Title: Neurogenic airway microvascular leakage induced by toluene inhalation in rats.
Journal: European journal of pharmacology 20120615
Title: In-silico characterization of ECE-1 inhibitors.
Journal: Computers in biology and medicine 20120401
Title: Antinociceptive effect of [Met5]enkephalin semicarbazide is not affected by dipeptidyl carboxypeptidase-I.
Journal: Journal of peptide science : an official publication of the European Peptide Society 20120201
Title: The role of neutral endopeptidase in caerulein-induced acute pancreatitis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20111115
Title: Aβ-degrading enzymes: potential for treatment of Alzheimer disease.
Journal: Journal of neuropathology and experimental neurology 20111101
Title: Crystal structure of Mycobacterium tuberculosis zinc-dependent metalloprotease-1 (Zmp1), a metalloprotease involved in pathogenicity.
Journal: The Journal of biological chemistry 20110916
Title: Dendroaspis natriuretic peptide and the designer natriuretic peptide, CD-NP, are resistant to proteolytic inactivation.
Journal: Journal of molecular and cellular cardiology 20110701
Title: Cysteine cathepsins in human carious dentin.
Journal: Journal of dental research 20110401
Title: Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice.
Journal: Journal of molecular neuroscience : MN 20110301
Title: Endothelin-1 expression by vascular endothelial growth factor in human umbilical vein endothelial cells and aortic smooth muscle cells.
Journal: Hypertension in pregnancy 20110101
Title: Neprilysin-2 is an important β-amyloid degrading enzyme.
Journal: The American journal of pathology 20110101
Title: Bradykinin-induced lung inflammation and bronchoconstriction: role in parainfluenze-3 virus-induced inflammation and airway hyperreactivity.
Journal: The Journal of pharmacology and experimental therapeutics 20101201
Title: Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries.
Journal: Circulation research 20100723
Title: Production of an antigenic peptide by insulin-degrading enzyme.
Journal: Nature immunology 20100501
Title: Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.
Journal: Peptides 20100201
Title: Positron emission tomography of [18F]-big endothelin-1 reveals renal excretion but tissue-specific conversion to [18F]-endothelin-1 in lung and liver.
Journal: British journal of pharmacology 20100201
Title: Intrathecal substance P augments morphine-induced antinociception: possible relevance in the production of substance P N-terminal fragments.
Journal: Peptides 20090901
Title: Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia.
Journal: Magnesium research 20090901
Title: Functional and molecular characterization of the endothelin system in retinal arterioles.
Journal: Investigative ophthalmology & visual science 20090701
Title: Structure of human endothelin-converting enzyme I complexed with phosphoramidon.
Journal: Journal of molecular biology 20090109
Title: [Changes in the activity of amyloid-degrading metallopeptidases leads to disruption of memory in rats].
Journal: Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20090101
Title: Role of endogenous endothelin-1 in post-ischemic cardiac dysfunction and norepinephrine overflow in rat hearts.
Journal: European journal of pharmacology 20080904
Title: Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2.
Journal: Journal of medicinal chemistry 20080626
Title: Phosphoramidon, an endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.
Journal: Experimental lung research 20080301
Title: Great increase in antinociceptive potency of [Leu5]enkephalin after peptidase inhibition.
Journal: Journal of pharmacological sciences 20080201
Title: Effects of endothelin-1 1-31 on cell viabililty and [Ca2+]i in cultured neonatal rat cardiomyocytes.
Journal: Physiological research 20080101
Title: Activation of the amyloid cascade by intracerebroventricular injection of the protease inhibitor phosphoramidon.
Journal: Neuro-degenerative diseases 20080101
Title: Metabolic inactivation of the circadian transmitter, pigment dispersing factor (PDF), by neprilysin-like peptidases in Drosophila.
Journal: The Journal of experimental biology 20071201
Title: Characterisation of endothelin converting enzyme-1 shedding from endothelial cells.
Journal: FEBS letters 20070918
Title: The enhancing effects of peptidase inhibitors on the antinociceptive action of [Met5]enkephalin-Arg6-Phe7 in rats.
Journal: Journal of pharmacological sciences 20070901
Title: Potentiation of bradykinin effect by angiotensin-converting enzyme inhibition does not correlate with angiotensin-converting enzyme activity in the rat mesenteric arteries.
Journal: Hypertension (Dallas, Tex. : 1979) 20070701
Title: Functional evidence of des-Arg10-kallidin enzymatic inactivating pathway in isolated human umbilical vein.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070501
Title: Antagonism of phosphoramidon-induced antinociception in mice by mu- but not kappa-opioid receptor blockers.
Journal: Life sciences 20070417
Title: Effect of chronic ethanol consumption on endothelin-1 generation and conversion of exogenous big-endothelin-1 by the rat carotid artery.
Journal: Alcohol (Fayetteville, N.Y.) 20070301
Title: Neutral endopeptidase up-regulation in isolated human umbilical artery: involvement in desensitization of bradykinin-induced vasoconstrictor effects.
Journal: The Journal of pharmacology and experimental therapeutics 20070201
Title: Expression of NEP2, a soluble neprilysin-like endopeptidase, during embryogenesis in Drosophila melanogaster.
Journal: Peptides 20070101
Title: Inhibition of neutral endopeptidase by thiorphan does not modify coronary vascular responses to angiotensin I, angiotensin II and bradykinin in the isolated guinea pig heart.
Journal: Pharmacological reports : PR 20070101
Title: Big ET-1 processing into vasoactive peptides in arteries and veins.
Journal: Vascular pharmacology 20070101
Title: Neprilysin protects human neuronal progenitor cells against impaired development caused by amyloid-beta peptide.
Journal: Brain research 20061208
Title: Preparation of a protected phosphoramidon precursor via an H-phosphonate coupling strategy.
Journal: Bioorganic & medicinal chemistry letters 20061101
Title: Effects of big endothelin-1 in comparison with endothelin-1 on the microvascular blood flow velocity and diameter of rat mesentery in vivo.
Journal: Microvascular research 20061101
Title: Arrhythmogenic action of endothelin-1(1-31) through conversion to endothelin-1(1-21).
Journal: Experimental biology and medicine (Maywood, N.J.) 20060601
Title: Angiotensin converting enzyme has an inhibitory role in CGRP metabolism in human skin.
Journal: Peptides 20060401
Title: Phosphodiesterase IV and neutral endopeptidase in airways from developing and allergen sensitized rabbits.
Journal: Pulmonary pharmacology & therapeutics 20060101
Title: Blood pressure responses of endothelin-1 1-31 within the rostral ventrolateral medulla through conversion to endothelin-1 1-21.
Journal: Journal of cardiovascular pharmacology 20051201
Title: Role of endothelin-1-dependent up-regulation of leptin in oral mucosal repair.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20051201
Title: Endothelin-1-dependent leptin induction in gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide.
Journal: Biochemical and biophysical research communications 20051104
Title: NEP inhibitors enhance C-type natriuretic peptide-induced relaxation in porcine isolated coronary artery.
Journal: Vascular pharmacology 20051001
Title: Inhibition of neutral endopeptidase (NEP) facilitates neurogenic inflammation.
Journal: Experimental neurology 20050901
Title: Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.
Journal: Hypertension (Dallas, Tex. : 1979) 20050701
Title: Contribution of endogenous endothelin-1 to basal vascular tone during normal pregnancy and preeclampsia.
Journal: American journal of obstetrics and gynecology 20050701
Title: The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs.
Journal: European journal of pharmacology 20050418
Title: Purification, characterization cloning, and sequencing of metalloendopeptidase from Streptomyces septatus TH-2.
Journal: Archives of biochemistry and biophysics 20050215
Title: Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.
Journal: Molecular pharmacology 20050101
Title: Effective antiprotease-antibiotic treatment of experimental anthrax.
Journal: BMC infectious diseases 20050101
Title: Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats.
Journal: Behavioural brain research 20041005
Title: Despite minimal hemodynamic alterations endotoxemia modulates NOS and p38-MAPK phosphorylation via metalloendopeptidases.
Journal: Molecular and cellular biochemistry 20041001
Title: [Physiological and pathophysiological roles of the endothelin converting enzymes].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040901
Title: Hypoxia augments TNF-alpha-mediated endothelin-1 release and cell proliferation in human optic nerve head astrocytes.
Journal: Biochemical and biophysical research communications 20040604
Title: Endothelin-induced constriction of the ductus venosus in fetal sheep: developmental aspects and possible interaction with vasodilatory prostaglandin.
Journal: British journal of pharmacology 20040601
Title: [Endothelin].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20040601
Title: A continuous spectrophotometric assay for Pseudomonas aeruginosa LasA protease (staphylolysin) using a two-stage enzymatic reaction.
Journal: Analytical biochemistry 20040515
Title: The effect of phosphoramidon on inflammation-mediated preterm delivery in a mouse model.
Journal: American journal of obstetrics and gynecology 20040201
Title: Signal pathway involved in increased expression of neutral endopeptidase 24.11 by gonadotropin releasing hormone in choriocarcinoma cells.
Journal: Placenta 20040101
Title: [The new class of drugs-- metalloprotease inhibitors -- in the treatment of heart failure].
Journal: Klinicheskaia meditsina 20040101
Title: A low dose of angiotensin II increases inotropism through activation of reverse Na(+)/Ca(2+) exchange by endothelin release.
Journal: Cardiovascular research 20031201
Title: [Protective effects of phosphoramidon on the experimental myocardial injury in rats].
Journal: Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20031201
Title: Active amino acids of the Kell blood group protein and model of the ectodomain based on the structure of neutral endopeptidase 24.11.
Journal: Blood 20031015
Title: Metalloendopeptidase inhibition regulates phosphorylation of p38-mitogen-activated protein kinase and nitric oxide synthase in heart after endotoxemia.
Journal: Shock (Augusta, Ga.) 20031001
Title: The role of endothelin converting enzyme inhibition during group B streptococcus-induced pulmonary hypertension in newborn piglets.
Journal: Pediatric research 20030901
Title: Cerebral angiogenesis and expression of VEGF after subarachnoid hemorrhage (SAH) in rats.
Journal: Brain research 20030815
Title: Isolation and characterization of a zinc-containing metalloprotease expressed by Vibrio tubiashii.
Journal: Canadian journal of microbiology 20030801
Title: The effects of phosphoramidon on the expression of human endothelin-converting enzyme-1 (ECE-1) isoforms.
Journal: Journal of cardiovascular pharmacology 20030701
Title: [D-Val22]big ET-1[16-38] inhibits endothelin-converting enzyme activity: a promising concept in the prevention of cerebral vasospasm.
Journal: Neurosurgical review 20030501
Title: Pseudomonas aeruginosa elastase degrades surfactant proteins A and D.
Journal: American journal of respiratory cell and molecular biology 20030401
Title: Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of protein kinase C constrictor pathway.
Journal: Neurological research 20030401
Title: Binding of a new bioactive 31-amino-acid endothelin-1 to an endothelin ET(B) or ET(B)-like receptor in porcine lungs.
Journal: European journal of pharmacology 20030328
Title: Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20030301
Title: Effects of kinins on mammalian spermatozoa and the impact of peptidolytic enzymes.
Journal: Andrologia 20030201
Title: Effect of endothelin-1 (1-31) on the renal resistance vessels.
Journal: The journal of medical investigation : JMI 20030201
Title: Role of tachykinins in the bronchoconstriction induced by HCl intraesophageal instillation in the rabbit.
Journal: Life sciences 20030124
Title: Action of three ectopeptidases on corticotropin-releasing factor: metabolism and functional aspects.
Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101
Title: Attenuation of renal ischemia/reperfusion injury by a triple drug combination therapy.
Journal: Journal of nephrology 20030101
Title: Cardioprotective effects of phosphoramidon on myocardial structure and function in murine Chagas' disease.
Journal: International journal for parasitology 20021101
Title: The mechanisms for tachykinin-induced contractions of the rabbit corpus cavernosum.
Journal: British journal of pharmacology 20021101
Title: Effect of endothelin-converting enzyme inhibitors on big endothelin-1 induced contraction in isolated rat basilar artery.
Journal: Acta neurochirurgica 20021101
Title: Combination therapy of N-acetylcysteine, sodium nitroprusside and phosphoramidon attenuates ischemia-reperfusion injury in rat kidney.
Journal: Molecular and cellular biochemistry 20021101
Title: Attenuation of ischemia/reperfusion induced MAP kinases by N-acetyl cysteine, sodium nitroprusside and phosphoramidon.
Journal: Molecular and cellular biochemistry 20021101
Title: The increased proliferation of cultured neuroblastoma cells treated with vasoactive intestinal peptide is enhanced by simultaneous inhibition of neutral endopeptidase.
Journal: Regulatory peptides 20021015
Title: Effect of quercetin on plasma extravasation in rat CNS and dura mater by ACE and NEP inhibition.
Journal: Phytotherapy research : PTR 20020901
Title: Endothelin-converting enzyme activity in human cerebral circulation.
Journal: Neurosurgery 20020801
Title: Characterization of PgPepO, a bacterial homologue of endothelin-converting enzyme-1.
Journal: Clinical science (London, England : 1979) 20020801
Title: Expression, purification and characterization of the monomeric and dimeric forms of soluble bovine endothelin converting enzyme-1a.
Journal: Clinical science (London, England : 1979) 20020801
Title: Phosphoramidon treatment improves the consequences of chagasic heart disease in mice.
Journal: Clinical science (London, England : 1979) 20020801
Title: Pressor and pulmonary responses to ET-1(1-31) in guinea-pigs.
Journal: British journal of pharmacology 20020701
Title: Possible involvement of placental peptidases that degrade gonadotropin-releasing hormone (GnRH) in the dynamic pattern of placental hCG secretion via GnRH degradation.
Journal: Placenta 20020701
Title: Vasospasm following subarachnoid hemorrhage: evidence against functional upregulation of Rho kinase constrictor pathway.
Journal: Neurological research 20020601
Title: Inhibition of endothelin-1 improves survival and vasculopathy in rat cardiac transplants treated with cyclosporine.
Journal: Transplantation 20020415
Title: Substance P induced preprotachykinin-a mRNA, neutral endopeptidase mRNA and substance P in cultured normal fibroblasts.
Journal: International archives of allergy and immunology 20020401
Title: Enhancement of neurokinin A-induced smooth muscle contraction in human urinary bladder by mucosal removal and phosphoramidon: relationship to peptidase inhibition.
Journal: European journal of pharmacology 20020308
Title: Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth.
Journal: The Journal of clinical endocrinology and metabolism 20020101
Title: Endothelin-converting enzyme activity in vascular smooth muscle preparations in vitro.
Journal: Methods in molecular biology (Clifton, N.J.) 20020101
Title: Zinc and Manduca sexta hemocyte functions.
Journal: Journal of insect science (Online) 20020101
Title: Soluble recombinant neprilysin induces aggrecanase-mediated cleavage of aggrecan in cartilage explant cultures.
Journal: Archives of biochemistry and biophysics 20011215
Title: The role of substance P release in the lung with esophageal acid.
Journal: The American journal of medicine 20011203
Title: Effect of neutral endopeptidase inhibitor on bradykinin-induced bronchoconstriction.
Journal: Life sciences 20011121
Title: In vitro contractile effects of neurokinin receptor blockade in the human ureter.
Journal: The Journal of urology 20011001
Title: Differential effects of U46619 on renal regional hemodynamics in the rat: involvement of endothelin.
Journal: The Journal of pharmacology and experimental therapeutics 20011001
Title: Determination of bradykinin in rat urine by coupled-column high pressure liquid chromatography with precolumn derivatization with a water-soluble fluorogenic reagent.
Journal: Analytical biochemistry 20011001
Title: Roles of mast cells and sensory nerves in cutaneous vascular hyperpermeability and scratching behavior induced by poly-L-arginine in rats.
Journal: European journal of pharmacology 20010817
Title: A proteinase inhibitor decreases tumor growth in a laparoscopic rat model.
Journal: Surgical endoscopy 20010801
Title: Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.
Journal: American journal of physiology. Gastrointestinal and liver physiology 20010801
Title: Changes in the expression of tachykinin receptors in the rat uterus during the course of pregnancy.
Journal: Biology of reproduction 20010801
Title: Degradation of the Alzheimer's amyloid beta peptide by endothelin-converting enzyme.
Journal: The Journal of biological chemistry 20010706
Title: Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan- and phosphoramidon-sensitive endopeptidases.
Journal: The Journal of biological chemistry 20010615
Title: Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid.
Journal: Oncogene 20010607
Title: Effect of ECE and NEP inhibition on cigarette smoke-induced cell proliferation in the rat lung.
Journal: Inhalation toxicology 20010601
Title: Endothelium-dependent relaxation in response to low concentrations of bradykinin is enhanced by phosphoramidon, bosentan and BQ-123 in bovine coronary arteries in vitro.
Journal: Japanese journal of pharmacology 20010601
Title: The lungs as an anti-inflammatory organ of the body.
Journal: Critical care medicine 20010501
Title: A three-dimensional model of endothelin-converting enzyme (ECE) based on the X-ray structure of neutral endopeptidase 24.11 (NEP).
Journal: Protein engineering 20010501
Title: Isoprostaglandin E2 type-III (8-iso-prostaglandin E2) evoked contractions in the human internal mammary artery.
Journal: Life sciences 20010413
Title: Phosphoramidon-sensitive endothelin-converting enzymes modulate cerebral blood flow and neural damage of hypoxic rats.
Journal: Neuroscience letters 20010330
Title: Reverse mode of the Na+-Ca2+ exchange after myocardial stretch: underlying mechanism of the slow force response.
Journal: Circulation research 20010302
Title: Interactions of human matrix metalloproteinase 7 (matrilysin) with the inhibitors thiorphan and R-94138.
Journal: Journal of biochemistry 20010301
Title: Antinociceptive effect produced by intracerebroventricularly administered dynorphin A is potentiated by p-hydroxymercuribenzoate or phosphoramidon in the mouse formalin test.
Journal: Brain research 20010209
Title: Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20010115
Title: Mitogen-activated protein kinase activity regulation role of angiotensin and endothelin systems in vascular smooth muscle cells.
Journal: European journal of pharmacology 20010105
Title: Effect of phosphoramidon on brain tissue angiogenesis in the chronic phase of vasospasm after subarachnoid hemorrhage in the rat.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101
Title: Role of endothelin-converting enzyme-1 in the suppression of constitutive nitric oxide synthase in rat gastric mucosal injury by indomethacin.
Journal: Scandinavian journal of gastroenterology 20001101
Title: Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme.
Journal: Japanese journal of pharmacology 20000901
Title: Morphine preconditioning attenuates neutrophil activation in rat models of myocardial infarction.
Journal: Cardiovascular research 19981201
Title: Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 19961101
Title: In vitro metabolism of an insect neuropeptide by neural membrane preparations from Lymantria dispar.
Journal: Peptides 19960101
Title: Regulation of N-formyl-methionyl-leucyl-phenylalanine receptor recycling by surface membrane neutral endopeptidase-mediated degradation of ligand.
Journal: Journal of leukocyte biology 19951001
Title: Brain cathepsin B but not metalloendopeptidases degrade rAPP751 with production of amyloidogenic fragments. Comparison with synthetic peptides emulating beta- and gamma-secretase sites.
Journal: International journal of peptide and protein research 19950101
Title: Purification and characterization of a neutral zinc endopeptidase secreted by Flavobacterium meningosepticum.
Journal: Archives of biochemistry and biophysics 19940515
Title: Degradation of bradykinin by neutral endopeptidase (EC 3.4.24.11) in cultured human endothelial cells.
Journal: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies 19930501
Title: Jurkat T cells express a functional neutral endopeptidase activity (CALLA) involved in T cell activation.
Journal: The EMBO journal 19921101
Title: Functional reactivity of different central opioid receptor systems following clomipramine treatments.
Journal: Pharmacological research 19900101
Title: Neuropeptide-degrading endopeptidase activity of locust (Schistocerca gregaria) synaptic membranes.
Journal: The Biochemical journal 19881101
Title: Effects of bestatin and phosphoramidon on the hypertensive response to physostigmine in the rat.
Journal: Fundamental & clinical pharmacology 19870101
Title: Enkephalinase inhibition suppresses naloxone-induced jumping in morphine-dependent mice.
Journal: Archives internationales de pharmacodynamie et de therapie 19861001
Title: Kukkola PJ, et al. Differential structure-activity relationships of phosphoramidon analogues for inhibition of three metalloproteases: endothelin-converting enzyme, neutral endopeptidase, and angiotensin-converting enzyme.J CardiovascPharmacol. 1995;26Suppl 3:S65-8.
Title: Sun Q, et al. Synthesis and enzymatic evaluation of phosphoramidon and its β anomer: Anomerization of α-l-rhamnose triacetate upon phosphitylation.Bioorg Med Chem. 2013 Nov 1;21(21):6778-87.
Title: Hanson LR, et al. Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice.J MolNeurosci. 2011 Mar;43(3):424-7.
Title: Bhavsar TM, et al. Phosphoramidon, an endothelin-converting enzyme inhibitor, attenuates lipopolysaccharide-induced acute lung injury.Exp Lung Res. 2008 Mar;34(3):141-54.
Title: Matsumaru K, et al. Phosphoramidon, an inhibitor of endothelin-converting enzyme, prevents indomethacin-induced gastric mucosal damage in rats.Life Sci. 1998;62(7):PL79-84.