properties
 
Complexity:
686  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
6  
XLogP3:
4.5  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2018,vol.61,#6,p.2246-2265

[1]JournalofMedicinalChemistry,2018,vol.61,#6,p.2246-2265

[1]JournalofMedicinalChemistry,2018,vol.61,#6,p.2246-2265

Downstream Synthesis Route

[1]JournalofMedicinalChemistry,2018,vol.61,p.2246-2265

N-(4-chloro-2-iodophenyl)-1,3-benzothiazole-6-sulfonamide 
  927961-18-0 

[1]JournalofMedicinalChemistry,2018,vol.61,p.2246-2265

[1]JournalofMedicinalChemistry,2018,vol.61,p.2246-2265

[1]JournalofMedicinalChemistry,2018,vol.61,p.2246-2265

Literature

Title: Boubia B, et al. Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate. J Med Chem. 2018 Feb 27.

Title: Ruzehaji N, et al. Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis. Ann Rheum Dis. 2016 Dec;75(12):2175-2183.

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