120-21-8,MFCD00003382
Catalog No.:AA000PXC

120-21-8 | 4-(Diethylamino)benzaldehyde

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Purity
Availability
Price(USD)
Quantity
  
5g
98%
in stock  
$6.00   $4.00
- +
25g
95%
in stock  
$18.00   $13.00
- +
100g
95%
in stock  
$32.00   $23.00
- +
500g
98%
in stock  
$67.00   $47.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000PXC
Chemical Name:
4-(Diethylamino)benzaldehyde
CAS Number:
120-21-8
Molecular Formula:
C11H15NO
Molecular Weight:
177.2429
MDL Number:
MFCD00003382
SMILES:
CCN(c1ccc(cc1)C=O)CC
NSC Number:
8782
Properties
Properties
 
BP:
329.6°C at 760 mmHg  
Form:
Solid  
MP:
37-41 °C  
Refractive Index:
1.5302 (estimate)  
Solubility:
2.5g/l  
Stability:
Air Sensitive  
Storage:
Inert atmosphere;2-8℃;  

Computed Properties
 
Complexity:
146  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.5  

Literature

Title: N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

Journal: Chemico-biological interactions 20150605

Title: Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120715

Title: (E)-4-[4-(Diethyl-amino)-benzyl-idene-ammonio]-benzene-sulfonate.

Journal: Acta crystallographica. Section E, Structure reports online 20120701

Title: Retinoic acid signaling plays a restrictive role in zebrafish primitive myelopoiesis.

Journal: PloS one 20120101

Title: Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity.

Journal: Frontiers in molecular neuroscience 20120101

Title: Genomic characterization, phylogeny and gene regulation of g-type lysozyme in sole (Solea senegalensis).

Journal: Fish & shellfish immunology 20111201

Title: Synthesis, characterization, and spectroscopic investigation of benzoxazole conjugated Schiff bases.

Journal: The journal of physical chemistry. A 20111124

Title: 2-[4-(Diethyl-amino)-benzyl-idene]malono-nitrile.

Journal: Acta crystallographica. Section E, Structure reports online 20110601

Title: 2-[(E)-4-(Diethyl-amino)-styr-yl]-1-methyl-pyridinium iodide.

Journal: Acta crystallographica. Section E, Structure reports online 20101001

Title: 4-Bromo-N-[4-(diethyl-amino)-benzyl-idene]aniline.

Journal: Acta crystallographica. Section E, Structure reports online 20100901

Title: Cationic schiff base amphiphiles and their metal complexes: Surface and biocidal activities against bacteria and fungi.

Journal: Colloids and surfaces. B, Biointerfaces 20100501

Title: (E)-1-(4-Chloro-phen-yl)-3-[4-(diethyl-amino)phen-yl]prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: 4-Chloro-N-[4-(diethyl-amino)benzyl-idene]aniline.

Journal: Acta crystallographica. Section E, Structure reports online 20100201

Title: Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

Journal: Neural development 20100101

Title: 4-[4-(Diethyl-amino)benzyl-ideneamino]-4H-1,2,4-triazole.

Journal: Acta crystallographica. Section E, Structure reports online 20080601

Title: Reactivity of the triple ion and separated ion pair of tris(trimethylsilyl)methyllithium with aldehydes: a RINMR study.

Journal: Journal of the American Chemical Society 20080514

Title: Synthesis, acidity and antioxidant properties of some novel 3,4-disubstituted-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives.

Journal: Molecules (Basel, Switzerland) 20080119

Title: Identification of a novel retinoid by small molecule screening with zebrafish embryos.

Journal: PloS one 20080101

Title: Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy.

Journal: PloS one 20080101

Title: Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo.

Journal: PLoS biology 20071101

Title: The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros.

Journal: PLoS genetics 20071001

Title: 4-(N,N-diethylamino) benzaldehyde thiosemicarbazone in the spectrophotometric determination of palladium.

Journal: Annali di chimica 20071001

Title: Systemic bud induction and retinoic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.

Journal: PLoS biology 20070401

Title: Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish.

Journal: Developmental biology 20070315

Title: Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development.

Journal: Development (Cambridge, England) 20070101

Title: A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes.

Journal: Developmental biology 20060901

Title: A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.

Journal: Molecular endocrinology (Baltimore, Md.) 20060701

Title: Retinoic acid activates myogenesis in vivo through Fgf8 signalling.

Journal: Developmental biology 20060101

Title: Development and validation of an HPLC-UV method for the analysis of methoxyamine using 4-(diethylamino)benzaldehyde as a derivatizing agent.

Journal: Journal of pharmaceutical and biomedical analysis 20050915

Title: Retionic acid and its receptors are required for expression of aryl hydrocarbon receptor mRNA and embryonic development of blood vessel and bone in the medaka fish, Oryzias latipes.

Journal: Zoological science 20040501

Title: Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005

Title: 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.

Journal: BMC pharmacology 20020101

Title: Measurement of cytokine and adhesion molecule expression in synovial tissue by digital image analysis.

Journal: Annals of the rheumatic diseases 20010301

Title: De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.

Journal: The Journal of biological chemistry 19960517

Title: Luo M, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7.

Title: Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42.

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SDS
Tags:120-21-8 Molecular Formula|120-21-8 MDL|120-21-8 SMILES|120-21-8 4-(Diethylamino)benzaldehyde
Catalog No.: AA000PXC
120-21-8,MFCD00003382
120-21-8 | 4-(Diethylamino)benzaldehyde
Pack Size: 5g
Purity: 98%
in stock
$6.00 $4.00
Pack Size: 25g
Purity: 95%
in stock
$18.00 $13.00
Pack Size: 100g
Purity: 95%
in stock
$32.00 $23.00
Pack Size: 500g
Purity: 98%
in stock
$67.00 $47.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000PXC
Chemical Name: 4-(Diethylamino)benzaldehyde
CAS Number: 120-21-8
Molecular Formula: C11H15NO
Molecular Weight: 177.2429
MDL Number: MFCD00003382
SMILES: CCN(c1ccc(cc1)C=O)CC
NSC Number: 8782
Properties
BP: 329.6°C at 760 mmHg  
Form: Solid  
MP: 37-41 °C  
Refractive Index: 1.5302 (estimate)  
Solubility: 2.5g/l  
Stability: Air Sensitive  
Storage: Inert atmosphere;2-8℃;  
Complexity: 146  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.5  
Literature fold

Title: N,N-diethylaminobenzaldehyde (DEAB) as a substrate and mechanism-based inhibitor for human ALDH isoenzymes.

Journal: Chemico-biological interactions20150605

Title: Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20120715

Title: (E)-4-[4-(Diethyl-amino)-benzyl-idene-ammonio]-benzene-sulfonate.

Journal: Acta crystallographica. Section E, Structure reports online20120701

Title: Retinoic acid signaling plays a restrictive role in zebrafish primitive myelopoiesis.

Journal: PloS one20120101

Title: Conditional RARα knockout mice reveal acute requirement for retinoic acid and RARα in homeostatic plasticity.

Journal: Frontiers in molecular neuroscience20120101

Title: Genomic characterization, phylogeny and gene regulation of g-type lysozyme in sole (Solea senegalensis).

Journal: Fish & shellfish immunology20111201

Title: Synthesis, characterization, and spectroscopic investigation of benzoxazole conjugated Schiff bases.

Journal: The journal of physical chemistry. A20111124

Title: 2-[4-(Diethyl-amino)-benzyl-idene]malono-nitrile.

Journal: Acta crystallographica. Section E, Structure reports online20110601

Title: 2-[(E)-4-(Diethyl-amino)-styr-yl]-1-methyl-pyridinium iodide.

Journal: Acta crystallographica. Section E, Structure reports online20101001

Title: 4-Bromo-N-[4-(diethyl-amino)-benzyl-idene]aniline.

Journal: Acta crystallographica. Section E, Structure reports online20100901

Title: Cationic schiff base amphiphiles and their metal complexes: Surface and biocidal activities against bacteria and fungi.

Journal: Colloids and surfaces. B, Biointerfaces20100501

Title: (E)-1-(4-Chloro-phen-yl)-3-[4-(diethyl-amino)phen-yl]prop-2-en-1-one.

Journal: Acta crystallographica. Section E, Structure reports online20100201

Title: 4-Chloro-N-[4-(diethyl-amino)benzyl-idene]aniline.

Journal: Acta crystallographica. Section E, Structure reports online20100201

Title: Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling.

Journal: Neural development20100101

Title: 4-[4-(Diethyl-amino)benzyl-ideneamino]-4H-1,2,4-triazole.

Journal: Acta crystallographica. Section E, Structure reports online20080601

Title: Reactivity of the triple ion and separated ion pair of tris(trimethylsilyl)methyllithium with aldehydes: a RINMR study.

Journal: Journal of the American Chemical Society20080514

Title: Synthesis, acidity and antioxidant properties of some novel 3,4-disubstituted-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives.

Journal: Molecules (Basel, Switzerland)20080119

Title: Identification of a novel retinoid by small molecule screening with zebrafish embryos.

Journal: PloS one20080101

Title: Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy.

Journal: PloS one20080101

Title: Complex regulation of cyp26a1 creates a robust retinoic acid gradient in the zebrafish embryo.

Journal: PLoS biology20071101

Title: The cdx genes and retinoic acid control the positioning and segmentation of the zebrafish pronephros.

Journal: PLoS genetics20071001

Title: 4-(N,N-diethylamino) benzaldehyde thiosemicarbazone in the spectrophotometric determination of palladium.

Journal: Annali di chimica20071001

Title: Systemic bud induction and retinoic acid signaling underlie whole body regeneration in the urochordate Botrylloides leachi.

Journal: PLoS biology20070401

Title: Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish.

Journal: Developmental biology20070315

Title: Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development.

Journal: Development (Cambridge, England)20070101

Title: A screen for mutations in zebrafish that affect myelin gene expression in Schwann cells and oligodendrocytes.

Journal: Developmental biology20060901

Title: A novel cytochrome P450, zebrafish Cyp26D1, is involved in metabolism of all-trans retinoic acid.

Journal: Molecular endocrinology (Baltimore, Md.)20060701

Title: Retinoic acid activates myogenesis in vivo through Fgf8 signalling.

Journal: Developmental biology20060101

Title: Development and validation of an HPLC-UV method for the analysis of methoxyamine using 4-(diethylamino)benzaldehyde as a derivatizing agent.

Journal: Journal of pharmaceutical and biomedical analysis20050915

Title: Retionic acid and its receptors are required for expression of aryl hydrocarbon receptor mRNA and embryonic development of blood vessel and bone in the medaka fish, Oryzias latipes.

Journal: Zoological science20040501

Title: Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20031005

Title: 4-(N,N-dipropylamino)benzaldehyde inhibits the oxidation of all-trans retinal to all-trans retinoic acid by ALDH1A1, but not the differentiation of HL-60 promyelocytic leukemia cells exposed to all-trans retinal.

Journal: BMC pharmacology20020101

Title: Measurement of cytokine and adhesion molecule expression in synovial tissue by digital image analysis.

Journal: Annals of the rheumatic diseases20010301

Title: De novo expression of transfected human class 1 aldehyde dehydrogenase (ALDH) causes resistance to oxazaphosphorine anti-cancer alkylating agents in hamster V79 cell lines. Elevated class 1 ALDH activity is closely correlated with reduction in DNA interstrand cross-linking and lethality.

Journal: The Journal of biological chemistry19960517

Title: Luo M, et al. Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1. ACS Chem Biol. 2015 Mar 20;10(3):693-7.

Title: Araki N, et al. Screening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells. Toxicol In Vitro. 2005 Sep;19(6):831-42.

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