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1258861-20-9,MFCD21609264
Catalog No.:AA000OU8

1258861-20-9 | Ly2940680

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$88.00   $61.00
- +
5mg
98%
in stock  
$100.00   $70.00
- +
25mg
98%
in stock  
$267.00   $187.00
- +
100mg
98%
in stock  
$743.00   $520.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA000OU8
Chemical Name:
Ly2940680
CAS Number:
1258861-20-9
Molecular Formula:
C26H24F4N6O
Molecular Weight:
512.5020
MDL Number:
MFCD21609264
SMILES:
Fc1ccc(c(c1)C(F)(F)F)C(=O)N(C1CCN(CC1)c1nnc(c2c1cccc2)c1ccnn1C)C
Properties
Computed Properties
 
Complexity:
794  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.3  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10(11):e0142124.

Title: Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29(5):1817-29.

Title: Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

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SDS
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Tags:1258861-20-9 Molecular Formula|1258861-20-9 MDL|1258861-20-9 SMILES|1258861-20-9 Ly2940680
Catalog No.: AA000OU8
1258861-20-9,MFCD21609264
1258861-20-9 | Ly2940680
Pack Size： 1mg
Purity： ≥98%
in stock
$88.00 $61.00
Pack Size： 5mg
Purity： 98%
in stock
$100.00 $70.00
Pack Size： 25mg
Purity： 98%
in stock
$267.00 $187.00
Pack Size： 100mg
Purity： 98%
in stock
$743.00 $520.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA000OU8
Chemical Name: Ly2940680
CAS Number: 1258861-20-9
Molecular Formula: C26H24F4N6O
Molecular Weight: 512.5020
MDL Number: MFCD21609264
SMILES: Fc1ccc(c(c1)C(F)(F)F)C(=O)N(C1CCN(CC1)c1nnc(c2c1cccc2)c1ccnn1C)C
Properties
Complexity: 794  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 37  
Hydrogen Bond Acceptor Count: 9  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.3  
Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Fraveto A, et al, Sensitivity of Human Intrahepatic Cholangiocarcinoma Subtypes to Chemotherapeutics and Molecular Targeted Agents: A Study on Primary Cell Cultures. PLoS One. 2015 Nov 16;10(11):e0142124.

Title: Hoch L, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015 May;29(5):1817-29.

Title: Ma W, et al. Reduced Smoothened level rescued Aβ-induced memory deficits and neuronal inflammation in animal models of Alzheimer's disease. J Genet Genomics. 2018 May 20;45(5):237-246.

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