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Title: Thymidylate synthase mRNA levels in plasma and tumor as potential predictive biomarkers for raltitrexed sensitivity in gastric cancer.
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Title: Novel tricyclic indeno[2,1-d]pyrimidines with dual antiangiogenic and cytotoxic activities as potent antitumor agents.
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Title: Influence of resistance to 5-fluorouracil and tomudex on [18F]‑FDG incorporation, glucose transport and hexokinase activity.
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Title: Preclinical studies identify novel targeted pharmacological strategies for treatment of human malignant pleural mesothelioma.
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Title: Systemic treatment of malignant pleural mesothelioma.
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Title: Raltitrexed plus cisplatin is cost-effective compared with pemetrexed plus cisplatin in patients with malignant pleural mesothelioma.
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Title: Substrate- and pH-specific antifolate transport mediated by organic anion-transporting polypeptide 2B1 (OATP2B1-SLCO2B1).
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Title: Folic acid supplementation increases survival and modulates high risk HPV-induced phenotypes in oral squamous cell carcinoma cells and correlates with p53 mRNA transcriptional down-regulation.
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Title: Constitutive and treatment-induced CXCL8-signalling selectively modulates the efficacy of anti-metabolite therapeutics in metastatic prostate cancer.
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Title: Long-term outcome of patients with complete pathologic response after neoadjuvant chemoradiation for cT3 rectal cancer: implications for local excision surgical strategies.
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Title: Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution.
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Title: Inhibitor-bound complexes of dihydrofolate reductase-thymidylate synthase from Babesia bovis.
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Title: SEOM guidelines for the treatment of malignant pleural mesothelioma.
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Title: PEA3/ETV4-related transcription factors coupled with active ERK signalling are associated with poor prognosis in gastric adenocarcinoma.
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Title: Tumor response is predicted by patient genetic profile in rectal cancer patients treated with neo-adjuvant chemo-radiotherapy.
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Title: Thymidylate synthase as a determinant of pemetrexed sensitivity in non-small cell lung cancer.
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Title: MicroRNA dysregulation in colorectal cancer: a clinical perspective.
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Title: Oxaliplatin plus dual inhibition of thymidilate synthase during preoperative pelvic radiotherapy for locally advanced rectal carcinoma: long-term outcome.
Journal: International journal of radiation oncology, biology, physics20110301
Title: Value of ADC measurements for nodal staging after chemoradiation in locally advanced rectal cancer-a per lesion validation study.
Journal: European radiology20110201
Title: Adjuvant chemotherapy for localised colon cancer. Fluorouracil + folinic acid for node-positive, non-metastatic disease.
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Title: Single agent and combination studies of pralatrexate and molecular correlates of sensitivity.
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Title: Human thymidylate synthase with loop 181-197 stabilized in an inactive conformation: ligand interactions, phosphorylation, and inhibition profiles.
Journal: Protein science : a publication of the Protein Society20110101
Title: Assessing methods for dealing with treatment switching in randomised controlled trials: a simulation study.
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Title: GTI: a novel algorithm for identifying outlier gene expression profiles from integrated microarray datasets.
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Title: Heath-related quality of life in thyroid cancer patients following radioiodine ablation.
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Title: An unusual presentation of multiple cavitated lung metastases from colon carcinoma.
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Title: Expression of RFC/SLC19A1 is associated with tumor type in bladder cancer patients.
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Title: A 26-year-old male with mesothelioma due to asbestos exposure.
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Title: Critical appraisal of pralatrexate in the management of difficult-to-treat peripheral T cell lymphoma.
Journal: Therapeutics and clinical risk management20110101
Title: Clinical characteristics and treatment outcomes in 132 patients with malignant mesothelioma.
Journal: Lung India : official organ of Indian Chest Society20110101
Title: The state of research into children with cancer across Europe: new policies for a new decade.
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Title: Investigational approaches for mesothelioma.
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Title: Phenotypic enhancement of thymidylate synthetase pathway inhibitors following ablation of Neil1 DNA glycosylase/lyase.
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Title: Antifolate inhibitors of thymidylate synthase as anticancer drugs.
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Title: Combination 5-fluorouracil, folinic acid and cisplatin (LV5FU2-CDDP) followed by gemcitabine or the reverse sequence in metastatic pancreatic cancer: final results of a randomised strategic phase III trial (FFCD 0301).
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Title: Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
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Title: Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking.
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Title: Identification of thymidylate synthase as a potential therapeutic target for lung cancer.
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Title: Understanding chemotherapy treatment pathways of advanced colorectal cancer patients to inform an economic evaluation in the United Kingdom.
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Title: Raltitrexed and oxaliplatin hepatic arterial infusion for advanced colorectal cancer: a retrospective study.
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Title: Characterisation of the bifunctional dihydrofolate synthase-folylpolyglutamate synthase from Plasmodium falciparum; a potential novel target for antimalarial antifolate inhibition.
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Title: Pyridinium 5-nitro-thio-phene-2-carboxyl-ate.
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Title: The role of folate receptor alpha (FRalpha) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy.
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Title: Defining patient outcomes in stage IV colorectal cancer: a prospective study with baseline stratification according to disease resectability status.
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Title: Colorectal cancer: response to sunitinib in a heavily pretreated colorectal cancer patient.
Journal: Anti-cancer drugs20100101
Title: Synthesis and biological activity of raltitrexed-carrier conjugates.
Journal: Acta biochimica Polonica20100101
Title: Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cells.
Journal: Molecular cancer20100101
Title: Interaction between thymidylate synthase and its cognate mRNA in zebrafish embryos.
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Title: Analysis of the thymidylate synthase gene structure in colorectal cancer patients and its possible relation with the 5-Fluorouracil drug response.
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Title: Molecular docking studies on quinazoline antifolate derivatives as human thymidylate synthase inhibitors.
Journal: Bioinformation20100101
Title: The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma.
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Title: CoFactor: Folate Requirement for Optimization of 5-Fluouracil Activity in Anticancer Chemotherapy.
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Title: Cancer chemotherapy: targeting folic acid synthesis.
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Title: Raltitrexed: optimism and reality.
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Title: Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
Journal: Cancer chemotherapy and pharmacology20091001
Title: Malignant pleural mesothelioma: an update on biomarkers and treatment.
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Title: Adjuvant chemotherapy for stages II, III and IV of colon cancer.
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Title: Cost-effectiveness analysis of XELOX for metastatic colorectal cancer based on the NO16966 and NO16967 trials.
Journal: British journal of cancer20090707
Title: C677T and A1298C MTHFR polymorphisms, a challenge for antifolate and fluoropyrimidine-based therapy personalisation.
Journal: European journal of cancer (Oxford, England : 1990)20090501
Title: Modulation of thymidilate synthase and p53 expression by HDAC inhibitor vorinostat resulted in synergistic antitumor effect in combination with 5FU or raltitrexed.
Journal: Cancer biology & therapy20090501
Title: Future developments in the management of malignant pleural mesothelioma.
Journal: Expert review of anticancer therapy20090401
Title: Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma.
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Title: Chiral separation of raltitrexed by cyclodextrin-modified micellar electrokinetic chromatography.
Journal: Analytical and bioanalytical chemistry20090101
Title: Late cutaneous metastases to the face from malignant pleural mesothelioma: a case report and review of the literature.
Journal: World journal of surgical oncology20090101
Title: Acute coronary syndrome associated with continuous 5-Fluorouracil infusion in a patient with metastatic colorectal cancer-a case report with a discussion on this clinical dilemma.
Journal: Journal of gastrointestinal cancer20090101
Title: An open label randomized multicentre phase IIIb trial comparing parenteral substitution versus best supportive nutritional care in subjects with pancreatic adenocarcinoma receiving 5-FU plus oxaliplatin as 2nd or higher line chemotherapy regarding clinical benefit - PANUSCO.
Journal: BMC cancer20090101
Title: APRIL is a novel clinical chemo-resistance biomarker in colorectal adenocarcinoma identified by gene expression profiling.
Journal: BMC cancer20090101
Title: Quality of life data as prognostic indicators of survival in cancer patients: an overview of the literature from 1982 to 2008.
Journal: Health and quality of life outcomes20090101
Title: Outcome for esophageal cancer following treatment with chemotherapy and radiotherapy but not esophagectomy: Nonsurgical treatment of esophageal cancer.
Journal: Clinical and experimental gastroenterology20090101
Title: Dynamics of antifolate transport via the reduced folate carrier and the membrane folate receptor in murine leukaemia cells in vitro and in vivo.
Journal: Cancer chemotherapy and pharmacology20081101
Title: DNA damage and homologous recombination signaling induced by thymidylate deprivation.
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Title: Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase.
Journal: DNA repair20081001
Title: Raltitrexed (Tomudex) versus standard leucovorin-modulated bolus 5-fluorouracil: Results from the randomised phase III Pan-European Trial in Adjuvant Colon Cancer 01 (PETACC-1).
Journal: European journal of cancer (Oxford, England : 1990)20081001
Title: The confused cancer patient: a case of 5-fluorouracil-induced encephalopathy.
Journal: Current oncology (Toronto, Ont.)20081001
Title: The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier.
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Title: Inequity in colorectal cancer treatment and outcomes: a population-based study.
Journal: British journal of cancer20080722
Title: EGFR-targeting drugs in combination with cytotoxic agents: from bench to bedside, a contrasted reality.
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Title: Pemetrexed plus carboplatin in elderly patients with malignant pleural mesothelioma: combined analysis of two phase II trials.
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Title: Cisplatin and vinorelbine first-line chemotherapy in non-resectable malignant pleural mesothelioma.
Journal: British journal of cancer20080708
Title: Chemical and genetic validation of dihydrofolate reductase-thymidylate synthase as a drug target in African trypanosomes.
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Title: A case of relapsing secondary bladder adenocarcinoma after right colonic cancer.
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Title: Systemic treatments for mesothelioma: standard and novel.
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Title: Switching to letrozole or exemestane improves hot flushes, mood and quality of life in tamoxifen intolerant women.
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Title: Low expression of gamma-glutamyl hydrolase mRNA in primary colorectal cancer with the CpG island methylator phenotype.
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Title: The use of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer: systematic review and economic evaluation.
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Title: Active symptom control with or without chemotherapy in the treatment of patients with malignant pleural mesothelioma (MS01): a multicentre randomised trial.
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Title: Irinotecan+5-fluorouracil with concomitant pre-operative radiotherapy in locally advanced non-resectable rectal cancer: a phase I/II study.
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Title: Current concepts in chemotherapy for malignant pleural mesothelioma.
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Title: Perioperative chemotherapy with FOLFOX4 and surgery versus surgery alone for resectable liver metastases from colorectal cancer (EORTC Intergroup trial 40983): a randomised controlled trial.
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Title: Randomized, multicenter, phase IIb study of preoperative chemoradiotherapy in T3 mid-distal rectal cancer: raltitrexed + oxaliplatin + radiotherapy versus cisplatin + 5-fluorouracil + radiotherapy.
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Title: Uracil incorporation into genomic DNA does not predict toxicity caused by chemotherapeutic inhibition of thymidylate synthase.
Journal: DNA repair20080201
Title: Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: Part II.
Journal: Anti-cancer agents in medicinal chemistry20080201
Title: Review of pemetrexed in combination with cisplatin for the treatment of malignant pleural mesothelioma.
Journal: Therapeutics and clinical risk management20080201
Title: Clinical study of combined use of tomudex (raltitrexed) and xeloda (capecitabine) as first-line treatment for patients with metastasizing colorectal cancer.
Journal: Bulletin of experimental biology and medicine20080201
Title: Chronic myeloid leukemia following the treatment of rectal adenocarcinoma.
Journal: Medical oncology (Northwood, London, England)20080101
Title: Kinetics and ligand-binding preferences of Mycobacterium tuberculosis thymidylate synthases, ThyA and ThyX.
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Title: Molecular analysis of the effects of Piroxicam and Cisplatin on mesothelioma cells growth and viability.
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Title: What oncologists tell patients about survival benefits of palliative chemotherapy and implications for informed consent: qualitative study.
Journal: BMJ (Clinical research ed.)20080101
Title: Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease.
Journal: BMC neuroscience20080101
Title: Intranasal administration of acetylcholinesterase inhibitors.
Journal: BMC neuroscience20080101
Title: Gemcitabine combined with oxaliplatin in pretreated patients with malignant pleural mesothelioma: an observational study.
Journal: Journal of occupational medicine and toxicology (London, England)20080101
Title: Malignant mesothelioma.
Journal: Orphanet journal of rare diseases20080101
Title: Successful and well-tolerated second line therapy with cetuximab, irinotecan, and raltitrexed in progressive liver disease due to metastatic colon cancer.
Journal: Journal of gastrointestinal cancer20080101
Title: A retrospective comparison of concurrent bolus 5-fluorouracil or raltitrexed in preoperative chemoradiation for locally advanced rectal cancer.
Journal: Hematology/oncology and stem cell therapy20080101
Title: Symptoms and patient-reported well-being: do they predict survival in malignant pleural mesothelioma? A prognostic factor analysis of EORTC-NCIC 08983: randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma.
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Title: In Australia, patients and government at odds over mesothelioma treatment costs.
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Title: Adjuvant therapy with raltitrexed in patients with colorectal cancer intolerant of 5-fluorouracil: British Columbia Cancer Agency experience.
Journal: Cancer investigation20071201
Title: Progression-free survival is a surrogate for survival in advanced colorectal cancer.
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Title: Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules.
Journal: British journal of cancer20071022
Title: [18F]2-fluoro-2-deoxy-D-glucose incorporation by AGS gastric adenocarcinoma cells in vitro during response to epirubicin, cisplatin and 5-fluorouracil.
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Title: Preoperative chemoradiotherapy with capecitabine and oxaliplatin in locally advanced rectal cancer. A phase I-II multicenter study of the Dutch Colorectal Cancer Group.
Journal: Annals of surgical oncology20071001
Title: Recent advances in classical and non-classical antifolates as antitumor and antiopportunistic infection agents: part I.
Journal: Anti-cancer agents in medicinal chemistry20070901
Title: Human mass balance study of the novel anticancer agent ixabepilone using accelerator mass spectrometry.
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Title: Synergistic antitumour effect of raltitrexed and 5-fluorouracil plus folinic acid combination in human cancer cells.
Journal: Anti-cancer drugs20070801
Title: Therapy of colon carcinoma: an oncology perspective. Interview with Piotr M. Czaykowski by Paul C. Adams.
Journal: Canadian journal of gastroenterology = Journal canadien de gastroenterologie20070801
Title: Combination silencer RNA (siRNA) targeting Bcl-2 antagonizes siRNA against thymidylate synthase in human tumor cell lines.
Journal: The Journal of pharmacology and experimental therapeutics20070701
Title: Mechanisms of action of FdUMP[10]: metabolite activation and thymidylate synthase inhibition.
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Title: Determination of raltitrexed in human plasma by high performance liquid chromatography-electrospray ionization-mass spectrometry.
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Title: A systematic review of economic analyses of pharmaceutical therapies for advanced colorectal cancer.
Journal: Expert opinion on pharmacotherapy20070601
Title: A preclinical evaluation of pemetrexed and irinotecan combination as second-line chemotherapy in pancreatic cancer.
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Title: Mechanisms of acquired chemoresistance to 5-fluorouracil and tomudex: thymidylate synthase dependent and independent networks.
Journal: Cancer chemotherapy and pharmacology20070501
Title: Chemotherapy in advanced biliary tract carcinoma: a pooled analysis of clinical trials.
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Title: Failure to complete adjuvant chemotherapy is associated with adverse survival in stage III colon cancer patients.
Journal: British journal of cancer20070312
Title: Changes in the status of p53 affect drug sensitivity to thymidylate synthase (TS) inhibitors by altering TS levels.
Journal: British journal of cancer20070312
Title: An evaluation of thymidine phosphorylase as a means of preventing thymidine rescue from the thymidylate synthase inhibitor raltitrexed.
Journal: Cancer chemotherapy and pharmacology20070201
Title: Polymorphisms in the thymidylate synthase and dihydropyrimidine dehydrogenase genes predict response and toxicity to capecitabine-raltitrexed in colorectal cancer.
Journal: Oncology reports20070201
Title: Cost-effectiveness analysis of cetuximab/irinotecan vs active/best supportive care for the treatment of metastatic colorectal cancer patients who have failed previous chemotherapy treatment.
Journal: British journal of cancer20070129
Title: Antisense targeting of thymidylate synthase (TS) mRNA increases TS gene transcription and TS protein: effects on human tumor cell sensitivity to TS enzyme-inhibiting drugs.
Journal: Gene expression20070101
Title: Cost considerations in the treatment of colorectal cancer.
Journal: PharmacoEconomics20070101
Title: Surgical outcomes for colon and rectal cancer over a decade: results from a consecutive monocentric experience in 902 unselected patients.
Journal: World journal of surgical oncology20070101
Title: Human agonistic TRAIL receptor antibodies Mapatumumab and Lexatumumab induce apoptosis in malignant mesothelioma and act synergistically with cisplatin.
Journal: Molecular cancer20070101
Title: Effects of antifolate drugs on the cellular uptake of radiofolates in vitro and in vivo.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20061201
Title: Cost-effectiveness of oxaliplatin and capecitabine in the adjuvant treatment of stage III colon cancer.
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Title: Biology and management of malignant pleural mesothelioma.
Journal: European journal of cancer (Oxford, England : 1990)20061101
Title: St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis.
Journal: Toxicology and applied pharmacology20061015
Title: Identification of gene polymorphisms of human DNA topoisomerase I in the National Cancer Institute panel of human tumour cell lines.
Journal: British journal of cancer20061009
Title: Raltitrexed and pemetrexed studies in mesothelioma have not shown improved quality of life nor prolonged survival compared with effective pleurodesis with thoracoscopic talc poudrage.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20061001
Title: A phase I study of pemetrexed (LY231514) supplemented with folate and vitamin B12 in Japanese patients with solid tumours.
Journal: British journal of cancer20060918
Title: A multicenter phase III trial comparing irinotecan-gemcitabine (IG) with gemcitabine (G) monotherapy as first-line treatment in patients with locally advanced or metastatic pancreatic cancer.
Journal: British journal of cancer20060904
Title: ['Iatrogenic acute coronary syndrome'--59 year old patient with adenocarcinoma of ascending colon and stenocardia while receiving adjuvant chemotherapy with 5-fluorouracil].
Journal: Zeitschrift fur Gastroenterologie20060901
Title: Systemic chemotherapy in the management of malignant peritoneal mesothelioma.
Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology20060801
Title: First-line 5-fluorouracil/folinic acid, oxaliplatin and irinotecan (FOLFOXIRI) does not impair the feasibility and the activity of second line treatments in metastatic colorectal cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20060801
Title: A proposed clinical test for monitoring fluoropyrimidine therapy: detection and stability of thymidylate synthase ternary complexes.
Journal: Cancer biology & therapy20060801
Title: 18F-FDG PET is an early predictor of pathologic tumor response to preoperative radiochemotherapy in locally advanced rectal cancer.
Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20060801
Title: The combination of raltitrexed (Tomudex) and mitomycin-C in the treatment of advanced colorectal cancer--a phase II study.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain))20060801
Title: Severe enteropathy associated with raltitrexed and oxaliplatin chemotherapy: report of two patients experiencing this rare, potentially lethal gastrointestinal adverse event.
Journal: Anti-cancer drugs20060801
Title: The clinical and economic benefits of capecitabine and tegafur with uracil in metastatic colorectal cancer.
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Title: The use of chemotherapy in patients with advanced malignant pleural mesothelioma: a systematic review and practice guideline.
Journal: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer20060701
Title: Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets.
Journal: Journal of theoretical biology20060621
Title: Biweekly oxaliplatin, raltitrexed, 5-fluorouracil and folinic acid combination chemotherapy during preoperative radiation therapy for locally advanced rectal cancer: a phase I-II study.
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Title: Raltitrexed plus levofolinic acid and bolus/continuous infusion 5-fluorouracil on a biweekly schedule for elderly patients with advanced colorectal carcinomas.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20060601
Title: Adding raltitrexed to cisplatin improves overall survival in people with malignant pleural mesothelioma.
Journal: Cancer treatment reviews20060501
Title: XELOX (capecitabine plus oxaliplatin) as first-line treatment for elderly patients over 70 years of age with advanced colorectal cancer.
Journal: British journal of cancer20060410
Title: Irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer.
Journal: Expert opinion on pharmacotherapy20060401
Title: Raltitrexed-eloxatin salvage chemotherapy in gemcitabine-resistant metastatic pancreatic cancer.
Journal: British journal of cancer20060327
Title: Short-term treatment-related symptoms and quality of life: results from an international randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an EORTC Lung-Cancer Group and National Cancer Institute, Canada, Intergroup Study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20060320
Title: Preoperative hyperfractionated chemoradiation for locally recurrent rectal cancer in patients previously irradiated to the pelvis: A multicentric phase II study.
Journal: International journal of radiation oncology, biology, physics20060315
Title: Quantitative structure-pharmacokinetic relationships for drug clearance by using statistical learning methods.
Journal: Journal of molecular graphics & modelling20060301
Title: Uridine diphosphate glucuronosyl transferase 1A1 promoter polymorphism predicts the risk of gastrointestinal toxicity and fatigue induced by irinotecan-based chemotherapy.
Journal: Cancer20060301
Title: Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase.
Journal: The Biochemical journal20060215
Title: The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line.
Journal: Molecular cancer therapeutics20060201
Title: Antimetabolites and cancer: emerging data with a focus on antifolates.
Journal: Expert opinion on therapeutic patents20060201
Title: Low folate conditions may enhance the interaction of trifluorothymidine with antifolates in colon cancer cells.
Journal: Cancer chemotherapy and pharmacology20060101
Title: Study on brain targeting of raltitrexed following intranasal administration in rats.
Journal: Cancer chemotherapy and pharmacology20060101
Title: A National Cancer Institute of Canada Clinical Trials Group Study--IND.135: Phase I/II study of irinotecan (camptosar), oxaliplatin and raltitrexed (tomudex) (COT) in patients with advanced colorectal cancer.
Journal: European journal of cancer (Oxford, England : 1990)20060101
Title: Raltitrexed plus oxaliplatin in the second-line treatment of metastatic colorectal cancer.
Journal: Neoplasma20060101
Title: Analysis of folylpoly-gamma-glutamate synthetase gene expression in human B-precursor ALL and T-lineage ALL cells.
Journal: BMC cancer20060101
Title: Randomised trial comparing three different schedules of infusional 5FU and raltitrexed alone as first-line therapy in metastatic colorectal cancer. Final results of the Fédération Francophone de Cancérologie Digestive (FFCD) 9601 trial.
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Title: Pre-operative radiochemotherapy with raltitrexed for resectable locally-advanced rectal cancer: a phase II study.
Journal: Anticancer research20060101
Title: The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.
Journal: Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy20060101
Title: Metachronic malignant transformation of small bowel and rectal endometriosis in the same patient.
Journal: World journal of surgical oncology20060101
Title: Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study.
Journal: Trials20060101
Title: Oxaliplatin with raltitrexed and preoperative radiotherapy in T3-T4 extraperitoneal rectal cancer. A dose finding study.
Journal: Tumori20060101
Title: [A review of chemotherapy for metastatic colon cancer].
Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria20060101
Title: Cost-effectiveness analysis of first-line chemotherapies in metastatic colorectal cancer. Results of the Fédération Francophone de Cancérologie Digestive (FFCD) 9601 randomized trial.
Journal: Oncology20060101
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Title: Pemetrexed: new drug. Pleural mesothelioma: a first encouraging trial.
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Title: Chemotherapy of metastatic colorectal cancer: fluorouracil plus folinic acid and irinotecan or oxaliplatin.
Journal: Prescrire international20051201
Title: Phase II randomised trial of raltitrexed-oxaliplatin vs raltitrexed-irinotecan as first-line treatment in advanced colorectal cancer.
Journal: British journal of cancer20051128
Title: Determination of apoptosis, uracil incorporation, DNA strand breaks, and sister chromatid exchanges under conditions of thymidylate deprivation in a model of BER deficiency.
Journal: Biochemical pharmacology20051115
Title: A phase I/II study of oxaliplatin when added to 5-fluorouracil and leucovorin and pelvic radiation in locally advanced rectal cancer: a Colorectal Clinical Oncology Group (CCOG) study.
Journal: British journal of cancer20051031
Title: A phase I pharmacokinetic and pharmacodynamic study of BGC9331 and carboplatin in relapsed gynaecological malignancies.
Journal: British journal of cancer20051017
Title: Randomized phase III study of cisplatin with or without raltitrexed in patients with malignant pleural mesothelioma: an intergroup study of the European Organisation for Research and Treatment of Cancer Lung Cancer Group and the National Cancer Institute of Canada.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20051001
Title: Effect of p53 status and STAT1 on chemotherapy-induced, Fas-mediated apoptosis in colorectal cancer.
Journal: Cancer research20051001
Title: ABCG2 harboring the Gly482 mutation confers high-level resistance to various hydrophilic antifolates.
Journal: Cancer research20050915
Title: Capecitabine and mitomycin C as third-line therapy for patients with metastatic colorectal cancer resistant to fluorouracil and irinotecan.
Journal: British journal of cancer20050905
Title: Analysis of prognostic factors and applicability of Kohne's prognostic groups in patients with metastatic colorectal cancer treated with first-line irinotecan or oxaliplatin-based chemotherapy.
Journal: Clinical colorectal cancer20050901
Title: Overview on ongoing or planned clinical trials in Europe.
Journal: Lung cancer (Amsterdam, Netherlands)20050701
Title: Enhancement of 5-fluorouracil sensitivity by an rTS signaling mimic in H630 colon cancer cells.
Journal: Cancer research20050701
Title: Raltitrexed-Oxaliplatin combination chemotherapy is inactive as second-line treatment for malignant pleural mesothelioma patients.
Journal: Lung cancer (Amsterdam, Netherlands)20050601
Title: A novel polypyrimidine antitumor agent FdUMP[10] induces thymineless death with topoisomerase I-DNA complexes.
Journal: Cancer research20050601
Title: The use of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer.
Journal: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology20050501
Title: [Development in the treatment of malignant mesothelioma].
Journal: Nederlands tijdschrift voor geneeskunde20050402
Title: Optimisation of irinotecan dose in the treatment of patients with metastatic colorectal cancer after 5-FU failure: results from a multinational, randomised phase II study.
Journal: British journal of cancer20050328
Title: Chemotherapy options and new advances in malignant pleural mesothelioma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20050301
Title: Phase I trial and pharmacokinetic study of raltitrexed in children with recurrent or refractory leukemia: a pediatric oncology group study.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20050301
Title: DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
Journal: The Journal of biological chemistry20050218
Title: A phase II study of raltitrexed and gemcitabine in patients with advanced pancreatic carcinoma.
Journal: British journal of cancer20050214
Title: Characterization of binding of folates and antifolates to brush-border membrane vesicles isolated from human kidney.
Journal: Molecular pharmacology20050201
Title: Phase I study of Tomudex and Doxorubicin in patients with locally advanced, inoperable or metastatic cancer (IND.98).
Journal: Investigational new drugs20050101
Title: ZD9331: discovery to clinical development.
Journal: Anti-cancer drugs20050101
Title: A study of the effect of temperature on the pharmacokinetic profile of raltitrexed administered by intraperitoneal route in the rat.
Journal: Medical science monitor : international medical journal of experimental and clinical research20050101
Title: Novel chemical strategies for thymidylate synthase inhibition.
Journal: Current medicinal chemistry20050101
Title: Synergistic antitumor activity of capecitabine in combination with irinotecan.
Journal: Clinical colorectal cancer20050101
Title: Importance of preclinical investigations of the integration of capecitabine into polychemotherapy regimens.
Journal: Clinical colorectal cancer20050101
Title: Phase I study of concomitant chemoradiation with raltitrexed in locally advanced head and neck cancer.
Journal: European journal of cancer (Oxford, England : 1990)20050101
Title: New drugs for colorectal cancer (irinotecan, oxaliplatin, raltitrexed) meet expectations in routine practice: a single center's experience before and after their introduction.
Journal: International journal of gastrointestinal cancer20050101
Title: First-line treatment with irinotecan and raltitrexed in metastatic colorectal cancer. Mature results of a multicenter phase II study.
Journal: Oncology20050101
Title: Phase II trial of irinotecan and raltitrexed in chemotherapy-naive advanced colorectal cancer.
Journal: Anticancer research20050101
Title: A phase II trial of raltitrexed (Tomudex) in advanced pancreatic and biliary carcinoma.
Journal: Oncology20050101
Title: Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer.
Journal: BMC cancer20050101
Title: Carboplatin in combination with raltitrexed in recurrent and metastatic head and neck squamous cell carcinoma: A multicentre phase II study of the Gruppo Oncologico Dell'Italia Meridionale (G.O.I.M.).
Journal: Anticancer research20050101
Title: Survival after oxaliplatin therapy of irinotecan-pretreated advanced colorectal cancer patients.
Journal: Hepato-gastroenterology20050101
Title: Raltitrexed and radiotherapy as adjuvant treatment for stage II-III rectal cancer: a feasibility study.
Journal: Tumori20050101
Title: Raltitrexed increases tumorigenesis as a single agent yet exhibits anti-tumor synergy with 5-fluorouracil in ApcMin/+ mice.
Journal: Cancer biology & therapy20041101
Title: Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy.
Journal: British journal of cancer20041018
Title: A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer.
Journal: British journal of cancer20041018
Title: Epirubicin, cisplatin, and raltitrexed in patients with advanced gastric and hepatobiliary carcinoma: a phase II study.
Journal: American journal of clinical oncology20041001
Title: Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040915
Title: A comprehensive in vitro characterization of pancreatic ductal carcinoma cell line biological behavior and its correlation with the structural and genetic profile.
Journal: Virchows Archiv : an international journal of pathology20040901
Title: Chemoradiation with raltitrexed (Tomudex) in preoperative treatment of stage II-III resectable rectal cancer: a phase II study.
Journal: International journal of radiation oncology, biology, physics20040901
Title: Chemoradiation with raltitrexed and oxaliplatin in preoperative treatment of stage II-III resectable rectal cancer: Phase I and II studies.
Journal: International journal of radiation oncology, biology, physics20040901
Title: Thymidylate synthase: a critical target in cancer therapy?
Journal: Frontiers in bioscience : a journal and virtual library20040901
Title: UGT1A1 gene variations and irinotecan treatment in patients with metastatic colorectal cancer.
Journal: British journal of cancer20040816
Title: Chemotherapy for malignant pleural mesothelioma: past results and recent developments.
Journal: Lung cancer (Amsterdam, Netherlands)20040801
Title: p14ARF expression increases dihydrofolate reductase degradation and paradoxically results in resistance to folate antagonists in cells with nonfunctional p53.
Journal: Cancer research20040615
Title: Involvement of base excision repair in response to therapy targeted at thymidylate synthase.
Journal: Molecular cancer therapeutics20040601
Title: Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly.
Journal: British journal of cancer20040517
Title: The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040515
Title: Selective preservation of pemetrexed pharmacological activity in HeLa cells lacking the reduced folate carrier: association with the presence of a secondary transport pathway.
Journal: Cancer research20040501
Title: Irinotecan plus raltitrexed as first-line treatment in advanced colorectal cancer: a phase II study.
Journal: British journal of cancer20040419
Title: Population pharmacokinetics of raltitrexed in patients with advanced solid tumours.
Journal: British journal of clinical pharmacology20040401
Title: A phase I and pharmacokinetic study of irinotecan given as a 7-day continuous infusion in metastatic colorectal cancer patients pretreated with 5-fluorouracil or raltitrexed.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040301
Title: Phase I trial of sequential raltitrexed followed by bolus 5-fluorouracil in patients with advanced colorectal cancer.
Journal: Anti-cancer drugs20040301
Title: Structural determinants for the intracellular degradation of human thymidylate synthase.
Journal: Biochemistry20040224
Title: Small interfering double-stranded RNAs as therapeutic molecules to restore chemosensitivity to thymidylate synthase inhibitor compounds.
Journal: Cancer research20040215
Title: The role of alpha-folate receptor-mediated transport in the antitumor activity of antifolate drugs.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20040201
Title: Effects of ligand binding and conformational switching on intracellular stability of human thymidylate synthase.
Journal: Biochimica et biophysica acta20040114
Title: Cancer pharmacogenetics.
Journal: British journal of cancer20040112
Title: Phase II study of viscum fraxini-2 in patients with advanced hepatocellular carcinoma.
Journal: British journal of cancer20040112
Title: Management of colorectal cancer in elderly patients: focus on the cost of chemotherapy.
Journal: Drugs & aging20040101
Title: Treatment of colorectal cancer metastasis: the role of chemotherapy.
Journal: Cancer metastasis reviews20040101
Title: Raltitrexed plus weekly oxaliplatin as first-line chemotherapy in metastatic colorectal cancer: a multicenter non-randomized phase ii study.
Journal: Medical oncology (Northwood, London, England)20040101
Title: 5-Fluorouracil: identification of novel downstream mediators of tumour response.
Journal: Anticancer research20040101
Title: Activity and toxicity of oxaliplatin plus raltitrexed in 5-fluorouracil refractory metastatic colorectal adeno-carcinoma.
Journal: Anticancer research20040101
Title: Raltitrexed plus oxaliplatin in the treatment of metastatic colorectal cancer.
Journal: Tumori20040101
Title: Efficacy of infusional biomodulated 5-fluorouracil in metastatic colorectal cancer after raltitrexed failure.
Journal: Anticancer research20040101
Title: Neoadjuvant therapy of rectal cancer new treatment perspectives.
Journal: Tumori20040101
Title: Raltitrexed plus gemcitabine (TOMGEM) in advanced pancreatic cancer. Results of a Belgian multicentre phase II study.
Journal: Oncology20040101
Title: Combination chemotherapy in advanced gastrointestinal cancers: ex vivo sensitivity to gemcitabine and mitomycin C.
Journal: British journal of cancer20031215
Title: Prospective randomised phase II study of gemcitabine at standard or fixed dose rate schedule in unresectable hepatocellular carcinoma.
Journal: British journal of cancer20031117
Title: Oxaliplatin- or irinotecan-based chemotherapy for metastatic colorectal cancer in the elderly.
Journal: British journal of cancer20031020
Title: Review article: colorectal cancer chemotherapy.
Journal: Alimentary pharmacology & therapeutics20031001
Title: A new nonlinear mixture response surface paradigm for the study of synergism: a three drug example.
Journal: Current drug metabolism20031001
Title: Irinotecan plus leucovorin-modulated 5-fluorouracil I.V. bolus every other week may be a suitable therapeutic option also for elderly patients with metastatic colorectal carcinoma.
Journal: British journal of cancer20030915
Title: Hypersensitivity reactions related to oxaliplatin (OHP).
Journal: British journal of cancer20030804
Title: Thymidine and hypoxanthine protection patterns of the folic acid-enhanced synergies for combinations of trimetrexate plus a polyglutamylatable inhibitor of purine or thymidylate synthesis against human ileocecal HCT-8 cells.
Journal: International journal of oncology20030801
Title: Intestinal permeability in colorectal cancer patients treated by raltitrexed or irinotecan.
Journal: Journal of clinical gastroenterology20030801
Title: Induction of resistance to the multitargeted antifolate Pemetrexed (ALIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression.
Journal: Biochemical pharmacology20030801
Title: Lessons learned from raltitrexed--quality assurance, patient education and intensive supportive drugs to optimise tolerability.
Journal: Clinical oncology (Royal College of Radiologists (Great Britain))20030801
Title: Raltitrexed-induced hepatotoxicity: multivariate analysis of predictive factors.
Journal: Anti-cancer drugs20030801
Title: Thymidylate synthase inhibitors as anticancer agents: from bench to bedside.
Journal: Cancer chemotherapy and pharmacology20030701
Title: Multicenter phase II trial evaluating a three-weekly schedule of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20030701
Title: Treatment of advanced gastric cancer: where we are in 2003.
Journal: Onkologie20030601
Title: Second-line treatment of advanced gastric cancer with oxaliplatin plus raltitrexed.
Journal: Onkologie20030601
Title: Analysis of the time course and prognostic factors determining toxicity due to infused fluorouracil.
Journal: British journal of cancer20030519
Title: [Malignant pleural mesothelioma].
Journal: Gan to kagaku ryoho. Cancer & chemotherapy20030501
Title: Irinotecan plus raltitrexed vs raltitrexed alone in patients with gemcitabine-pretreated advanced pancreatic adenocarcinoma.
Journal: British journal of cancer20030422
Title: Combination chemotherapy for advanced colorectal cancer.
Journal: British journal of cancer20030407
Title: Raltitrexed plus radiotherapy for the treatment of unresectable/recurrent rectal cancer: a phase I study.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20030401
Title: Activity of raltitrexed and gemcitabine in advanced pancreatic cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20030401
Title: A 'combination oligonucleotide' antisense strategy to downregulate thymidylate synthase and decrease tumor cell growth and drug resistance.
Journal: Cancer gene therapy20030401
Title: Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy.
Journal: British journal of cancer20030324
Title: EORTC Early Clinical Studies Group early phase II trial of S-1 in patients with advanced or metastatic colorectal cancer.
Journal: British journal of cancer20030310
Title: Novel antifolate drugs.
Journal: Current oncology reports20030301
Title: [Severe acute cytomegalovirus colitis after administration of irinotecan and raltitrexed chemotherapy].
Journal: Gastroenterologie clinique et biologique20030301
Title: Constitutive nuclear factor-kappa B mRNA, protein overexpression and enhanced DNA-binding activity in thymidylate synthase inhibitor-resistant tumour cells.
Journal: British journal of cancer20030224
Title: Comparison of intermittent and continuous palliative chemotherapy for advanced colorectal cancer: a multicentre randomised trial.
Journal: Lancet (London, England)20030208
Title: The activity of raltitrexed (Tomudex) in malignant pleural mesothelioma: an EORTC phase II study (08992).
Journal: European journal of cancer (Oxford, England : 1990)20030201
Title: Expression of uracil DNA glycosylase (UDG) does not affect cellular sensitivity to thymidylate synthase (TS) inhibition.
Journal: European journal of cancer (Oxford, England : 1990)20030201
Title: Thymidylate synthase expression in advanced colorectal cancer predicts for response to raltitrexed.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20030201
Title: [Economic assessment of adjuvant and palliative chemotherapy in colorectal cancer: a review].
Journal: Bulletin du cancer20030201
Title: [Chemotherapy for colorectal cancers].
Journal: Journal de chirurgie20030201
Title: Chemotherapy for malignant pleural mesothelioma: past results and recent developments.
Journal: British journal of cancer20030127
Title: Combination of raltitrexed and oxaliplatin is an active regimen in malignant mesothelioma: results of a phase II study.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20030115
Title: Detection of thymidylate synthase modulators by a novel screening assay.
Journal: Molecular pharmacology20030101
Title: Pharmacokinetics studies and toxicity profile of raltitrexed used by intraperitoneal route in normothermia in a pig model.
Journal: Medical science monitor : international medical journal of experimental and clinical research20030101
Title: Severe liver dysfunction after raltitrexed administration in an HCV-positive colorectal cancer patient.
Journal: Cancer investigation20030101
Title: Oxaliplatin plus raltitrexed in the treatment of patients with advanced colorectal cancer: a phase II study.
Journal: Anticancer research20030101
Title: Palliative treatment of patients with colorectal cancer.
Journal: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society20030101
Title: Irinotecan in metastatic colorectal cancer: dose intensification and combination with new agents, including biological response modifiers.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20030101
Title: [Experience in treating elderly patients with disseminated stomach and colon cancer].
Journal: Advances in gerontology = Uspekhi gerontologii20030101
Title: [Early evaluation using PET-FDG of the efficiency of neoadjuvant radiochemotherapy treatment in locally advanced neoplasia of the lower rectum].
Journal: Tumori20030101
Title: Favorable toxicity profile of raltitrexed in elderly patients treated for colorectal cancer: a case series.
Journal: Gerontology20030101
Title: Raltitrexed and mitomycin-C as third-line chemotherapy for colorectal cancer after combination regimens including 5-fluorouracil, irinotecan and oxaliplatin: a phase II study.
Journal: Anticancer research20030101
Title: Anticancer antifolates: current status and future directions.
Journal: Current pharmaceutical design20030101
Title: New developments in systemic chemotherapy in advanced colorectal cancer.
Journal: Scandinavian journal of gastroenterology. Supplement20030101
Title: Up-regulation in dihydropyrimidine dehydrogenase activity by raltitrexed causes antagonism in combination with 5-fluorouracil.
Journal: Anticancer research20030101
Title: The rational principles of neo-adjuvant therapy for rectal cancer.
Journal: Acta bio-medica : Atenei Parmensis20030101
Title: Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis.
Journal: Biochimica et biophysica acta20021223
Title: The raltitrexed-vinorelbine combination: a phase I pharmacokinetic and pharmacodynamic trial in advanced breast cancer.
Journal: Cancer chemotherapy and pharmacology20021201
Title: Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.
Journal: Leukemia20021201
Title: Emerging insights into the biology and therapy of malignant mesothelioma.
Journal: Seminars in oncology20021201
Title: Phase II study of irinotecan with bolus and high dose infusional 5-FU and folinic acid (modified de Gramont) for first or second line treatment of advanced or metastatic colorectal cancer.
Journal: British journal of cancer20021118
Title: [New therapeutic options for mesothelioma].
Journal: Revue de pneumologie clinique20021101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology20021101
Title: Phase I and pharmacokinetic study of irinotecan in combination with raltitrexed.
Journal: Cancer chemotherapy and pharmacology20021001
Title: Oxaliplatin: results in colorectal carcinoma.
Journal: Critical reviews in oncology/hematology20021001
Title: Raltitrexed treatment promotes systemic inflammatory reaction in patients with colorectal carcinoma.
Journal: British journal of cancer20020909
Title: Irinotecan and raltitrexed: an active combination in advanced colorectal cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20020901
Title: Ex vivo stimulation of renal transport of the cytostatic drugs methotrexate, cisplatin, topotecan (Hycamtin) and raltitrexed (Tomudex) by dexamethasone, T3 and EGF in intact human and rat kidney tissue and in human renal cell carcinoma.
Journal: Urological research20020901
Title: Effects of antifolates on the binding of 5-fluoro-2'-deoxyuridine monophosphate to thymidylate synthase.
Journal: Biochemical pharmacology20020815
Title: The means to an end of tumor cell resistance to chemotherapeutic drugs targeting thymidylate synthase: shoot the messenger.
Journal: Current drug targets20020801
Title: Raltitrexed plus oxaliplatin as first-line chemotherapy in metastatic colorectal carcinoma: a multicentric phase II trial.
Journal: Anti-cancer drugs20020801
Title: Second-Line Treatment of Advanced Colorectal Cancer with a Biweekly Oxaliplatin plus Irinotecan Combination Regimen.
Journal: Onkologie20020801
Title: Toxicity analysis of the 5-day bolus 5-fluorouracil/folinic acid regimen for the treatment of colorectal carcinoma from 2 randomized controlled trials: a concern about dose.
Journal: Clinical colorectal cancer20020801
Title: A rationale for the clinical development of the thymidylate synthase inhibitor ZD9331 in ovarian and other solid tumours.
Journal: Biochimica et biophysica acta20020718
Title: Baseline quality of life predicts survival in patients with advanced colorectal cancer.
Journal: European journal of cancer (Oxford, England : 1990)20020701
Title: Multicenter non-randomized phase II study of raltitrexed (Tomudex) and oxaliplatin in non-pretreated metastatic colorectal cancer patients.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20020701
Title: Oxaliplatin plus raltitrexed and leucovorin-modulated 5-fluorouracil i.v. bolus: a salvage regimen for colorectal cancer patients.
Journal: British journal of cancer20020617
Title: Why hasn't the National Institute been 'NICE' to patients with colorectal cancer? National Institute of Clinical Excellence.
Journal: British journal of cancer20020605
Title: Which endpoints should we use in evaluating the use of novel fluoropyrimidine regimens in colorectal cancer?
Journal: British journal of cancer20020605
Title: Costs and consequences of different chemotherapy regimens in metastatic colorectal cancer.
Journal: British journal of cancer20020605
Title: Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: an active and low toxicity regimen.
Journal: European journal of cancer (Oxford, England : 1990)20020601
Title: Advanced colorectal cancer treatment in Europe: what have we achieved?
Journal: Anti-cancer drugs20020601
Title: Ralitrexed (Tomudex) or Nordic-FLv regimen in metastatic colorectal cancer: a randomized phase II study focusing on quality of life, patients' preferences and health economics.
Journal: Journal of chemotherapy (Florence, Italy)20020601
Title: Comparison of survival, palliation, and quality of life with three chemotherapy regimens in metastatic colorectal cancer: a multicentre randomised trial.
Journal: Lancet (London, England)20020504
Title: Phase I dose-escalating study of raltitrexed ('Tomudex') and cisplatin in metastatic non-small cell lung cancer.
Journal: Lung cancer (Amsterdam, Netherlands)20020501
Title: Raltitrexed plus oxaliplatin (TOMOX) as first-line chemotherapy for metastatic colorectal cancer. A phase II study of the Italian Group for the Study of Gastrointestinal Tract Carcinomas (GISCAD).
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20020501
Title: Pemetrexed for diffuse malignant pleural mesothelioma.
Journal: Seminars in oncology20020401
Title: Raltitrexed: current clinical status and future directions.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20020401
Title: Sequence-dependent effects of ZD1839 ('Iressa') in combination with cytotoxic treatment in human head and neck cancer.
Journal: British journal of cancer20020304
Title: Combined chemotherapy trials require combined pharmacogenetic approaches.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20020301
Title: Efficacy, tolerability and management of raltitrexed (Tomudex) monotherapy in patients with advanced colorectal cancer. a review of phase II/III trials.
Journal: European journal of cancer (Oxford, England : 1990)20020301
Title: Update on pharmacogenetics in cancer chemotherapy.
Journal: European journal of cancer (Oxford, England : 1990)20020301
Title: The emerging role of antifolates in the treatment of malignant pleural mesothelioma.
Journal: Seminars in oncology20020201
Title: Clinical and immunological assessment of Mycobacterium vaccae (SRL172) with chemotherapy in patients with malignant mesothelioma.
Journal: British journal of cancer20020201
Title: Raltitrexed (tomudex) administration in patients failing multiple prior chemotherapy regimens in advanced colorectal cancer: a pilot study.
Journal: Investigational new drugs20020201
Title: Thymidylate synthase: a critical target for cancer chemotherapy.
Journal: Clinical colorectal cancer20020201
Title: [The new chemotherapy of colorectal cancers].
Journal: Presse medicale (Paris, France : 1983)20020126
Title: Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Journal: Biochemical pharmacology20020115
Title: Randomized multicenter phase II trial of oxaliplatin plus irinotecan versus raltitrexed as first-line treatment in advanced colorectal cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20020101
Title: Patterns of elevation of plasma 2'-deoxyuridine, a surrogate marker of thymidylate synthase (TS) inhibition, after administration of two different schedules of 5-fluorouracil and the specific TS inhibitors raltitrexed (Tomudex) and ZD9331.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20020101
Title: Raltitrexed (Tomudex) administration in patients with relapsed metastatic colorectal cancer after weekly irinotecan/5-Fluorouracil/Leucovorin chemotherapy.
Journal: BMC cancer20020101
Title: Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Journal: Anti-cancer drugs20020101
Title: Multicenter phase I study of irinotecan plus raltitrexed in patients with 5-fluorouracil-refractory advanced colorectal cancer.
Journal: Oncology20020101
Title: Raltitrexed as monochemotherapy induces a statistically significant increase in platelet count.
Journal: Acta oncologica (Stockholm, Sweden)20020101
Title: Conjoint analysis of a new Chemotherapy: willingness to pay and preference for the features of raltitrexed versus standard therapy in advanced Colorectal Cancer.
Journal: PharmacoEconomics20020101
Title: [The rare manifestation of soft tissue metastasis in colorectal cancer].
Journal: Magyar onkologia20020101
Title: Cisplatin, raltitrexed, levofolinic acid and 5-fluorouracil in locally advanced or metastatic squamous cell carcinoma of the head and neck: a phase II randomized study.
Journal: Oncology20020101
Title: Chemotherapy in colorectal cancer: new options and new challenges.
Journal: British medical bulletin20020101
Title: [Raltitrexed and oxaliplatin in colorectal cancer: in vitro and in vivo study of a synergistic cytostatic combination].
Journal: Acta medica Austriaca20020101
Title: Raltitrexed (Tomudex): an alternative choice in patients intolerant to 5-fluorouracil.
Journal: Cancer investigation20020101
Title: Tolerability of Raltitrexed ('Tomudex') in elderly patients with colorectal cancer.
Journal: Anticancer research20020101
Title: A potential important role for thymidylate synthetase inhibition on antitumor activity of fluoropyrimidine and raltitexed.
Journal: Anticancer research20020101
Title: New cytotoxic agents and molecular-targeted therapies in the treatment of metastatic breast cancer.
Journal: Forum (Genoa, Italy)20020101
Title: Oxaliplatin: available data in non-colorectal gastrointestinal malignancies.
Journal: Critical reviews in oncology/hematology20011201
Title: Metastatic colorectal cancer.
Journal: Current treatment options in oncology20011201
Title: Preoperative chemoradiation with raltitrexed ('Tomudex') for T2/N+ and T3/N+ rectal cancers: a phase I study.
Journal: European journal of cancer (Oxford, England : 1990)20011101
Title: Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20011101
Title: Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20011101
Title: Thymidylate synthase pharmacogenetics in colorectal cancer.
Journal: Clinical colorectal cancer20011101
Title: Phase I clinical and pharmacogenetic trial of irinotecan and raltitrexed administered every 21 days to patients with cancer.
Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology20011015
Title: [New therapeutic options in chemotherapy of advanced colorectal cancer].
Journal: Medizinische Klinik (Munich, Germany : 1983)20011015
Title: A phase II study of epirubicin, cisplatin and raltitrexed combination chemotherapy (ECT) in patients with advanced oesophageal and gastric adenocarcinoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20011001
Title: [Recent aspects of palliative treatment of metastasized colorectal carcinoma].
Journal: Medizinische Klinik (Munich, Germany : 1983)20010915
Title: Multicenter phase II trial of dose-fractionated irinotecan in patients with advanced colorectal cancer failing oxaliplatin-based first-line combination chemotherapy.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010901
Title: Antifolate resistance and its circumvention by new analogues.
Journal: Human cell20010901
Title: Polymorphism in the thymidylate synthase promoter enhancer region in colorectal cancer.
Journal: International journal of oncology20010801
Title: [Oxaliplatin: a first DACH-platinum in oncology].
Journal: Bulletin du cancer20010801
Title: [Oxaliplatin in combination with non fluoropyrimidine drugs in colorectal cancer].
Journal: Bulletin du cancer20010801
Title: [New aspects in chemotherapy of tumors of the digestive tract].
Journal: Vnitrni lekarstvi20010801
Title: Pharmacogenomic dissection of resistance to thymidylate synthase inhibitors.
Journal: Cancer research20010715
Title: The impact of p53 status on cellular sensitivity to antifolate drugs.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20010701
Title: Raltitrexed/5-fluorouracil-based combination chemotherapy regimens in anticancer therapy.
Journal: Anti-cancer drugs20010701
Title: Integrating the oral fluoropyrimidines into the management of advanced colorectal cancer.
Journal: European journal of cancer (Oxford, England : 1990)20010501
Title: Crystal structure of a deletion mutant of human thymidylate synthase Delta (7-29) and its ternary complex with Tomudex and dUMP.
Journal: Protein science : a publication of the Protein Society20010501
Title: Modulation of both endogenous folates and thymidine enhance the therapeutic efficacy of thymidylate synthase inhibitors.
Journal: Cancer research20010501
Title: Combined effects of adenovirus-mediated wild-type p53 transduction, temozolomide and poly (ADP-ribose) polymerase inhibitor in mismatch repair deficient and non-proliferating tumor cells.
Journal: Cell death and differentiation20010501
Title: Phase I trial of sequential administration of raltitrexed (Tomudex) and 5-iodo-2'-deoxyuridine (IdUrd).
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010501
Title: Second-line treatment with oxaliplatin + raltitrexed in patients with advanced colorectal cancer failing fluoropyrimidine/leucovorin-based chemotherapy.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010501
Title: New therapies, new directions: advances in the systemic treatment of metastatic colorectal cancer.
Journal: The Lancet. Oncology20010501
Title: Advances in the treatment of metastatic colorectal cancer.
Journal: Clinical colorectal cancer20010501
Title: Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells.
Journal: Biochemical pharmacology20010401
Title: Oxaliplatin plus raltitrexed in patients with advanced colorectal carcinoma: results of a Phase I-II trial.
Journal: Cancer20010401
Title: The role of irinotecan and oxaliplatin in the treatment of advanced colorectal cancer.
Journal: Oncology (Williston Park, N.Y.)20010401
Title: Chemotherapy in elderly patients with colorectal cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010401
Title: Safe administration of irinotecan, oxaliplatin and raltitrexed in a DPD-deficient patient with metastatic colon cancer.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010401
Title: [New chemotherapies for colorectal cancer treatment].
Journal: Gastroenterologie clinique et biologique20010401
Title: A novel approach to thymidylate synthase as a target for cancer chemotherapy.
Journal: Molecular pharmacology20010301
Title: Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis.
Journal: Gastroenterology20010301
Title: A phase I study of a fixed dose of cisplatin with increasing doses of raltitrexed (Tomudex) in the treatment of patients with locally advanced or metastatic squamous cell carcinoma of the head and neck.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010301
Title: Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug.
Journal: Biochemistry20010220
Title: Use of the ratio of time to progression following first- and second-line therapy to document the activity of the combination of oxaliplatin with 5-fluorouracil in the treatment of colorectal carcinoma.
Journal: Annals of oncology : official journal of the European Society for Medical Oncology20010201
Title: [Non-alcoholic steatohepatitis with cirrhosis after raltitrexed administration].
Journal: Gastroenterologie clinique et biologique20010201
Title: Inhibition of thymidine synthesis by folate analogues induces a Fas-Fas ligand-independent deletion of superantigen-reactive peripheral T cells.
Journal: International immunology20010101
Title: The anticytomegaloviral activity of raltitrexed is abrogated in quiescent mouse fibroblasts that overexpress thymidylate synthase.
Journal: Virus research20010101
Title: Influence of cytokines, monoclonal antibodies and chemotherapeutic drugs on epithelial cell adhesion molecule (EpCAM) and LewisY antigen expression.
Journal: Clinical and experimental immunology20010101
Title: Schedule-dependent synergism and antagonism between raltitrexed ('Tomudex') and methotrexate in human colon cancer cell lines in vitro.
Journal: Japanese journal of cancer research : Gann20010101
Title: Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells.
Journal: Human gene therapy20010101
Title: Phase I study of mitoxantrone, raltitrexed, levofolinic acid and 5-fluorouracil in advanced solid tumours.
Journal: Cancer chemotherapy and pharmacology20010101
Title: [Raltitrexed in colorectal cancer].
Journal: Tumori20010101
Title: Management of chemotherapy-induced adverse effects in the treatment of colorectal cancer.
Journal: Drug safety20010101
Title: Molecular and cellular biology of the human reduced folate carrier.
Journal: Progress in nucleic acid research and molecular biology20010101
Title: A phase I study of raltitrexed (Tomudex) combined with carmofur in metastatic colorectal cancer.
Journal: Oncology20010101
Title: Characterization and drug sensitivity of four newly established colon adenocarcinoma cell lines to antifolate inhibitors of thymidylate synthase.
Journal: Oncology research20010101
Title: [Assessment of the cost of first line chemotherapy in metastatic colorectal cancer. Preliminary results in the FFCD 9601 trial].
Journal: Gastroenterologie clinique et biologique20010101
Title: [Irinotecan and tomudex in the treatment of patients with advanced cancer of the large intestine].
Journal: Voprosy onkologii20010101
Title: Present indications for adjuvant therapy in resectable rectal cancer.
Journal: Annali italiani di chirurgia20010101
Title: [Intraoperative radiotherapy (IORT) in the treatment of rectal cancer].
Journal: Annali italiani di chirurgia20010101
Title: Oxaliplatin and raltitrexed in the treatment of inoperable malignant pleural mesothelioma: results of a pilot study.
Journal: Tumori20010101
Title: A rapid and systematic review of the evidence for the clinical effectiveness and cost-effectiveness of irinotecan, oxaliplatin and raltitrexed for the treatment of advanced colorectal cancer.
Journal: Health technology assessment (Winchester, England)20010101
Title: [Oxaliplatin: combinations with thymidylate synthetase inhibitors: two consecutive phase II studies].
Journal: Tumori20010101
Title: [Colorectal cancer: irinotecan in combination with newer drugs].
Journal: Tumori20010101
Title: The thymidylate synthase inhibitor ZD1694 potently inhibits murine and human cytomegalovirus replication in quiescent fibroblasts.
Journal: Antiviral research20000801
Title: Antisense down-regulation of thymidylate synthase to suppress growth and enhance cytotoxicity of 5-FUdR, 5-FU and Tomudex in HeLa cells.
Journal: British journal of pharmacology19990801
Title: Syntheses and thymidylate synthase inhibitory activity of the poly-gamma-glutamyl conjugates of N-[5-[N-(3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino ]-2-thenoyl]-L-glutamic acid (ICI D1694) and other quinazoline antifolates.
Journal: Journal of medicinal chemistry19920306
Title: The renal effects of N10-propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue ICI D1694, in mice.
Journal: British journal of cancer19911101
Title: Zhao H, et al. Raltitrexed Inhibits HepG2 Cell Proliferation via G0/G1 Cell Cycle Arrest. Oncol Res. 2016;23(5):237-48
Title: Dong Y, et al. Raltitrexed's effect on the development of neural tube defects in mice is associated with DNA damage, apoptosis, and proliferation. Mol Cell Biochem. 2015 Jan;398(1-2):223-31.
Title: Xue S, et al. Raltitrexed induces mitochondrial-mediated apoptosis in SGC7901 human gastric cancer cells. Mol Med Rep. 2014 Oct;10(4):1927-34.
Title: Waldman BC, et al. Induction of intrachromosomal homologous recombination in human cells by raltitrexed, an inhibitor of thymidylate synthase. DNA Repair (Amst). 2008 Oct 1;7(10):1624-35.
