156722-18-8,MFCD00927279
Catalog No.:AA001OUB

156722-18-8 | 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$133.00   $93.00
- +
10mg
≥98%
in stock  
$242.00   $169.00
- +
25mg
≥98%
in stock  
$545.00   $381.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001OUB
Chemical Name:
24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-
CAS Number:
156722-18-8
Molecular Formula:
C23H34O4
Molecular Weight:
374.5137
MDL Number:
MFCD00927279
SMILES:
O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@]1(O)CC[C@]2(O)c1ccoc1)C)C
Properties
Computed Properties
 
Complexity:
609  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.3  

Literature

Title: Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.

Journal: Trials 20110101

Title: Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.

Journal: Biochimica et biophysica acta 20101201

Title: Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies.

Journal: Science translational medicine 20101124

Title: Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.

Journal: Science translational medicine 20101124

Title: Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.

Journal: Medical hypotheses 20070101

Title: Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20061230

Title: Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.

Journal: Kidney international 20060601

Title: Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20060301

Title: A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin.

Journal: Cardiovascular & hematological agents in medicinal chemistry 20060101

Title: Adducin and hypertension.

Journal: Pharmacogenomics 20051001

Title: OASIS-HT: design of a pharmacogenomic dose-finding study.

Journal: Pharmacogenomics 20051001

Title: PST 2238 as an antihypertensive compound that antagonizes the effect of endogenous cardiac glycosides.

Journal: Acta poloniae pharmaceutica 20050101

Title: Ouabain antagonists as antihypertensive agents.

Journal: Current pharmaceutical design 20050101

Title: Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238.

Journal: The Journal of biological chemistry 20040806

Title: Antihypertensive compounds that modulate the Na-K pump.

Journal: Annals of the New York Academy of Sciences 20030401

Title: Genes and hypertension.

Journal: Current pharmaceutical design 20030101

Title: PST 2238: a new antihypertensive compound that modulates renal Na-K pump function without diuretic activity in Milan hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20021201

Title: Endogenous cardiotonic steroids.

Journal: Cellular and molecular biology (Noisy-le-Grand, France) 20010301

Title: Quadri L, et al. 17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action. J Med Chem. 1997 May 23;40(11):1561-4.

Title: Ferrari P, et al. PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol Exp Ther. 1999 Mar;288(3):1074-83.

Title: Matthias Lingemann, et al. The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PLoS Pathog. 2019 Aug 5;15(8):e1007963.

Title: Camilla F Wenceslau, et al. Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+,K+-ATPase/cSRC pathway. J Hypertens. 2014 Mar;32(3):542-54.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 156722-18-8
Tags:156722-18-8 Molecular Formula|156722-18-8 MDL|156722-18-8 SMILES|156722-18-8 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-
Catalog No.: AA001OUB
156722-18-8,MFCD00927279
156722-18-8 | 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-
Pack Size: 1mg
Purity: ≥98%
in stock
$46.00 $32.00
Pack Size: 5mg
Purity: ≥98%
in stock
$133.00 $93.00
Pack Size: 10mg
Purity: ≥98%
in stock
$242.00 $169.00
Pack Size: 25mg
Purity: ≥98%
in stock
$545.00 $381.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001OUB
Chemical Name: 24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-
CAS Number: 156722-18-8
Molecular Formula: C23H34O4
Molecular Weight: 374.5137
MDL Number: MFCD00927279
SMILES: O[C@H]1CC[C@]2([C@@H](C1)CC[C@@H]1[C@@H]2CC[C@]2([C@]1(O)CC[C@]2(O)c1ccoc1)C)C
Properties
Complexity: 609  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 8  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 27  
Hydrogen Bond Acceptor Count: 4  
Hydrogen Bond Donor Count: 3  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.3  
Literature fold

Title: Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.

Journal: Trials20110101

Title: Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.

Journal: Biochimica et biophysica acta20101201

Title: Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies.

Journal: Science translational medicine20101124

Title: Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.

Journal: Science translational medicine20101124

Title: Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.

Journal: Medical hypotheses20070101

Title: Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20061230

Title: Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.

Journal: Kidney international20060601

Title: Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology20060301

Title: A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin.

Journal: Cardiovascular & hematological agents in medicinal chemistry20060101

Title: Adducin and hypertension.

Journal: Pharmacogenomics20051001

Title: OASIS-HT: design of a pharmacogenomic dose-finding study.

Journal: Pharmacogenomics20051001

Title: PST 2238 as an antihypertensive compound that antagonizes the effect of endogenous cardiac glycosides.

Journal: Acta poloniae pharmaceutica20050101

Title: Ouabain antagonists as antihypertensive agents.

Journal: Current pharmaceutical design20050101

Title: Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238.

Journal: The Journal of biological chemistry20040806

Title: Antihypertensive compounds that modulate the Na-K pump.

Journal: Annals of the New York Academy of Sciences20030401

Title: Genes and hypertension.

Journal: Current pharmaceutical design20030101

Title: PST 2238: a new antihypertensive compound that modulates renal Na-K pump function without diuretic activity in Milan hypertensive rats.

Journal: Journal of cardiovascular pharmacology20021201

Title: Endogenous cardiotonic steroids.

Journal: Cellular and molecular biology (Noisy-le-Grand, France)20010301

Title: Quadri L, et al. 17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action. J Med Chem. 1997 May 23;40(11):1561-4.

Title: Ferrari P, et al. PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension. J Pharmacol Exp Ther. 1999 Mar;288(3):1074-83.

Title: Matthias Lingemann, et al. The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. PLoS Pathog. 2019 Aug 5;15(8):e1007963.

Title: Camilla F Wenceslau, et al. Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+,K+-ATPase/cSRC pathway. J Hypertens. 2014 Mar;32(3):542-54.

Building Blocks More >
157116-68-2
157116-68-2
L-Leucine, N-(cyclohexylcarbonyl)-
AA001P5B | MFCD16377985
157503-18-9
157503-18-9
6-Maleimido-1-hexanol
AA001PEY | MFCD16251432
15789-04-5
15789-04-5
N,N-Diethyl-3-hydroxybenzamide
AA001PPW | MFCD11130615
15827-56-2
15827-56-2
Cis-1,4-cyclohexanediamine
AA001Q06 | MFCD08276323
158619-46-6
158619-46-6
3'-Methylbiphenyl-3-carboxylic acid
AA001QA2 | MFCD00558892
1593969-81-3
1593969-81-3
tert-Butyl n-[(3s,5s)-5-fluoropiperidin-3-yl]carbamate
AA001QL0 | MFCD24849798
158861-24-6
158861-24-6
3-(Piperidin-1-ylmethyl)benzoic acid
AA001QWG | MFCD05841589
15962-47-7
15962-47-7
Ac-ala-nh2
AA001R66 | MFCD00080821
159855-98-8
159855-98-8
L-Alanine, N-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-
AA001RDD | MFCD01052846
160191-58-2
160191-58-2
3-Aminocyclobutanecarboxylic acid
AA001RNL | MFCD09864182
Submit
© 2017 AA BLOCKS, INC. All rights reserved.