Home Other Building Blocks 432001-19-9
432001-19-9,MFCD03141581
Catalog No.:AA01FSFS

432001-19-9 | C188-9

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$125.00   $87.00
- +
10mg
≥98%
in stock  
$222.00   $155.00
- +
25mg
≥98%
in stock  
$488.00   $341.00
- +
50mg
≥98%
in stock  
$729.00   $510.00
- +
100mg
98%
in stock  
$1,457.00   $1,020.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA01FSFS
Chemical Name:
C188-9
CAS Number:
432001-19-9
Molecular Formula:
C27H21NO5S
Molecular Weight:
471.5243
MDL Number:
MFCD03141581
SMILES:
COc1ccc(cc1)S(=O)(=O)Nc1cc(c(c2c1cccc2)O)c1c(O)ccc2c1cccc2
Properties
Computed Properties
 
Complexity:
776  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
5  
XLogP3:
5.8  

Downstream Synthesis Route
432001-19-9   
C27H19NO5S 

[1]Patent:WO2019/204614,2019,A1.Locationinpatent:Paragraph0252;0257

[1]Patent:WO2019/204614,2019,A1

[1]Patent:WO2019/204614,2019,A1

Literature

Title: Silva KA, et al. Inhibition of Stat3 activation suppresses caspase-3 and the ubiquitin-proteasome system, leading to preservation of muscle mass in cancer cachexia. J Biol Chem. 2015 Apr 24;290(17):11177-87.

Title: Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26;117(21):5701-9.

Title: Bharadwaj U, et al. Small-molecule inhibition of STAT3 in radioresistant head and neck squamous cell carcinoma. Oncotarget. 2016 May 3;7(18):26307-30.

Title: Redell MS, et al. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011;117(21):5701-5709.

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SDS
Tags:432001-19-9 Molecular Formula|432001-19-9 MDL|432001-19-9 SMILES|432001-19-9 C188-9