Name: Name:2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide
Brand: AABLOCKS
SKU: AA000X5H
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA000X5H

Chemical Name: 2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide

CAS Number: 127625-29-0

Molecular Formula: C23H24FN3O2S

Molecular Weight: 425.5190

MDL Number: MFCD00866648

SMILES: Fc1ccc(cc1)N1CCN(CC1)CCCN1c2cccc3c2c(S1(=O)=O)ccc3

Properties

Complexity: 683

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 30

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 5

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4

Literature fold

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology20171201

Title: Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.

Journal: Journal of medicinal chemistry20090723

Title: Ordering and disordering of molecular solids upon mechanical milling: the case of fananserine.

Journal: Journal of pharmaceutical sciences20081101

Title: Molecular mobility in glass forming fananserine: a dielectric, NMR, and TMDSC investigation.

Journal: Pharmaceutical research20060401

Title: N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor.

Journal: Bioorganic & medicinal chemistry letters20051201

Title: [Thermodynamics of drug polymorphism: domains and stability hierarchy by pressure temperature diagram. Application to the tetramorphism of fananserine].

Journal: Annales pharmaceutiques francaises20020501

Title: 4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.

Journal: Journal of medicinal chemistry20020117

Title: Current and novel approaches to the drug treatment of schizophrenia.

Journal: Journal of medicinal chemistry20010215

Title: Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. Pharmacological characterization of [3H]RP 62203 binding in the rat brain.

Journal: European journal of pharmacology19930316

Title: Heuillet E, et al. The naphtosultam derivative RP 62203 (fananserin) has high affinity for the dopamine D4 receptor. Eur J Pharmacol. 1996 Oct 24;314(1-2):229-33.

Title: Malgouris C, et al. Autoradiographic studies of RP 62203, a potent 5-HT2 receptor antagonist. In vitro and ex vivo selectivity profile. Eur J Pharmacol. 1993 Mar 16;233(1):29-35.

Title: Stutzmann JM, et al. RP 62203, a 5-hydroxytryptamine2 antagonist, enhances deep NREM sleep in rats. Sleep. 1992 Apr;15(2):119-24.

127625-29-0 | 2H-Naphth[1,8-cd]isothiazole, 2-[3-[4-(4-fluorophenyl)-1-piperazinyl]propyl]-, 1,1-dioxide