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1642288-47-8,MFCD31746877
Catalog No.:AA01EOKL

1642288-47-8 | Mavacamten

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$89.00   $62.00
- +
5mg
≥98%
in stock  
$216.00   $151.00
- +
10mg
100%
in stock  
$323.00   $226.00
- +
25mg
99%
in stock  
$640.00   $448.00
- +
50mg
100%
in stock  
$991.00   $694.00
- +
100mg
99%
in stock  
$1,807.00   $1,265.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EOKL
Chemical Name:
Mavacamten
CAS Number:
1642288-47-8
Molecular Formula:
C15H19N3O2
Molecular Weight:
273.3303
MDL Number:
MFCD31746877
SMILES:
C[C@@H](c1ccccc1)Nc1cc(=O)n(c(=O)[nH]1)C(C)C
Properties
Computed Properties
 
Complexity:
411  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
4  
XLogP3:
2.1  

Downstream Synthesis Route

[1]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2022/162701,2022,A1Locationinpatent:Page/Pagecolumn19;20

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1Locationinpatent:Paragraph0074-0075

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/28360,2019,A1Locationinpatent:Paragraph0193

[4]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2021/92598,2021,A1Locationinpatent:Paragraph570

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1Locationinpatent:Paragraph0075-0076

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1Locationinpatent:Paragraph0076-0077

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1

Literature

Title: Kawas RF, et al. A small-molecule modulator of cardiac myosin acts on multiple stages of the myosin chemomechanical cycle. J Biol Chem. 2017 Oct 6;292(40):16571-16577.

Title: Stern JA, et al. A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy. PLoS One. 2016 Dec 14;11(12):e0168407.

Title: Green EM, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 5;351(6273):617-21.

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SDS
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Tags:1642288-47-8 Molecular Formula|1642288-47-8 MDL|1642288-47-8 SMILES|1642288-47-8 Mavacamten
Catalog No.: AA01EOKL
1642288-47-8,MFCD31746877
1642288-47-8 | Mavacamten
Pack Size： 1mg
Purity： ≥98%
in stock
$89.00 $62.00
Pack Size： 5mg
Purity： ≥98%
in stock
$216.00 $151.00
Pack Size： 10mg
Purity： 100%
in stock
$323.00 $226.00
Pack Size： 25mg
Purity： 99%
in stock
$640.00 $448.00
Pack Size： 50mg
Purity： 100%
in stock
$991.00 $694.00
Pack Size： 100mg
Purity： 99%
in stock
$1,807.00 $1,265.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA01EOKL
Chemical Name: Mavacamten
CAS Number: 1642288-47-8
Molecular Formula: C15H19N3O2
Molecular Weight: 273.3303
MDL Number: MFCD31746877
SMILES: C[C@@H](c1ccccc1)Nc1cc(=O)n(c(=O)[nH]1)C(C)C
Properties
Complexity: 411  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 4  
XLogP3: 2.1  
Downstream Synthesis Route
887581-47-7    2627-86-3    1642288-47-8 

[1]CurrentPatentAssignee:DRREDDY'SLABORATORIESLIMITED-WO2022/162701,2022,A1Locationinpatent:Page/Pagecolumn19;20

[2]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1Locationinpatent:Paragraph0074-0075

[3]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2019/28360,2019,A1Locationinpatent:Paragraph0193

[4]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2021/92598,2021,A1Locationinpatent:Paragraph570

1642288-47-8    1642288-48-9 

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1Locationinpatent:Paragraph0075-0076

1642288-47-8    1642288-49-0 

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1Locationinpatent:Paragraph0076-0077

69998-14-7    1642288-47-8 

[1]CurrentPatentAssignee:BRISTOL-MYERSSQUIBBCO-WO2014/205223,2014,A1

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