152239-46-8,MFCD00923644
Catalog No.:AA00AK1D

152239-46-8 | SB 204741

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
≥95%
in stock  
$110.00   $77.00
- +
50mg
≥95%
in stock  
$438.00   $306.00
- +
100mg
≥95%
in stock  
$603.00   $422.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00AK1D
Chemical Name:
SB 204741
CAS Number:
152239-46-8
Molecular Formula:
C14H14N4OS
Molecular Weight:
286.3522
MDL Number:
MFCD00923644
SMILES:
O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C
Properties
Computed Properties
 
Complexity:
367  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
2  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.4  

Literature

Title: 5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.

Journal: Journal of molecular and cellular cardiology 20121101

Title: Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT(2A) receptor-dependent pathway.

Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20120101

Title: Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

Journal: Nature medicine 20111127

Title: The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease.

Journal: The Journal of pharmacology and experimental therapeutics 20110701

Title: Role of 5-HT 2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats.

Journal: Clinical and experimental pharmacology & physiology 20100701

Title: A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20100201

Title: Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.

Journal: Psychopharmacology 20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.

Journal: Psychopharmacology 20081201

Title: 5-HT(2) receptor subtypes mediate different long-term changes in GABAergic activity to parasympathetic cardiac vagal neurons in the nucleus ambiguus.

Journal: Neuroscience 20071109

Title: Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors.

Journal: Gastroenterology 20070901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats.

Journal: Psychopharmacology 20060101

Title: Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses.

Journal: The Journal of pharmacology and experimental therapeutics 20040901

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20040801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

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Related Products of 152239-46-8
Tags:152239-46-8 Molecular Formula|152239-46-8 MDL|152239-46-8 SMILES|152239-46-8 SB 204741
Catalog No.: AA00AK1D
152239-46-8,MFCD00923644
152239-46-8 | SB 204741
Pack Size: 10mg
Purity: ≥95%
in stock
$110.00 $77.00
Pack Size: 50mg
Purity: ≥95%
in stock
$438.00 $306.00
Pack Size: 100mg
Purity: ≥95%
in stock
$603.00 $422.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00AK1D
Chemical Name: SB 204741
CAS Number: 152239-46-8
Molecular Formula: C14H14N4OS
Molecular Weight: 286.3522
MDL Number: MFCD00923644
SMILES: O=C(Nc1snc(c1)C)Nc1ccc2c(c1)ccn2C
Properties
Complexity: 367  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 2  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.4  
Literature fold

Title: 5-HT(2B) antagonism arrests non-canonical TGF-β1-induced valvular myofibroblast differentiation.

Journal: Journal of molecular and cellular cardiology20121101

Title: Elevated cyclic stretch and serotonin result in altered aortic valve remodeling via a mechanosensitive 5-HT(2A) receptor-dependent pathway.

Journal: Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology20120101

Title: Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.

Journal: Nature medicine20111127

Title: The bulky N6 substituent of cabergoline is responsible for agonism of this drug at 5-hydroxytryptamine 5-HT2A and 5-HT2B receptors and thus is a determinant of valvular heart disease.

Journal: The Journal of pharmacology and experimental therapeutics20110701

Title: Role of 5-HT 2B receptors in cardiomyocyte apoptosis in noradrenaline-induced cardiomyopathy in rats.

Journal: Clinical and experimental pharmacology & physiology20100701

Title: A selective, high affinity 5-HT 2B receptor antagonist inhibits visceral hypersensitivity in rats.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20100201

Title: Chronic treatment of astrocytes with therapeutically relevant fluoxetine concentrations enhances cPLA2 expression secondary to 5-HT2B-induced, transactivation-mediated ERK1/2 phosphorylation.

Journal: Psychopharmacology20091101

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: Fluoxetine-mediated 5-HT2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation.

Journal: Psychopharmacology20081201

Title: 5-HT(2) receptor subtypes mediate different long-term changes in GABAergic activity to parasympathetic cardiac vagal neurons in the nucleus ambiguus.

Journal: Neuroscience20071109

Title: Exogenous serotonin regulates proliferation of interstitial cells of Cajal in mouse jejunum through 5-HT2B receptors.

Journal: Gastroenterology20070901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats.

Journal: Psychopharmacology20060101

Title: Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses.

Journal: The Journal of pharmacology and experimental therapeutics20040901

Title: Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20040801

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

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