Name: Name:Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)
Brand: AABLOCKS
SKU: AA001ES8
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA001ES8

Chemical Name: Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)

CAS Number: 147366-41-4

Molecular Formula: C21H22ClN3OS2

Molecular Weight: 432.0019

MDL Number: MFCD00953420

SMILES: CCn1c(=Cc2cccc[n+]2CC)sc(=c2sc3c(n2C)cccc3)c1=O.[Cl-]

Properties

Complexity: 647

Covalently-Bonded Unit Count: 2

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 2

Formal Charge: 0

Heavy Atom Count: 28

Hydrogen Bond Acceptor Count: 5

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Literature fold

Title: Withanone binds to mortalin and abrogates mortalin-p53 complex: computational and experimental evidence.

Journal: The international journal of biochemistry & cell biology20120301

Title: Uptake rate of cationic mitochondrial inhibitor MKT-077 determines cellular oxygen consumption change in carcinoma cells.

Journal: PloS one20120101

Title: Mortalin inhibition in experimental Parkinson's disease.

Journal: Movement disorders : official journal of the Movement Disorder Society20110801

Title: Mortalin inhibitors sensitize K562 leukemia cells to complement-dependent cytotoxicity.

Journal: International journal of cancer20100315

Title: Fluorinated rhodacyanine (SJL-01) possessing high efficacy for visceral leishmaniasis (VL).

Journal: Journal of medicinal chemistry20100114

Title: The selective in vitro cytotoxicity of carcinoma cells by AZT is enhanced by concurrent treatment with delocalized lipophilic cations.

Journal: Cancer letters20030730

Title: Potentiation of the antiproliferative activity of MKT-077 by loperamide, diltiazem and tamoxifen.

Journal: Oncology reports20030101

Title: Mortalin: a potential candidate for biotechnology and biomedicine.

Journal: Histology and histopathology20021001

Title: Starenki D, et al. Selective Mitochondrial Uptake of MKT-077 Can Suppress Medullary Thyroid Carcinoma Cell Survival In Vitro and In Vivo. Endocrinol Metab (Seoul). 2015 Dec;30(4):593-603.

Title: Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11).

Title: Weisberg EL, et al. In vivo administration of MKT-077 causes partial yet reversible impairment of mitochondrial function. Cancer Res. 1996 Feb 1;56(3):551-5.

147366-41-4 | Pyridinium, 1-ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-, chloride (1:1)