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1197160-78-3,MFCD16875679
Catalog No.:AA000PF6

1197160-78-3 | PKI-587

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $12.00
- +
5mg
98%
in stock  
$41.00   $29.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000PF6
Chemical Name:
PKI-587
CAS Number:
1197160-78-3
Molecular Formula:
C32H41N9O4
Molecular Weight:
615.7258
MDL Number:
MFCD16875679
SMILES:
O=C(Nc1ccc(cc1)c1nc(nc(n1)N1CCOCC1)N1CCOCC1)Nc1ccc(cc1)C(=O)N1CCC(CC1)N(C)C
Properties
Computed Properties
 
Complexity:
913  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.4  

Literature

Title: PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation.

Journal: The Journal of surgical research 20120801

Title: Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20110515

Title: PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.

Journal: Bioorganic & medicinal chemistry letters 20101001

Title: Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.

Journal: Journal of medicinal chemistry 20100325

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SDS
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1000339-83-2

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1344119-14-7

 1217103-26-8

1217103-26-8
Tags:1197160-78-3 Molecular Formula|1197160-78-3 MDL|1197160-78-3 SMILES|1197160-78-3 PKI-587
Catalog No.: AA000PF6
1197160-78-3,MFCD16875679
1197160-78-3 | PKI-587
Pack Size： 1mg
Purity： 98%
in stock
$16.00 $12.00
Pack Size： 5mg
Purity： 98%
in stock
$41.00 $29.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000PF6
Chemical Name: PKI-587
CAS Number: 1197160-78-3
Molecular Formula: C32H41N9O4
Molecular Weight: 615.7258
MDL Number: MFCD16875679
SMILES: O=C(Nc1ccc(cc1)c1nc(nc(n1)N1CCOCC1)N1CCOCC1)Nc1ccc(cc1)C(=O)N1CCC(CC1)N(C)C
Properties
Complexity: 913  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 45  
Hydrogen Bond Acceptor Count: 10  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.4  
Literature fold

Title: PKI-587 and sorafenib targeting PI3K/AKT/mTOR and Ras/Raf/MAPK pathways synergistically inhibit HCC cell proliferation.

Journal: The Journal of surgical research20120801

Title: Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors.

Journal: Bioorganic & medicinal chemistry letters20110815

Title: Antitumor efficacy of PKI-587, a highly potent dual PI3K/mTOR kinase inhibitor.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research20110515

Title: PKI-179: an orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor.

Journal: Bioorganic & medicinal chemistry letters20101001

Title: Bis(morpholino-1,3,5-triazine) derivatives: potent adenosine 5'-triphosphate competitive phosphatidylinositol-3-kinase/mammalian target of rapamycin inhibitors: discovery of compound 26 (PKI-587), a highly efficacious dual inhibitor.

Journal: Journal of medicinal chemistry20100325

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