Name: Name:Fantofarone
Brand: AABLOCKS
SKU: AA008YVT
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA008YVT

Chemical Name: Fantofarone

CAS Number: 114432-13-2

Molecular Formula: C31H38N2O5S

Molecular Weight: 550.7088

MDL Number: MFCD00867144

SMILES: COc1cc(CCN(CCCOc2ccc(cc2)S(=O)(=O)c2c(cn3c2cccc3)C(C)C)C)ccc1OC

Properties

Complexity: 825

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 39

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 13

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 6.7

Literature fold

Title: (7R,8S,8aS)-8-Hydr-oxy-7-phenyl-perhydro-indolizin-3-one.

Journal: Acta crystallographica. Section E, Structure reports online20090601

Title: Potential roles of membrane fluidity and ceramide in hyperthermia and alcohol stimulation of TRAIL apoptosis.

Journal: Apoptosis : an international journal on programmed cell death20070901

Title: De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis.

Journal: Journal of leukocyte biology20070601

Title: Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma.

Journal: The FEBS journal20070601

Title: SR33805, a Ca2+ antagonist with length-dependent Ca2+ -sensitizing properties in cardiac myocytes.

Journal: British journal of pharmacology20030501

Title: Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells.

Journal: Experimental cell research20020215

Title: SR 33557, a novel calcium entry blocker. II. Interactions with 1,4-dihydropyridine, phenylalkylamine and benzothiazepine binding sites in rat heart sarcolemmal membranes.

Journal: The Journal of pharmacology and experimental therapeutics19901101

Title: Adovelande J, et al. Synergy between two calcium channel blockers, verapamil and fantofarone (SR33557), in reversing chloroquine resistance in Plasmodium falciparum. Biochem Pharmacol. 1998 Feb 15;55(4):433-40.

Title: Dongay B, et al. Effect of fantofarone, a new Ca2+ channel antagonist, on angioplasty-induced vasospasm in an atherosclerotic rabbit model. Biochem Pharmacol. 1998 Jun 15;55(12):2047-50.

114432-13-2 | Fantofarone