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Home Other Building Blocks 1898283-02-7
1898283-02-7,MFCD31619238
Catalog No.:AA01EO3V

1898283-02-7 | LY3200882

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$27.00   $19.00
- +
5mg
98%
in stock  
$65.00   $46.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01EO3V
Chemical Name:
LY3200882
CAS Number:
1898283-02-7
Molecular Formula:
C24H29N5O3
Molecular Weight:
435.5188
MDL Number:
MFCD31619238
SMILES:
CC(c1nccc(c1)Nc1nccc(c1)Oc1cn(nc1C1CCOCC1)C1CC1)(O)C
Properties
Computed Properties
 
Complexity:
612  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
7  
XLogP3:
2.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:ELILILLY&CO-US2016/96823,2016,A1Locationinpatent:Paragraph0099-0100

[1]CurrentPatentAssignee:ELILILLY&CO-US2016/96823,2016,A1Locationinpatent:Paragraph0102-0103

[1]CurrentPatentAssignee:ELILILLY&CO-US2016/96823,2016,A1Locationinpatent:Paragraph0105-0106

[1]CurrentPatentAssignee:ELILILLY&CO-US2016/96823,2016,A1Locationinpatent:Paragraph0083-0084

[1]CurrentPatentAssignee:ELILILLY&CO-US2016/96823,2016,A1

[2]CurrentPatentAssignee:ELILILLY&CO-US2016/96823,2016,A1

Literature

Title: Huaxing Pei, et al. Abstract 955: LY3200882, a novel, highly selective TGFβRI small molecule inhibitor. AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 955.

Title: Xu G, et al. Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors. Eur J Med Chem. 2020 Apr 29;198:112354.

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