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Home Deuterated Building Blocks 1609392-27-9
1609392-27-9,MFCD31715455
Catalog No.:AA01EO3B

1609392-27-9 | Tyk2-IN-4

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$63.00   $44.00
- +
25mg
98%
in stock  
$224.00   $157.00
- +
100mg
98%
in stock  
$517.00   $362.00
- +
1g
98%
in stock  
$1,714.00   $1,200.00
- +
  • Technical Information
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA01EO3B
Chemical Name:
Tyk2-IN-4
CAS Number:
1609392-27-9
Molecular Formula:
C20H19D3N8O3
Molecular Weight:
425.4590
MDL Number:
MFCD31715455
SMILES:
COc1c(cccc1c1ncn(n1)C)Nc1cc(nnc1C(=O)NC([2H])([2H])[2H])NC(=O)C1CC1
Properties
Computed Properties
 
Complexity:
648  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
3  
Rotatable Bond Count:
7  
XLogP3:
1.2  

Literature

Title: Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.

Title: Catlett I, et al. SAT0226 A first-in-human, study of BMS-986165, a selective, potent, allosteric small molecule inhibitor of tyrosine kinase 2. Annals of the Rheumatic Diseases 2017;76:859.

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Tags:1609392-27-9 Molecular Formula|1609392-27-9 MDL|1609392-27-9 SMILES|1609392-27-9 Tyk2-IN-4