133081-24-0,MFCD03788692
Catalog No.:AA001458

133081-24-0 | 6-Hydrazinonicotinic acid

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1g
95%
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$18.00   $13.00
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5g
95%
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$23.00   $16.00
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25g
96%
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$108.00   $76.00
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100g
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001458
Chemical Name:
6-Hydrazinonicotinic acid
CAS Number:
133081-24-0
Molecular Formula:
C6H7N3O2
Molecular Weight:
153.1387
MDL Number:
MFCD03788692
SMILES:
NNc1ccc(cn1)C(=O)O
Properties
Computed Properties
 
Complexity:
151  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-2.3  

Literature

Title: 6-Hydrazinylnicotinic acid: a powder study.

Journal: Acta crystallographica. Section E, Structure reports online 20120301

Title: Synthesis and evaluation of analogues of HYNIC as bifunctional chelators for technetium.

Journal: Dalton transactions (Cambridge, England : 2003) 20110621

Title: Preparation of catalytically active, covalent α-polylysine-enzyme conjugates via UV/vis-quantifiable bis-aryl hydrazone bond formation.

Journal: Biomacromolecules 20110110

Title: Neurotensin(8-13) analogue: radiolabeling and biological evaluation using different chelators.

Journal: Nuclear medicine and biology 20110101

Title: Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20101201

Title: Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.

Journal: European journal of nuclear medicine and molecular imaging 20101101

Title: Gd-EDDA/HYNIC-RGD as an MR molecular probe imaging integrin alphanubeta3 receptor-expressed tumor-MR molecular imaging of angiogenesis.

Journal: European journal of radiology 20100201

Title: Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma.

Journal: PloS one 20100101

Title: Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20091001

Title: Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.

Journal: Biological & pharmaceutical bulletin 20090701

Title: Clinical evaluation of antimicrobial peptide [(99m)Tc/Tricine/HYNIC(0)]ubiquicidin 29-41 as a human-specific infection imaging agent.

Journal: Nuclear medicine and biology 20090201

Title: Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20081001

Title: Breast tumor targeting with (99m)Tc-HYNIC-PR81 complex as a new biologic radiopharmaceutical.

Journal: Nuclear medicine and biology 20081001

Title: 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080801

Title: Radiolabeling of annexin A5 with (99m)Tc: comparison of HYNIC-Tc vs. iminothiolane-Tc-tricarbonyl conjugates.

Journal: Nuclear medicine and biology 20080801

Title: Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NETs.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20080701

Title: A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions.

Journal: Dalton transactions (Cambridge, England : 2003) 20080614

Title: Label-free detection of biomolecular interactions in real time with a nano-porous silicon-based detection method.

Journal: Proteome science 20080101

Title: Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20071101

Title: Two peptide receptor ligands (99m)Tc-EDDA/HYNIC-Tyr(3)-octreotide and (99m)Tc-EDDA/HYNIC-(D)Glu-octagastrin for scintigraphy of medullary thyroid carcinoma.

Journal: Cancer biotherapy & radiopharmaceuticals 20071001

Title: Preclinical evaluation of [99mTc/EDDA/tricine/HYNIC0, 1-Nal3, Thr8]-octreotide as a new analogue in the detection of somatostatin-receptor-positive tumors.

Journal: Nuclear medicine and biology 20070801

Title: Confirmation of hydrazone formation in HYNIC-peptide conjugate preparation, and its hydrolysis during labeling with (99m)Tc.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20070701

Title: Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.

Journal: Bioorganic & medicinal chemistry letters 20070615

Title: Labeling biomolecules with radiorhenium: a review of the bifunctional chelators.

Journal: Anti-cancer agents in medicinal chemistry 20070501

Title: Trifluoroacetyl-HYNIC peptides: synthesis and 99mTc radiolabeling.

Journal: Journal of medicinal chemistry 20070322

Title: 99mTc-EDDA/HYNIC-octreotate in detection of atypical bronchial carcinoid.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20070101

Title: Synthesis of oxytocin HYNIC derivatives as potential diagnostic agents for breast cancer.

Journal: Bioconjugate chemistry 20070101

Title: Labelling of the anti-III-neurotubulin monoclonal antibody by 99mTc and its binding to responsible antigen.

Journal: Nuclear medicine review. Central & Eastern Europe 20070101

Title: The effect of Tc-99m-labeled MDM2 antisense oligonucleotide on gene expression in human breast cancer MCF-7 cells.

Journal: Journal of experimental therapeutics & oncology 20070101

Title: Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20061201

Title: [99mTc]HYNIC-RGD for imaging integrin alphavbeta3 expression.

Journal: Nuclear medicine and biology 20061101

Title: An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK).

Journal: Nuclear medicine and biology 20060701

Title: Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia.

Journal: Neurology 20060425

Title: Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease.

Journal: Cancer biotherapy & radiopharmaceuticals 20060401

Title: Chemoselective hydrazone formation between HYNIC-functionalized peptides and (18)F-fluorinated aldehydes.

Journal: Nuclear medicine and biology 20060201

Title: A novel ternary ligand system useful for preparation of cationic (99m)Tc-diazenido complexes and (99m)Tc-labeling of small biomolecules.

Journal: Bioconjugate chemistry 20060101

Title: Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci.

Journal: Journal of medicinal chemistry 20051006

Title: Evaluation of [99mTc/EDDA/HYNIC0]octreotide derivatives compared with [111In-DOTA0,Tyr3, Thr8]octreotide and [111In-DTPA0]octreotide: does tumor or pancreas uptake correlate with the rate of internalization?

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050901

Title: [99mTc] HYNIC-hEGF, a potential agent for imaging of EGF receptors in vivo: preparation and pre-clinical evaluation.

Journal: Oncology reports 20050601

Title: Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans.

Journal: Circulation 20050118

Title: 99mTc-labeled mannosyl-neoglycoalbumin for sentinel lymph node identification.

Journal: Nuclear medicine and biology 20041001

Title: Intratumoral injection of 188Re labeled cationic polyethylenimine conjugates: a preliminary report.

Journal: Journal of Korean medical science 20041001

Title: Intraobserver, interobserver, and day-to-day reproducibility of quantitative 99mTc-HYNIC annexin-V imaging in head and neck carcinoma.

Journal: Cancer biotherapy & radiopharmaceuticals 20040401

Title: 99mTc-Hynic-Annexin V. North American Scientific.

Journal: IDrugs : the investigational drugs journal 20040301

Title: 99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Nalpha-His)acetic acid-modified [D-Glu1]-minigastrin.

Journal: Bioconjugate chemistry 20040101

Title: Lys and Arg in UBI: a specific site for a stable Tc-99m complex?

Journal: Nuclear medicine and biology 20030801

Title: Solid-phase synthesis of peptide radiopharmaceuticals using Fmoc-N-epsilon-(hynic-Boc)-lysine, a technetium-binding amino acid: application to Tc-99m-labeled salmon calcitonin.

Journal: Journal of medicinal chemistry 20030424

Title: In vitro cell studies of technetium-99m labeled RGD-HYNIC peptide, a comparison of tricine and EDDA as co-ligands.

Journal: Nuclear medicine and biology 20030201

Title: Phosphine-containing HYNIC derivatives as potential bifunctional chelators for (99m)Tc-labeling of small biomolecules.

Journal: Bioconjugate chemistry 20030101

Title: Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide.

Journal: Nuclear medicine and biology 20020101

Title: Control of radioactivity pharmacokinetics of 99mTc-HYNIC-labeled polypeptides derivatized with ternary ligand complexes.

Journal: Bioconjugate chemistry 20020101

Title: In vitro and in vivo evaluation of a Technetium-99m-labeled cyclic RGD peptide as a specific marker of alpha(V)beta(3) integrin for tumor imaging.

Journal: Bioconjugate chemistry 20020101

Title: Specific and rapid scintigraphic detection of infection with 99mTc-labeled interleukin-8.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20010101

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Tags:133081-24-0 Molecular Formula|133081-24-0 MDL|133081-24-0 SMILES|133081-24-0 6-Hydrazinonicotinic acid
Catalog No.: AA001458
133081-24-0,MFCD03788692
133081-24-0 | 6-Hydrazinonicotinic acid
Pack Size: 250mg
Purity: 95%
in stock
$6.00 $4.00
Pack Size: 1g
Purity: 95%
in stock
$18.00 $13.00
Pack Size: 5g
Purity: 95%
in stock
$23.00 $16.00
Pack Size: 25g
Purity: 96%
in stock
$108.00 $76.00
Pack Size: 100g
Purity: 96%
in stock
$397.00 $278.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001458
Chemical Name: 6-Hydrazinonicotinic acid
CAS Number: 133081-24-0
Molecular Formula: C6H7N3O2
Molecular Weight: 153.1387
MDL Number: MFCD03788692
SMILES: NNc1ccc(cn1)C(=O)O
Properties
Complexity: 151  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 11  
Hydrogen Bond Acceptor Count: 5  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -2.3  
Literature fold

Title: 6-Hydrazinylnicotinic acid: a powder study.

Journal: Acta crystallographica. Section E, Structure reports online20120301

Title: Synthesis and evaluation of analogues of HYNIC as bifunctional chelators for technetium.

Journal: Dalton transactions (Cambridge, England : 2003)20110621

Title: Preparation of catalytically active, covalent α-polylysine-enzyme conjugates via UV/vis-quantifiable bis-aryl hydrazone bond formation.

Journal: Biomacromolecules20110110

Title: Neurotensin(8-13) analogue: radiolabeling and biological evaluation using different chelators.

Journal: Nuclear medicine and biology20110101

Title: Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20101201

Title: Imaging with radiolabelled anti-membrane type 1 matrix metalloproteinase (MT1-MMP) antibody: potentials for characterizing atherosclerotic plaques.

Journal: European journal of nuclear medicine and molecular imaging20101101

Title: Gd-EDDA/HYNIC-RGD as an MR molecular probe imaging integrin alphanubeta3 receptor-expressed tumor-MR molecular imaging of angiogenesis.

Journal: European journal of radiology20100201

Title: Changes in vascular permeability and expression of different angiogenic factors following anti-angiogenic treatment in rat glioma.

Journal: PloS one20100101

Title: Radiolabeled humanized anti-CD3 monoclonal antibody visilizumab for imaging human T-lymphocytes.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20091001

Title: Development of a radiolabeled probe for detecting membrane type-1 matrix metalloproteinase on malignant tumors.

Journal: Biological & pharmaceutical bulletin20090701

Title: Clinical evaluation of antimicrobial peptide [(99m)Tc/Tricine/HYNIC(0)]ubiquicidin 29-41 as a human-specific infection imaging agent.

Journal: Nuclear medicine and biology20090201

Title: Targeting of lectinlike oxidized low-density lipoprotein receptor 1 (LOX-1) with 99mTc-labeled anti-LOX-1 antibody: potential agent for imaging of vulnerable plaque.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20081001

Title: Breast tumor targeting with (99m)Tc-HYNIC-PR81 complex as a new biologic radiopharmaceutical.

Journal: Nuclear medicine and biology20081001

Title: 99mTc-labeled duramycin as a novel phosphatidylethanolamine-binding molecular probe.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20080801

Title: Radiolabeling of annexin A5 with (99m)Tc: comparison of HYNIC-Tc vs. iminothiolane-Tc-tricarbonyl conjugates.

Journal: Nuclear medicine and biology20080801

Title: Initial direct comparison of 99mTc-TOC and 99mTc-TATE in identifying sites of disease in patients with proven GEP NETs.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20080701

Title: A technetium intermediate specifically promotes deprotection of trifluoroacetyl HYNIC during radiolabelling under mild conditions.

Journal: Dalton transactions (Cambridge, England : 2003)20080614

Title: Label-free detection of biomolecular interactions in real time with a nano-porous silicon-based detection method.

Journal: Proteome science20080101

Title: Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20071101

Title: Two peptide receptor ligands (99m)Tc-EDDA/HYNIC-Tyr(3)-octreotide and (99m)Tc-EDDA/HYNIC-(D)Glu-octagastrin for scintigraphy of medullary thyroid carcinoma.

Journal: Cancer biotherapy & radiopharmaceuticals20071001

Title: Preclinical evaluation of [99mTc/EDDA/tricine/HYNIC0, 1-Nal3, Thr8]-octreotide as a new analogue in the detection of somatostatin-receptor-positive tumors.

Journal: Nuclear medicine and biology20070801

Title: Confirmation of hydrazone formation in HYNIC-peptide conjugate preparation, and its hydrolysis during labeling with (99m)Tc.

Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine20070701

Title: Technetium-99m-labeling and synthesis of thymidine analogs: potential candidates for tumor imaging.

Journal: Bioorganic & medicinal chemistry letters20070615

Title: Labeling biomolecules with radiorhenium: a review of the bifunctional chelators.

Journal: Anti-cancer agents in medicinal chemistry20070501

Title: Trifluoroacetyl-HYNIC peptides: synthesis and 99mTc radiolabeling.

Journal: Journal of medicinal chemistry20070322

Title: 99mTc-EDDA/HYNIC-octreotate in detection of atypical bronchial carcinoid.

Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association20070101

Title: Synthesis of oxytocin HYNIC derivatives as potential diagnostic agents for breast cancer.

Journal: Bioconjugate chemistry20070101

Title: Labelling of the anti-III-neurotubulin monoclonal antibody by 99mTc and its binding to responsible antigen.

Journal: Nuclear medicine review. Central & Eastern Europe20070101

Title: The effect of Tc-99m-labeled MDM2 antisense oligonucleotide on gene expression in human breast cancer MCF-7 cells.

Journal: Journal of experimental therapeutics & oncology20070101

Title: Development of a novel 99mTc-chelate-conjugated bisphosphonate with high affinity for bone as a bone scintigraphic agent.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20061201

Title: [99mTc]HYNIC-RGD for imaging integrin alphavbeta3 expression.

Journal: Nuclear medicine and biology20061101

Title: An improved method of 18F peptide labeling: hydrazone formation with HYNIC-conjugated c(RGDyK).

Journal: Nuclear medicine and biology20060701

Title: Annexin V SPECT imaging of phosphatidylserine expression in patients with dementia.

Journal: Neurology20060425

Title: Radiolabeled melanin-binding peptides are safe and effective in treatment of human pigmented melanoma in a mouse model of disease.

Journal: Cancer biotherapy & radiopharmaceuticals20060401

Title: Chemoselective hydrazone formation between HYNIC-functionalized peptides and (18)F-fluorinated aldehydes.

Journal: Nuclear medicine and biology20060201

Title: A novel ternary ligand system useful for preparation of cationic (99m)Tc-diazenido complexes and (99m)Tc-labeling of small biomolecules.

Journal: Bioconjugate chemistry20060101

Title: Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci.

Journal: Journal of medicinal chemistry20051006

Title: Evaluation of [99mTc/EDDA/HYNIC0]octreotide derivatives compared with [111In-DOTA0,Tyr3, Thr8]octreotide and [111In-DTPA0]octreotide: does tumor or pancreas uptake correlate with the rate of internalization?

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20050901

Title: [99mTc] HYNIC-hEGF, a potential agent for imaging of EGF receptors in vivo: preparation and pre-clinical evaluation.

Journal: Oncology reports20050601

Title: Annexin A5 scintigraphy of forearm as a novel in vivo model of skeletal muscle preconditioning in humans.

Journal: Circulation20050118

Title: 99mTc-labeled mannosyl-neoglycoalbumin for sentinel lymph node identification.

Journal: Nuclear medicine and biology20041001

Title: Intratumoral injection of 188Re labeled cationic polyethylenimine conjugates: a preliminary report.

Journal: Journal of Korean medical science20041001

Title: Intraobserver, interobserver, and day-to-day reproducibility of quantitative 99mTc-HYNIC annexin-V imaging in head and neck carcinoma.

Journal: Cancer biotherapy & radiopharmaceuticals20040401

Title: 99mTc-Hynic-Annexin V. North American Scientific.

Journal: IDrugs : the investigational drugs journal20040301

Title: 99mTc-labeling and in vitro and in vivo evaluation of HYNIC- and (Nalpha-His)acetic acid-modified [D-Glu1]-minigastrin.

Journal: Bioconjugate chemistry20040101

Title: Lys and Arg in UBI: a specific site for a stable Tc-99m complex?

Journal: Nuclear medicine and biology20030801

Title: Solid-phase synthesis of peptide radiopharmaceuticals using Fmoc-N-epsilon-(hynic-Boc)-lysine, a technetium-binding amino acid: application to Tc-99m-labeled salmon calcitonin.

Journal: Journal of medicinal chemistry20030424

Title: In vitro cell studies of technetium-99m labeled RGD-HYNIC peptide, a comparison of tricine and EDDA as co-ligands.

Journal: Nuclear medicine and biology20030201

Title: Phosphine-containing HYNIC derivatives as potential bifunctional chelators for (99m)Tc-labeling of small biomolecules.

Journal: Bioconjugate chemistry20030101

Title: Nitriles form mixed-coligand complexes with (99m)Tc-HYNIC-peptide.

Journal: Nuclear medicine and biology20020101

Title: Control of radioactivity pharmacokinetics of 99mTc-HYNIC-labeled polypeptides derivatized with ternary ligand complexes.

Journal: Bioconjugate chemistry20020101

Title: In vitro and in vivo evaluation of a Technetium-99m-labeled cyclic RGD peptide as a specific marker of alpha(V)beta(3) integrin for tumor imaging.

Journal: Bioconjugate chemistry20020101

Title: Specific and rapid scintigraphic detection of infection with 99mTc-labeled interleukin-8.

Journal: Journal of nuclear medicine : official publication, Society of Nuclear Medicine20010101

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