Name: Name:Phosphonic acid, P-[[3,4-dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-
Brand: AABLOCKS
SKU: AA001VNZ
Rating: 90 (10 reviews)

Catalog No.: AA001VNZ

161605-73-8 | Phosphonic acid, P-[[3,4-dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-

Pack Size： 5mg

Purity： 99%

1 week

$222.00 $155.00

Pack Size： 10mg

Purity： 99%

1 week

$317.00 $222.00

Pack Size： 50mg

Purity： 99%

1 week

$1,177.00 $824.00

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Technical Information

Catalog Number: AA001VNZ

Chemical Name: Phosphonic acid, P-[[3,4-dihydro-7-(4-morpholinyl)-2,3-dioxo-6-(trifluoromethyl)-1(2H)-quinoxalinyl]methyl]-

CAS Number: 161605-73-8

Molecular Formula: C14H15F3N3O6P

Molecular Weight: 409.2544

MDL Number: MFCD07364000

SMILES: O=c1[nH]c2cc(c(cc2n(c1=O)CP(=O)(O)O)N1CCOCC1)C(F)(F)F

Properties

Storage: Inert atmosphere;2-8℃;

Complexity: 651

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 27

Hydrogen Bond Acceptor Count: 10

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: -0.5

Downstream Synthesis Route

Literature fold

Title: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.

Journal: Journal of medicinal chemistry20100812

Title: Effects of the AMPA antagonist ZK 200775 on visual function: a randomized controlled trial.

Journal: PloS one20100101

Title: Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat.

Journal: Neuroscience20081028

Title: Nicotine-induced dopamine release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551.

Journal: Psychopharmacology20040801

Title: AMPA antagonist ZK200775 in patients with acute ischemic stroke: possible glial cell toxicity detected by monitoring of S-100B serum levels.

Journal: Stroke20021201

Title: Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.

Journal: Bioorganic & medicinal chemistry letters20010507

Title: Turski L, et al. ZK200775: a phosphonate quinoxalinedione AMPA antagonist for neuroprotection in stroke and trauma. Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10960-5.

Title: Kosowski AR, et al. Nicotine-induced dopamine release in the nucleus accumbens is inhibited by the novel AMPA antagonist ZK200775 and the NMDA antagonist CGP39551. Psychopharmacology (Berl). 2004 Aug;175(1):114-23.

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