Catalog No.:AA01EO5V

1575596-29-0 | PRN1008

Name: Name:PRN1008
Brand: AABLOCKS
SKU: AA01EO5V
Rating: 90 (10 reviews)

Pack Size

Purity

Availability

Price(USD)

Quantity

5mg

95%

in stock

$598.00 $419.00

- +

10mg

95%

in stock

$912.00 $639.00

- +

25mg

95%

in stock

$1,797.00 $1,258.00

- +

Technical Information
Properties
Literature
Request for Quotation
Download SDS

Technical Information

Catalog Number:

AA01EO5V

Chemical Name:

PRN1008

CAS Number:

1575596-29-0

Molecular Formula:

C36H40FN9O3

Molecular Weight:

665.7597

MDL Number:

MFCD31631583

SMILES:

N#C/C(=C\C(N1CCN(CC1)C1COC1)(C)C)/C(=O)N1CCC[C@H](C1)n1nc(c2c1ncnc2N)c1ccc(cc1F)Oc1ccccc1

Properties

Computed Properties

Complexity:

1230

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Rotatable Bond Count:

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

3.4

Literature

Title: Smith PF, et al. A phase I trial of PRN1008, a novel reversible covalent inhibitor of Bruton's tyrosine kinase, in healthy volunteers. Br J Clin Pharmacol. 2017 Nov;83(11):2367-2376.

Title: Hill RJ, Bradshaw JM, Bisconte A, Tam D, Owens TD, Brameld KA, Smith PF, Funk JO, Goldstein DM, Nunn PA. Preclinical Characterization of PRN1008, a Novel Reversible Covalent Inhibitor of BTK that Shows Efficacy in a RAT Model of Collagen-Induced Arthritis. Annals of the Rheumatic Diseases 2015; 74(Suppl 2): 216.

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Tags:1575596-29-0 Molecular Formula|1575596-29-0 MDL|1575596-29-0 SMILES|1575596-29-0 PRN1008

Catalog No.: AA01EO5V

1575596-29-0 | PRN1008

Pack Size： 5mg

Purity： 95%

in stock

$598.00 $419.00

Pack Size： 10mg

Purity： 95%

in stock

$912.00 $639.00

Pack Size： 25mg

Purity： 95%

in stock

$1,797.00 $1,258.00

Quantity

- +

Add to Card

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bulk Quotation Request

Technical Information

Catalog Number: AA01EO5V

Chemical Name: PRN1008

CAS Number: 1575596-29-0

Molecular Formula: C36H40FN9O3

Molecular Weight: 665.7597

MDL Number: MFCD31631583

SMILES: N#C/C(=C\C(N1CCN(CC1)C1COC1)(C)C)/C(=O)N1CCC[C@H](C1)n1nc(c2c1ncnc2N)c1ccc(cc1F)Oc1ccccc1

Properties

Complexity: 1230

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 1

Formal Charge: 0

Heavy Atom Count: 49

Hydrogen Bond Acceptor Count: 11

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 8

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.4

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