120667-15-4,MFCD02262122
Catalog No.:AA0075EE

120667-15-4 | (RS)-PPG

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$233.00   $163.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0075EE
Chemical Name:
(RS)-PPG
CAS Number:
120667-15-4
Molecular Formula:
C8H10NO5P
Molecular Weight:
231.1425
MDL Number:
MFCD02262122
SMILES:
OC(=O)C(c1ccc(cc1)P(=O)(O)O)N
Properties
Computed Properties
 
Complexity:
281  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-3.7  

Literature

Title: Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons.

Journal: Neurotoxicity research 20090801

Title: Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase A activation.

Journal: Aging cell 20080101

Title: Group III metabotropic glutamate receptor agonists selectively suppress excitatory synaptic currents in the rat prefrontal cortex induced by 5-hydroxytryptamine2A receptor activation.

Journal: The Journal of pharmacology and experimental therapeutics 20070101

Title: Neuroprotective effect of (R, S)-4-phosphonophenylglycine against neuronal damage associated with homocysteic acid-induced seizures in immature rats.

Journal: Prague medical report 20060101

Title: Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level.

Journal: Neuropharmacology 20050101

Title: (2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.

Journal: Journal of medicinal chemistry 20040115

Title: Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine.

Journal: Experimental neurology 20030301

Title: Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20011115

Title: Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.

Journal: European journal of pharmacology 20010720

Title: The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury.

Journal: Neurosurgery 20010501

Title: (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.

Journal: Neuropharmacology 20010301

Title: (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.

Journal: Bioorganic & medicinal chemistry letters 20000605

Title: (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 19990601

Title: Gasparini F, et al. (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87.

Title: Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide 1-35-treated cortical neurons. Neurotox Res. 2009 Aug;16(2):174-83.

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Tags:120667-15-4 Molecular Formula|120667-15-4 MDL|120667-15-4 SMILES|120667-15-4 (RS)-PPG
Catalog No.: AA0075EE
120667-15-4,MFCD02262122
120667-15-4 | (RS)-PPG
Pack Size: 1mg
Purity: 95%
1 week
$233.00 $163.00
Quantity
- +
Add to Card
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Technical Information
Catalog Number: AA0075EE
Chemical Name: (RS)-PPG
CAS Number: 120667-15-4
Molecular Formula: C8H10NO5P
Molecular Weight: 231.1425
MDL Number: MFCD02262122
SMILES: OC(=O)C(c1ccc(cc1)P(=O)(O)O)N
Properties
Complexity: 281  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 15  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: -3.7  
Literature fold

Title: Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide [31-35]-treated cortical neurons.

Journal: Neurotoxicity research20090801

Title: Amyloid beta-peptide 31-35-induced neuronal apoptosis is mediated by caspase-dependent pathways via cAMP-dependent protein kinase A activation.

Journal: Aging cell20080101

Title: Group III metabotropic glutamate receptor agonists selectively suppress excitatory synaptic currents in the rat prefrontal cortex induced by 5-hydroxytryptamine2A receptor activation.

Journal: The Journal of pharmacology and experimental therapeutics20070101

Title: Neuroprotective effect of (R, S)-4-phosphonophenylglycine against neuronal damage associated with homocysteic acid-induced seizures in immature rats.

Journal: Prague medical report20060101

Title: Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level.

Journal: Neuropharmacology20050101

Title: (2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.

Journal: Journal of medicinal chemistry20040115

Title: Seizures induced by homocysteic acid in immature rats are prevented by group III metabotropic glutamate receptoragonist (R,S)-4-phosphonophenylglycine.

Journal: Experimental neurology20030301

Title: Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20011115

Title: Anticonvulsant activity of a mGlu(4alpha) receptor selective agonist, (1S,3R,4S)-1-aminocyclopentane-1,2,4-tricarboxylic acid.

Journal: European journal of pharmacology20010720

Title: The effect of groups II and III metabotropic glutamate receptor activation on neuronal injury in a rodent model of traumatic brain injury.

Journal: Neurosurgery20010501

Title: (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.

Journal: Neuropharmacology20010301

Title: (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.

Journal: Bioorganic & medicinal chemistry letters20000605

Title: (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.

Journal: The Journal of pharmacology and experimental therapeutics19990601

Title: Gasparini F, et al. (R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87.

Title: Zhao L, et al. Activation of group III metabotropic glutamate receptor reduces intracellular calcium in beta-amyloid peptide 1-35-treated cortical neurons. Neurotox Res. 2009 Aug;16(2):174-83.

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