12627-35-9,MFCD00083465
Catalog No.:AA0080G8

12627-35-9 | Penitrem a

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$59.00   $41.00
- +
5mg
≥95%
in stock  
$218.00   $152.00
- +
10mg
≥95%
in stock  
$406.00   $284.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0080G8
Chemical Name:
Penitrem a
CAS Number:
12627-35-9
Molecular Formula:
C37H44ClNO6
Molecular Weight:
634.2014
MDL Number:
MFCD00083465
SMILES:
CC(=C)C1OC2CCC3(C(C42C(C1O)O4)(O)CCC1C3(C)c2[nH]c3c4c2C1OC(C)(C)C1C2(c4c(c(c3)Cl)CC(=C)C2C1)O)C
Properties
Computed Properties
 
Complexity:
1420  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
13  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.8  

Literature

Title: Hypoxia sensitivity of a voltage-gated potassium current in porcine intrapulmonary vein smooth muscle cells.

Journal: American journal of physiology. Lung cellular and molecular physiology 20120901

Title: Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function.

Journal: The Journal of pharmacology and experimental therapeutics 20120801

Title: In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system.

Journal: Neurochemistry international 20111201

Title: SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.

Journal: PLoS pathogens 20110401

Title: On being the right size: the impact of population size and stochastic effects on the evolution of drug resistance in hospitals and the community.

Journal: PLoS pathogens 20110401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Contribution of BK(Ca) channels to local metabolic coronary vasodilation: Effects of metabolic syndrome.

Journal: American journal of physiology. Heart and circulatory physiology 20100301

Title: Impaired function of coronary BK(Ca) channels in metabolic syndrome.

Journal: American journal of physiology. Heart and circulatory physiology 20091101

Title: Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels.

Journal: British journal of pharmacology 20090901

Title: Gender difference in BK channel expression in amygdala complex of rat brain.

Journal: Biochemical and biophysical research communications 20090123

Title: Toxin-produced Purkinje cell death: a model for neural stem cell transplantation studies.

Journal: Brain research 20080501

Title: LC-MS/MS screen for penitrem A and roquefortine C in serum and urine samples.

Journal: Analytical chemistry 20060701

Title: A-type potassium current in retinal arteriolar smooth muscle cells.

Journal: Investigative ophthalmology & visual science 20050901

Title: Comparison of secondary metabolite production by Penicillium crustosum strains, isolated from Arctic and other various ecological niches.

Journal: FEMS microbiology ecology 20050601

Title: Characterization of outward currents in interstitial cells from the guinea pig bladder.

Journal: The Journal of urology 20050101

Title: Radical and palladium-catalyzed cyclizations to cyclobutenes: an entry to the BCD ring system of penitrem D.

Journal: The Journal of organic chemistry 20040528

Title: Genotoxicity assessment of five tremorgenic mycotoxins (fumitremorgen B, paxilline, penitrem A, verruculogen, and verrucosidin) produced by molds isolated from fermented meats.

Journal: Journal of food protection 20031101

Title: New Penicillium species associated with bulbs and root vegetables.

Journal: Systematic and applied microbiology 20031101

Title: Tremorgenic indole alkaloids. The total synthesis of (-)-penitrem D.

Journal: Journal of the American Chemical Society 20030709

Title: Samarium(II) iodide mediated radical/polar crossover reactions of cyclobutenes. An efficient approach to the BCD ring system of the penitrems.

Journal: Organic letters 20030220

Title: Tremorgenic mycotoxins increase gastric smooth muscle activity of sheep reticulum and rumen in vitro.

Journal: Research in veterinary science 20030201

Title: Tremorgenic mycotoxin intoxication with penitrem A and roquefortine in two dogs.

Journal: Journal of the American Veterinary Medical Association 20030101

Title: Tremorgenic neuromycotoxicosis in 2 dogs ascribed to the ingestion of penitrem A and possibly roquefortine in rice contaminated with Penicillium crustosum.

Journal: Journal of the South African Veterinary Association 20021201

Title: Tremorgenic mycotoxicosis in four dogs from a single household.

Journal: Journal of the American Veterinary Medical Association 20021115

Title: Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5).

Title: Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34(1):33-42.

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Tags:12627-35-9 Molecular Formula|12627-35-9 MDL|12627-35-9 SMILES|12627-35-9 Penitrem a
Catalog No.: AA0080G8
12627-35-9,MFCD00083465
12627-35-9 | Penitrem a
Pack Size: 1mg
Purity: ≥95%
in stock
$59.00 $41.00
Pack Size: 5mg
Purity: ≥95%
in stock
$218.00 $152.00
Pack Size: 10mg
Purity: ≥95%
in stock
$406.00 $284.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0080G8
Chemical Name: Penitrem a
CAS Number: 12627-35-9
Molecular Formula: C37H44ClNO6
Molecular Weight: 634.2014
MDL Number: MFCD00083465
SMILES: CC(=C)C1OC2CCC3(C(C42C(C1O)O4)(O)CCC1C3(C)c2[nH]c3c4c2C1OC(C)(C)C1C2(c4c(c(c3)Cl)CC(=C)C2C1)O)C
Properties
Complexity: 1420  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 13  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 45  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.8  
Literature fold

Title: Hypoxia sensitivity of a voltage-gated potassium current in porcine intrapulmonary vein smooth muscle cells.

Journal: American journal of physiology. Lung cellular and molecular physiology20120901

Title: Penitrem A as a tool for understanding the role of large conductance Ca(2+)/voltage-sensitive K(+) channels in vascular function.

Journal: The Journal of pharmacology and experimental therapeutics20120801

Title: In vitro neuropharmacological evaluation of penitrem-induced tremorgenic syndromes: importance of the GABAergic system.

Journal: Neurochemistry international20111201

Title: SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants.

Journal: PLoS pathogens20110401

Title: On being the right size: the impact of population size and stochastic effects on the evolution of drug resistance in hospitals and the community.

Journal: PLoS pathogens20110401

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: Contribution of BK(Ca) channels to local metabolic coronary vasodilation: Effects of metabolic syndrome.

Journal: American journal of physiology. Heart and circulatory physiology20100301

Title: Impaired function of coronary BK(Ca) channels in metabolic syndrome.

Journal: American journal of physiology. Heart and circulatory physiology20091101

Title: Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels.

Journal: British journal of pharmacology20090901

Title: Gender difference in BK channel expression in amygdala complex of rat brain.

Journal: Biochemical and biophysical research communications20090123

Title: Toxin-produced Purkinje cell death: a model for neural stem cell transplantation studies.

Journal: Brain research20080501

Title: LC-MS/MS screen for penitrem A and roquefortine C in serum and urine samples.

Journal: Analytical chemistry20060701

Title: A-type potassium current in retinal arteriolar smooth muscle cells.

Journal: Investigative ophthalmology & visual science20050901

Title: Comparison of secondary metabolite production by Penicillium crustosum strains, isolated from Arctic and other various ecological niches.

Journal: FEMS microbiology ecology20050601

Title: Characterization of outward currents in interstitial cells from the guinea pig bladder.

Journal: The Journal of urology20050101

Title: Radical and palladium-catalyzed cyclizations to cyclobutenes: an entry to the BCD ring system of penitrem D.

Journal: The Journal of organic chemistry20040528

Title: Genotoxicity assessment of five tremorgenic mycotoxins (fumitremorgen B, paxilline, penitrem A, verruculogen, and verrucosidin) produced by molds isolated from fermented meats.

Journal: Journal of food protection20031101

Title: New Penicillium species associated with bulbs and root vegetables.

Journal: Systematic and applied microbiology20031101

Title: Tremorgenic indole alkaloids. The total synthesis of (-)-penitrem D.

Journal: Journal of the American Chemical Society20030709

Title: Samarium(II) iodide mediated radical/polar crossover reactions of cyclobutenes. An efficient approach to the BCD ring system of the penitrems.

Journal: Organic letters20030220

Title: Tremorgenic mycotoxins increase gastric smooth muscle activity of sheep reticulum and rumen in vitro.

Journal: Research in veterinary science20030201

Title: Tremorgenic mycotoxin intoxication with penitrem A and roquefortine in two dogs.

Journal: Journal of the American Veterinary Medical Association20030101

Title: Tremorgenic neuromycotoxicosis in 2 dogs ascribed to the ingestion of penitrem A and possibly roquefortine in rice contaminated with Penicillium crustosum.

Journal: Journal of the South African Veterinary Association20021201

Title: Tremorgenic mycotoxicosis in four dogs from a single household.

Journal: Journal of the American Veterinary Medical Association20021115

Title: Goda AA, et al. The Maxi-K (BK) Channel Antagonist Penitrem A as a Novel Breast Cancer-Targeted Therapeutic. Mar Drugs. 2018 May 11;16(5).

Title: Norris PJ, et al. Actions of tremorgenic fungal toxins on neurotransmitter release. J Neurochem. 1980 Jan;34(1):33-42.

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