Name: Name:2-(4-Methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidin-4-amine
Brand: AABLOCKS
SKU: AA000UVW
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA000UVW

Chemical Name: 2-(4-Methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidin-4-amine

CAS Number: 130800-90-7

Molecular Formula: C15H16Cl3N5

Molecular Weight: 372.6800

MDL Number: MFCD00867772

SMILES: CN1CCN(CC1)c1ncc(c(n1)N)c1cc(Cl)cc(c1Cl)Cl

Properties

Complexity: 393

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 23

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 2

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.6

Literature fold

Title: Oxadiazolylindazole sodium channel modulators are neuroprotective toward hippocampal neurones.

Journal: Journal of medicinal chemistry20090514

Title: Sipatrigine could have therapeutic potential for major depression and bipolar depression through antagonism of the two-pore-domain K+ channel TREK-1.

Journal: Medical hypotheses20080101

Title: The neuroprotective agent sipatrigine blocks multiple cardiac ion channels and causes triangulation of the ventricular action potential.

Journal: Clinical and experimental pharmacology & physiology20051201

Title: Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents.

Journal: European journal of pharmacology20030425

Title: Differential interactions of lamotrigine and related drugs with transmembrane segment IVS6 of voltage-gated sodium channels.

Journal: Neuropharmacology20030301

Title: Synthesis and structure-activity relationships of 6,7-benzomorphan derivatives as use-dependent sodium channel blockers for the treatment of stroke.

Journal: Journal of medicinal chemistry20020815

Title: Lamotrigine derivatives and riluzole inhibit INa,P in cortical neurons.

Journal: Neuroreport20020702

Title: Identification of a novel voltage-gated Na+ channel rNa(v)1.5a in the rat hippocampal progenitor stem cell line HiB5.

Journal: Pflugers Archiv : European journal of physiology20011001

Title: Effects of extracellular pH on the interaction of sipatrigine and lamotrigine with high-voltage-activated (HVA) calcium channels in dissociated neurones of rat cortex.

Journal: Neuropharmacology20010501

Title: The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 and TRAAK.

Journal: Brain research20010216

Title: Molecular determinants of voltage-dependent gating and binding of pore-blocking drugs in transmembrane segment IIIS6 of the Na(+) channel alpha subunit.

Journal: The Journal of biological chemistry20010105

Title: Leach MJ, et al. BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke. 1993 Jul;24(7):1063-7.

Title: Atticus H. Hainsworth, et al. Sipatrigine (BW 619C89) is a Neuroprotective Agent and a Sodium Channel and Calcium Channel Inhibitor. CNS Drug Reviews. Vol. 6, No. 2, pp. 111-134.

130800-90-7 | 2-(4-Methylpiperazin-1-yl)-5-(2,3,5-trichlorophenyl)pyrimidin-4-amine