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1375465-09-0,MFCD26142654
Catalog No.:AA009C7T

1375465-09-0 | Cnx-2006

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$53.00   $37.00
- +
5mg
in stock  
$227.00   $159.00
- +
10mg
≥98%
in stock  
$405.00   $283.00
- +
25mg
in stock  
$599.00   $419.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA009C7T
Chemical Name:
Cnx-2006
CAS Number:
1375465-09-0
Molecular Formula:
C26H27F4N7O2
Molecular Weight:
545.5319
MDL Number:
MFCD26142654
SMILES:
FCCN1CC(C1)Nc1ccc(c(c1)OC)Nc1ncc(c(n1)Nc1cccc(c1)NC(=O)C=C)C(F)(F)F
Properties
Computed Properties
 
Complexity:
801  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
11  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.8  

Literature

Title: Galvani E, et al. Abstract 3244: Role of epithelial-mesenchymal transition (EMT) in sensitivity to CNX-2006, a novel mutant-selective EGFR inhibitor which overcomes in vitro T790M-mediated resistance in NSCLC. CNX-2006, a novel mutant-selective EGFR inhibitor which overcomes in vitro T790M-mediated resistance in NSCLC. [abstract In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Ishington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 3244. doi:10.1158/1538-7445.AM2013-3244

Title: Ohashi K, et al. Abstract 2101A: CNX-2006, a novel irreversible epidermal growth factor receptor (EGFR) inhibitor, selectively inhibits EGFR T790M and fails to induce T790M-mediated resistance in vitro. [abstract In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Ishington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2101A. doi:10.1158/1538-7445.AM2013-2101A

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SDS
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Tags:1375465-09-0 Molecular Formula|1375465-09-0 MDL|1375465-09-0 SMILES|1375465-09-0 Cnx-2006
Catalog No.: AA009C7T
1375465-09-0,MFCD26142654
1375465-09-0 | Cnx-2006
Pack Size： 1mg
Purity： ≥98%
in stock
$53.00 $37.00
Pack Size： 5mg
Purity：
in stock
$227.00 $159.00
Pack Size： 10mg
Purity： ≥98%
in stock
$405.00 $283.00
Pack Size： 25mg
Purity：
in stock
$599.00 $419.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA009C7T
Chemical Name: Cnx-2006
CAS Number: 1375465-09-0
Molecular Formula: C26H27F4N7O2
Molecular Weight: 545.5319
MDL Number: MFCD26142654
SMILES: FCCN1CC(C1)Nc1ccc(c(c1)OC)Nc1ncc(c(n1)Nc1cccc(c1)NC(=O)C=C)C(F)(F)F
Properties
Complexity: 801  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 39  
Hydrogen Bond Acceptor Count: 12  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 11  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.8  
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