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101831-37-2,MFCD00867203
Catalog No.:AA0005LQ
101831-37-2 | Benzeneacetonitrile, 2,6-dichloro-α-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-
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  • Technical Information
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Technical Information
Catalog Number:
AA0005LQ
Chemical Name:
Benzeneacetonitrile, 2,6-dichloro-α-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-
CAS Number:
101831-37-2
Molecular Formula:
C17H9Cl3N4O2
Molecular Weight:
407.6380
MDL Number:
MFCD00867203
IUPAC Name:
2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile
InChI:
InChI=1S/C17H9Cl3N4O2/c18-10-3-1-9(2-4-10)12(7-21)16-13(19)5-11(6-14(16)20)24-17(26)23-15(25)8-22-24/h1-6,8,12H,(H,23,25,26)
InChI Key:
ZSZFUDFOPOMEET-UHFFFAOYSA-N
SMILES:
N#CC(c1c(Cl)cc(cc1Cl)n1ncc(=O)[nH]c1=O)c1ccc(cc1)Cl
NSC Number:
759642
Properties
Computed Properties
 
Complexity:
629  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
405.979g/mol
Formal Charge:
0
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
407.635g/mol
Monoisotopic Mass:
405.979g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
85.6A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
4.1  

Synonyms
 
2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile 
Clinacox 
NCGC00168785-01 
R64,433 
R 64433 
(p-Chlorophenyl)(2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-as-triazin-2(3H)-yl)phenyl)acetonitrile 
DCL 
(p-chlorophenyl)[2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-as-triazin-2(3H)-yl)phenyl]acetonitrile 
2,6-Dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benz-eneacetonitrile 
Benzeneacetonitrile, 2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)- 
R-64433 
Diclazurilo 
Diclazurilum 
2,6-Dichloro-alpha-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl]benzeneacetonitrile 
2-(4-chlorophenyl)-2-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenyl)acetonitrile 
SR-05000001484 
Nuoqiu 
Diclazuril [USAN:USP:INN:BAN] 
(4-chlorophenyl)[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3H)-yl)phenyl]acetonitrile 
diclazuril 
2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile 
AC1L9UTR 
Diclazuril (USAN/INN) 
DSSTox_CID_26787 
DSSTox_RID_81905 
DSSTox_GSID_46787 
SCHEMBL126138 
CHEMBL284733 
DTXSID4046787 
CHEBI:95118 
R 64433 
ZSZFUDFOPOMEET-UHFFFAOYSA-N 
HMS2089N18 
HMS3655D11 
HMS3715D21 
Pharmakon1600-01502348 
BCP12257 
HY-B0357 
Tox21_112645 
BBL005225 
BDBM50088493 
R-64433 
GP6995 
NSC759642 
STL135982 
AKOS005746928 
CCG-213044 
CS-2411 
KS-5064 
MCULE-4598187571 
NSC-759642 
SB18820 
DICLAZURIL 
NCGC00168785-02 
AC-12108 
AN-34253 
BC204051 
CC-26555 
SC-13717 
AB0105674 
AB2000434 
CAS-101831-37-2 
D5457 
101831-37-2 
FT-0603078 
SW199606-2 
D03794 
Diclazuril, VETRANAL(TM), analytical standard 
AB01562968_01 
AB01562968_02 
831D372 
A800467 
C-21857 
P 64433 
Clinacox 
I01-0373 
J-000501 
SR-05000001484-1 
SR-05000001484-2 
Diclazuril, United States Pharmacopeia (USP) Reference Standard 
2-[4-(4-chloro-alpha-cyanobenzyl)-3,5-dichlorophenyl]-1,2,4-triazine-3,5(2H,4H)-dione 
Diclazuril for system suitability, European Pharmacopoeia (EP) Reference Standard 
2,6-Dichloro-.alpha.-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)benzeneacetonitrile 
2,6-Dichloro-|A-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile 
2,6-Dichloro-|A-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl]benzeneacetonitrile 
Vecoxan 
2,6-dichloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile 
2,6-dichloro-alpha-(4-chlorophenyl)-4-[4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl]benzeneacetonitr 
2-[4-[3,5-bis(oxidanylidene)-1,2,4-triazin-2-yl]-2,6-bis(chloranyl)phenyl]-2-(4-chlorophenyl)ethanenitrile 
null 
Coxiril 
DCZL 
Diclazurilum [Latin] 
Diclazurilo [Spanish] 
UNII-K110K1B1VE 
C17H9Cl3N4O2 
2-(4-chlorophenyl)-2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]acetonitrile 
Diclazuril [USAN:BAN:INN] 
Diclazuril [USAN:INN:BAN] 
K110K1B1VE 
DRG-0079 
C17-H9-Cl3-N4-O2 
CID456389 
DL-164 
s2028 
CS-O-01281 
Diclazuril, 98% - 100MG 100mg 
Literature

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Journal: Parasitology research 20121001

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Title: Effects of kefir on coccidial oocysts excretion and performance of dairy goat kids following weaning.

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Title: Control strategies using diclazuril against coccidiosis in goat kids.

Journal: Parasitology research 20120601

Title: Adjuvant effect of ginsenoside-based nanoparticles (ginsomes) on the recombinant vaccine against Eimeria tenella in chickens.

Journal: Parasitology research 20120601

Title: Effect of the diclazuril on Hsp90 in the second-generation merozoites of Eimeria tenella.

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Title: Effect of isosporiasis prevention with toltrazuril on long-term pig performance.

Journal: TheScientificWorldJournal 20120101

Title: Development and validation of an UPLC-MS/MS method for the determination of ionophoric and synthetic coccidiostats in vegetables.

Journal: Analytical and bioanalytical chemistry 20111201

Title: Long-term effect of toltrazuril on growth performances of dairy heifers and beef calves exposed to natural Eimeria zuernii and Eimeria bovis infections.

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Title: Determination of eleven coccidiostats in animal feed by liquid chromatography-tandem mass spectrometry at cross contamination levels.

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Title: Development and validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for eleven coccidiostats in eggs.

Journal: Analytica chimica acta 20110826

Title: Determination of diclazuril, toltrazuril and its two metabolites in poultry tissues and eggs by gel permeation chromatography-liquid chromatography-tandem mass spectrometry.

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Title: Dose-response effects of diclazuril against pathogenic species of ovine coccidia and the development of protective immunity.

Journal: Veterinary parasitology 20110531

Title: The efficacy of anticoccidial products against Eimeria spp. in northern bobwhites.

Journal: Avian diseases 20110301

Title: [Determination of avermectin, diclazuril, toltrazuril and metabolite residues in pork by high performance liquid chromatography-tandem mass spectrometry].

Journal: Se pu = Chinese journal of chromatography 20110301

Title: Identification of clinically used drugs that activate pregnane X receptors.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20110101

Title: Differential gene expression in Schistosoma japonicum schistosomula from Wistar rats and BALB/c mice.

Journal: Parasites & vectors 20110101

Title: Calf health from birth to weaning. II. Management of diarrhoea in pre-weaned calves.

Journal: Irish veterinary journal 20110101

Title: Pharmacokinetic and tissue distribution of doxycycline in broiler chickens pretreated with either: diclazuril or halofuginone.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20101101

Title: Eimeria tenella: effects of diclazuril treatment on microneme genes expression in second-generation merozoites and pathological changes of caeca in parasitized chickens.

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Title: Multi-residue method for detecting coccidiostats at carry-over level in feed by HPLC-MS/MS.

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Title: Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry.

Journal: Journal of chromatography. A 20091113

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Title: Study of the comparative efficacy of toltrazuril and diclazuril against ovine coccidiosis in housed lambs.

Journal: Parasitology research 20090801

Title: Genotype comparison of sorbitol-negative Escherichia coli isolates from healthy broiler chickens from different commercial farms.

Journal: Poultry science 20090701

Title: Fast liquid chromatography/multiple-stage mass spectrometry of coccidiostats.

Journal: Rapid communications in mass spectrometry : RCM 20090501

Title: [Comparison of pretreatment methods for the simultaneous determination of diclazuril and toltrazuril residues in chicken tissues].

Journal: Se pu = Chinese journal of chromatography 20090501

Title: Efficacy of toltrazuril (Baycox 5% suspension) in natural infections with pathogenic Eimeria spp. in housed lambs.

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Title: The effect of a metaphylactic treatment with diclazuril (Vecoxan) on the oocyst excretion and growth performance of calves exposed to a natural Eimeria infection.

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Title: Use of antigen mimics to produce specific antibodies to anti-coccidial drugs.

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Title: Efficacy of various anticoccidials against experimental porcine neonatal isosporosis.

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Title: Increased level of Eimeria sensitivity to diclazuril after using a live coccidial vaccine.

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Title: Higher incidence of Eimeria spp. field isolates sensitive for diclazuril and monensin associated with the use of live coccidiosis vaccination with paracox-5 in broiler farms.

Journal: Avian diseases 20060901

Title: New therapeutic approaches for equine protozoal myeloencephalitis: pharmacokinetics of diclazuril sodium salts in horses.

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Title: Liquid chromatographic tandem mass spectrometric determination of five coccidiostats in poultry eggs and feed.

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Title: Detection of residues of the coccidiostat diclazuril in poultry tissues by liquid chromatography-tandem mass spectrometry after withdrawal of medicated feed.

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Title: Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry.

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Title: Control of coccidiosis in turkeys with diclazuril and monensin: effects upon performance and development of immunity to Eimeria species.

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Title: Effects of a herbal complex against Eimeria tenella infection in chickens.

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Title: Resistance to anticoccidial drugs of Dutch avian Eimeria spp. field isolates originating from 1996, 1999 and 2001.

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Title: Studies on the efficacy of toltrazuril, diclazuril and sulphadimidine against artificial infections with Isospora suis in piglets.

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Title: The use of diclazuril in extended withdrawal anticoccidial programs: 1. Efficacy against Eimeria spp. in broiler chickens in floor pens.

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Title: Quantitative analysis of diclazuril in animal plasma by liquid chromatography/electrospray ionization mass spectrometry.

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Title: Efficacy of diclazuril in comparison with chemical and ionophorous anticoccidials against Eimeria spp. in broiler chickens in floor pens.

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Title: In vitro quantitative analysis of (3)H-uracil incorporation by Sarcocytis neurona to determine efficacy of anti-protozoal agents.

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Title: Diclazuril preventive therapy of gamma interferon knockout mice fed Sarcocystis neurona sporocysts.

Journal: Veterinary parasitology 20010120

Title: Activity of diclazuril against Toxoplasma gondii in cultured cells and mice.

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Title: Assessment of candidate anticryptosporidial agents in an immunosuppressed rat model.

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Title: Anti-cryptosporidial drug activity screened with an immunosuppressed rat model.

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