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1253186-56-9,MFCD28411366
Catalog No.:AA01EOGL

1253186-56-9 | GSK-7975A

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$104.00   $73.00
- +
100mg
98%
1 week  
$123.00   $86.00
- +
250mg
98%
1 week  
$207.00   $145.00
- +
1g
98%
1 week  
$558.00   $391.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EOGL
Chemical Name:
GSK-7975A
CAS Number:
1253186-56-9
Molecular Formula:
C18H12F5N3O2
Molecular Weight:
397.2988
MDL Number:
MFCD28411366
SMILES:
Oc1ccc(c(c1)C(F)(F)F)Cn1ccc(n1)NC(=O)c1c(F)cccc1F
Properties
Computed Properties
 
Complexity:
540  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
3.7  

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn100

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn97

1253186-56-9   
3-(bromomethyl)pyridinehydrobromide 
  76-05-1    1253186-60-5 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn97-98

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn98

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn98-99

Literature

Title: Blockade of store-operated calcium entry alleviates ethanol-induced hepatotoxicity via inhibiting apoptosis.

Journal: Toxicology and applied pharmacology 20150815

Title: Ashmole I, et al. CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2.

Title: Rice LV, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.

Title: Wen L, et al. Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015 Aug;149(2):481-92.e7.

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SDS
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Tags:1253186-56-9 Molecular Formula|1253186-56-9 MDL|1253186-56-9 SMILES|1253186-56-9 GSK-7975A
Catalog No.: AA01EOGL
1253186-56-9,MFCD28411366
1253186-56-9 | GSK-7975A
Pack Size： 1mg
Purity： 95%
1 week
$104.00 $73.00
Pack Size： 100mg
Purity： 98%
1 week
$123.00 $86.00
Pack Size： 250mg
Purity： 98%
1 week
$207.00 $145.00
Pack Size： 1g
Purity： 98%
1 week
$558.00 $391.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01EOGL
Chemical Name: GSK-7975A
CAS Number: 1253186-56-9
Molecular Formula: C18H12F5N3O2
Molecular Weight: 397.2988
MDL Number: MFCD28411366
SMILES: Oc1ccc(c(c1)C(F)(F)F)Cn1ccc(n1)NC(=O)c1c(F)cccc1F
Properties
Complexity: 540  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 28  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 4  
XLogP3: 3.7  
Downstream Synthesis Route
1253186-56-9    6482-24-2    1253186-64-9 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn100

1253186-56-9    73870-24-3    76-05-1    1253186-58-1 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn97

1253186-56-9   
3-(bromomethyl)pyridinehydrobromide 
  76-05-1    1253186-60-5 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn97-98

1253186-56-9    74-88-4    1253186-61-6 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn98

2969-81-5    1253186-56-9    1253186-62-7 

[1]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2010/122089,2010,A1Locationinpatent:Page/Pagecolumn98-99

Literature fold

Title: Blockade of store-operated calcium entry alleviates ethanol-induced hepatotoxicity via inhibiting apoptosis.

Journal: Toxicology and applied pharmacology20150815

Title: Ashmole I, et al. CRACM/Orai ion channel expression and function in human lung mast cells. J Allergy Clin Immunol. 2012 Jun;129(6):1628-35.e2.

Title: Rice LV, et al. Characterization of selective Calcium-Release Activated Calcium channel blockers in mast cells and T-cells from human, rat, mouse and guinea-pig preparations. Eur J Pharmacol. 2013 Mar 15;704(1-3):49-57.

Title: Wen L, et al. Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology. 2015 Aug;149(2):481-92.e7.

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