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1011244-68-0,MFCD12463359
Catalog No.:AA01EAZU

1011244-68-0 | Tfap

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
97%
in stock  
$9.00   $7.00
- +
5mg
97%
in stock  
$23.00   $16.00
- +
10mg
97%
in stock  
$33.00   $23.00
- +
25mg
97%
in stock  
$54.00   $38.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EAZU
Chemical Name:
Tfap
CAS Number:
1011244-68-0
Molecular Formula:
C13H10F3N3O
Molecular Weight:
281.2332
MDL Number:
MFCD12463359
SMILES:
Nc1ccc(nc1)NC(=O)c1ccc(cc1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
340  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
2  
XLogP3:
2.2  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2008,vol.51,#8,p.2400-2411

[2]Patent:EP2070908,2009,A1,.Locationinpatent:Page/Pagecolumn9-10

[1]Patent:EP2070908,2009,A1,

[1]Patent:EP2070908,2009,A1,

Literature

Title: [Significance and creation of novel cyclooxygenase-1 (COX-1) selective inhibitors].

Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110301

Title: Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20100315

Title: Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor.

Journal: Journal of medicinal chemistry 20080424

Title: Kakuta H, et al. Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1840-3.

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SDS
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