16502-01-5,MFCD00004954
Catalog No.:AA001V5E

16502-01-5 | 1,2,3,4-Tetrahydro-9h-pyrido[3,4-b]indole

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Purity
Availability
Price(USD)
Quantity
  
250mg
95%
in stock  
$9.00   $7.00
- +
1g
97%
in stock  
$14.00   $10.00
- +
5g
97%
in stock  
$24.00   $17.00
- +
10g
97%
in stock  
$39.00   $27.00
- +
25g
97%
in stock  
$95.00   $67.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA001V5E
Chemical Name:
1,2,3,4-Tetrahydro-9h-pyrido[3,4-b]indole
CAS Number:
16502-01-5
Molecular Formula:
C11H12N2
Molecular Weight:
172.2264
MDL Number:
MFCD00004954
SMILES:
N1CCc2c(C1)[nH]c1c2cccc1
Properties
Computed Properties
 
Complexity:
193  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
1.5  

Literature

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease.

Journal: Molecules (Basel, Switzerland) 20120710

Title: Prospective acetylcholinesterase inhibitory activity of indole and its analogs.

Journal: Bioorganic & medicinal chemistry letters 20120415

Title: Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet-Spengler theme.

Journal: Chemical communications (Cambridge, England) 20120404

Title: Scaffold tailoring by a newly detected Pictet-Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework.

Journal: Journal of the American Chemical Society 20120125

Title: A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.

Journal: European journal of medicinal chemistry 20110801

Title: Dopamine acts as a partial agonist for α2A adrenoceptor in melanin-concentrating hormone neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110720

Title: Traceless synthesis of diketopiperazine fused tetrahydro-β-carbolines on soluble polymer support.

Journal: Molecular diversity 20110501

Title: Easy access to fully functionalized chiral tetrahydro-β-carboline alkaloids.

Journal: The Journal of organic chemistry 20110415

Title: Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

Journal: Archiv der Pharmazie 20110301

Title: Effects of spider venom toxin PWTX-I (6-Hydroxytrypargine) on the central nervous system of rats.

Journal: Toxins 20110201

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences 20110101

Title: Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.

Journal: PloS one 20110101

Title: Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

Journal: PloS one 20110101

Title: Interaction of β-carboline alkaloids with RNA.

Journal: DNA and cell biology 20101201

Title: Triazolyl tryptoline derivatives as β-secretase inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20101115

Title: Beta-carboline alkaloids bind DNA.

Journal: Journal of photochemistry and photobiology. B, Biology 20100802

Title: Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.

Journal: Bioorganic & medicinal chemistry 20100615

Title: Profiling of residue-level photo-oxidative damage in peptides.

Journal: Amino acids 20100601

Title: Direct and selective functionalization of a tetrahydro-beta-carboline at position 4.

Journal: Organic letters 20100319

Title: Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage.

Journal: International journal of molecular sciences 20100101

Title: Pictet-Spengler reactions for the synthesis of pharmaceutically relevant heterocycles.

Journal: Current opinion in drug discovery & development 20100101

Title: Traceless synthesis of hydantoin fused tetrahydro-beta-carboline on ionic liquid support in green media.

Journal: Organic letters 20091105

Title: Monoamine oxidase inhibitory activities of indolylalkaloid toxins from the venom of the colonial spider Parawixia bistriata: functional characterization of PwTX-I.

Journal: Toxicon : official journal of the International Society on Toxinology 20091101

Title: Alterations of nocturnal activity in rats following subchronic oral administration of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20091001

Title: The Methyltetrahydro-{beta}-Carbolines in Maca (Lepidium meyenii).

Journal: Evidence-based complementary and alternative medicine : eCAM 20090901

Title: Molecular determinants of beta-carboline inhibition of the glycine receptor.

Journal: Journal of neurochemistry 20090901

Title: Metaplasticity of hypothalamic synapses following in vivo challenge.

Journal: Neuron 20090625

Title: DMD mediated formal synthesis of (+/-)-coerulescine.

Journal: Natural product communications 20090601

Title: Facile synthesis of 1,2,3,4-tetrahydro-beta-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization.

Journal: Organic letters 20090507

Title: Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry.

Journal: European journal of medicinal chemistry 20090401

Title: Solution-phase parallel annulation of (thio)hydantoins to tetrahydroisoquinolines and tetrahydro-beta-carbolines containing the 2-arylethyl amine scaffold.

Journal: Journal of combinatorial chemistry 20090101

Title: Synthesis of tetrahydro-beta-carbolines and tetrahydroisoquinolines fused to pyrrolidines and solution-phase parallel acylation.

Journal: Journal of combinatorial chemistry 20090101

Title: Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.

Journal: Journal of chromatography. A 20081107

Title: Syntheses of tetrahydro-beta-carbolines via a tandem hydroformylation-Pictet-Spengler reaction. Scope and limitations.

Journal: Organic & biomolecular chemistry 20081107

Title: Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure.

Journal: Neuroscience 20081028

Title: A novel access to tetrahydro-beta-carbolines via one-pot hydroformylation/fischer indole synthesis: rearrangement of 3,3-spiroindoleninium cations.

Journal: Organic letters 20080821

Title: [Synthesis and biological evaluation of tetrahydro-beta-carline derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20080801

Title: A tetrahydro beta-carboline trisaccharide from Palicourea coriacea (Cham.) K. Schum.

Journal: Carbohydrate research 20080505

Title: Design, synthesis and cardioprotective effect of a new class of dual-acting agents: phenolic tetrahydro-beta-carboline RGD peptidomimetic conjugates.

Journal: Bioorganic & medicinal chemistry 20071115

Title: Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20061201

Title: Increased level of tetrahydro-beta-carboline derivatives in short-term fermented garlic.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20061201

Title: Solid-phase synthesis of tetrahydro-beta-carbolines and tetrahydroisoquinolines by stereoselective intramolecular N-carbamyliminium Pictet-Spengler reactions.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20061025

Title: Dual-acting agents that possess free radical scavenging and antithrombotic activities: design, synthesis, and evaluation of phenolic tetrahydro-beta-carboline RGD peptide conjugates.

Journal: Bioorganic & medicinal chemistry letters 20060901

Title: Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity.

Journal: Bioorganic & medicinal chemistry 20060715

Title: Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by beta-carboline alkaloids occurring in foods and plants.

Journal: Journal of chromatography. A 20060707

Title: Analytical characterisation of the routes by thermolytic decarboxylation from tryptophan to tryptamine using ketone catalysts, resulting in tetrahydro-beta-carboline formation.

Journal: Journal of pharmaceutical and biomedical analysis 20060607

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Development of the Pictet-Spengler reaction catalyzed by AuCl3/AgOTf.

Journal: The Journal of organic chemistry 20060317

Title: Highly enantioselective synthesis of tetrahydro-beta-carbolines and tetrahydro-gamma-carbolines via Pd-catalyzed intramolecular allylic alkylation.

Journal: Journal of the American Chemical Society 20060208

Title: Catalytic asymmetric Pictet-Spengler reaction.

Journal: Journal of the American Chemical Society 20060201

Title: Sinoaortic denervation abolishes blood pressure-induced GABA release in the locus coeruleus of conscious rats.

Journal: Neuroscience letters 20060130

Title: Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Journal: Bioorganic & medicinal chemistry 20051115

Title: Antimalarial constituents from Nauclea orientalis (L.) L.

Journal: Chemistry & biodiversity 20051001

Title: High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.

Journal: European journal of pharmacology 20050822

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Structure determination of a tetrahydro-beta-carboline of arthropod origin: a novel alkaloid-toxin subclass from the web of spider Nephila clavipes.

Journal: Chemistry & biodiversity 20050401

Title: Chiral ligands derived from Abrine 8. An experimental and theoretical study of free ligand conformational preferences and the addition of diethylzinc to benzaldehyde.

Journal: The Journal of organic chemistry 20050107

Title: Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats.

Journal: Journal of neurophysiology 20050101

Title: Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis.

Journal: Journal of the neurological sciences 20041015

Title: Identification and occurrence of tryptamine- and tryptophan-derived tetrahydro-beta-carbolines in commercial sausages.

Journal: Journal of agricultural and food chemistry 20040505

Title: High-performance liquid chromatographic analysis of beta-carbolines in human scalp hair.

Journal: Journal of chromatography. A 20040326

Title: The emergence of selective 5-HT 2B antagonists structures, activities and potential therapeutic applications.

Journal: Mini reviews in medicinal chemistry 20040301

Title: Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay.

Journal: Free radical research 20040301

Title: Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.

Journal: Bioorganic & medicinal chemistry letters 20040223

Title: Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.

Journal: Bioorganic & medicinal chemistry letters 20040223

Title: Binding of an imidazopyridoindole at imidazoline I2 receptors.

Journal: Bioorganic & medicinal chemistry letters 20040119

Title: Selective scavenging property of the indole moiety for the nitrating species of peroxynitrite.

Journal: Chemical & pharmaceutical bulletin 20040101

Title: A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction.

Journal: Molecular diversity 20040101

Title: Binding of beta-carbolines at 5-HT(2) serotonin receptors.

Journal: Bioorganic & medicinal chemistry letters 20031215

Title: Tetrahydro-beta-carboline alkaloids occur in fruits and fruit juices. Activity as antioxidants and radical scavengers.

Journal: Journal of agricultural and food chemistry 20031119

Title: Synthesis of bridged azabicyclic structures via ring-closing olefin metathesis.

Journal: The Journal of organic chemistry 20031114

Title: New versatile route to the synthesis of tetrahydro-beta-carbolines and tetrahydro-pyrano[3,4-b]indoles via an intramolecular Michael addition catalyzed by InBr3.

Journal: The Journal of organic chemistry 20030905

Title: Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.

Journal: Journal of medicinal chemistry 20030828

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry 20030703

Title: Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.

Journal: Pharmacogenetics 20030601

Title: L-tryptophan reacts with naturally occurring and food-occurring phenolic aldehydes to give phenolic tetrahydro-beta-carboline alkaloids: activity as antioxidants and free radical scavengers.

Journal: Journal of agricultural and food chemistry 20030409

Title: Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay.

Journal: Free radical research 20020801

Title: Identification and occurrence of the novel alkaloid pentahydroxypentyl-tetrahydro-beta-carboline-3-carboxylic acid as a tryptophan glycoconjugate in fruit juices and jams.

Journal: Journal of agricultural and food chemistry 20020731

Title: Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K.

Journal: Journal of natural products 20020401

Title: Application of a new chiral derivatizing agent to the enantioseparation of secondary amino acids.

Journal: Journal of chromatography. A 20020301

Title: Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract.

Journal: BioFactors (Oxford, England) 20020101

Title: Quantitative structure-activity relationship study on tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.

Journal: Journal of enzyme inhibition 20011201

Title: Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.

Journal: Journal of medicinal chemistry 20010830

Title: Reduction of rat brain levels of the endogenous dopaminergic proneurotoxins 1,2,3,4-tetrahydroisoquinoline and 1,2,3,4-tetrahydro-beta-carboline by cigarette smoke.

Journal: Neuroscience letters 20010209

Title: Behavioural and electrocortical power spectrum effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats.

Journal: European journal of pharmacology 19871006

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SDS
Tags:16502-01-5 Molecular Formula|16502-01-5 MDL|16502-01-5 SMILES|16502-01-5 1,2,3,4-Tetrahydro-9h-pyrido[3,4-b]indole
Catalog No.: AA001V5E
16502-01-5,MFCD00004954
16502-01-5 | 1,2,3,4-Tetrahydro-9h-pyrido[3,4-b]indole
Pack Size: 250mg
Purity: 95%
in stock
$9.00 $7.00
Pack Size: 1g
Purity: 97%
in stock
$14.00 $10.00
Pack Size: 5g
Purity: 97%
in stock
$24.00 $17.00
Pack Size: 10g
Purity: 97%
in stock
$39.00 $27.00
Pack Size: 25g
Purity: 97%
in stock
$95.00 $67.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA001V5E
Chemical Name: 1,2,3,4-Tetrahydro-9h-pyrido[3,4-b]indole
CAS Number: 16502-01-5
Molecular Formula: C11H12N2
Molecular Weight: 172.2264
MDL Number: MFCD00004954
SMILES: N1CCc2c(C1)[nH]c1c2cccc1
Properties
Complexity: 193  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 1  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 1.5  
Literature fold

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry20121115

Title: From BACE1 inhibitor to multifunctionality of tryptoline and tryptamine triazole derivatives for Alzheimer's disease.

Journal: Molecules (Basel, Switzerland)20120710

Title: Prospective acetylcholinesterase inhibitory activity of indole and its analogs.

Journal: Bioorganic & medicinal chemistry letters20120415

Title: Synthesis of tetrahydro-β-carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the Pictet-Spengler theme.

Journal: Chemical communications (Cambridge, England)20120404

Title: Scaffold tailoring by a newly detected Pictet-Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework.

Journal: Journal of the American Chemical Society20120125

Title: A class of oral N-[(1S,3S)-1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carbonyl]- N'-(amino-acid-acyl)hydrazine: discovery, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.

Journal: European journal of medicinal chemistry20110801

Title: Dopamine acts as a partial agonist for α2A adrenoceptor in melanin-concentrating hormone neurons.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110720

Title: Traceless synthesis of diketopiperazine fused tetrahydro-β-carbolines on soluble polymer support.

Journal: Molecular diversity20110501

Title: Easy access to fully functionalized chiral tetrahydro-β-carboline alkaloids.

Journal: The Journal of organic chemistry20110415

Title: Design, synthesis and structure-activity relationship of functionalized tetrahydro-β-carboline derivatives as novel PDE5 inhibitors.

Journal: Archiv der Pharmazie20110301

Title: Effects of spider venom toxin PWTX-I (6-Hydroxytrypargine) on the central nervous system of rats.

Journal: Toxins20110201

Title: The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.

Journal: International journal of molecular sciences20110101

Title: Expression and function of serotonin 2A and 2B receptors in the mammalian respiratory network.

Journal: PloS one20110101

Title: Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

Journal: PloS one20110101

Title: Interaction of β-carboline alkaloids with RNA.

Journal: DNA and cell biology20101201

Title: Triazolyl tryptoline derivatives as β-secretase inhibitors.

Journal: Bioorganic & medicinal chemistry letters20101115

Title: Beta-carboline alkaloids bind DNA.

Journal: Journal of photochemistry and photobiology. B, Biology20100802

Title: Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP.

Journal: Bioorganic & medicinal chemistry20100615

Title: Profiling of residue-level photo-oxidative damage in peptides.

Journal: Amino acids20100601

Title: Direct and selective functionalization of a tetrahydro-beta-carboline at position 4.

Journal: Organic letters20100319

Title: Melatonin and structurally-related compounds protect synaptosomal membranes from free radical damage.

Journal: International journal of molecular sciences20100101

Title: Pictet-Spengler reactions for the synthesis of pharmaceutically relevant heterocycles.

Journal: Current opinion in drug discovery & development20100101

Title: Traceless synthesis of hydantoin fused tetrahydro-beta-carboline on ionic liquid support in green media.

Journal: Organic letters20091105

Title: Monoamine oxidase inhibitory activities of indolylalkaloid toxins from the venom of the colonial spider Parawixia bistriata: functional characterization of PwTX-I.

Journal: Toxicon : official journal of the International Society on Toxinology20091101

Title: Alterations of nocturnal activity in rats following subchronic oral administration of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20091001

Title: The Methyltetrahydro-{beta}-Carbolines in Maca (Lepidium meyenii).

Journal: Evidence-based complementary and alternative medicine : eCAM20090901

Title: Molecular determinants of beta-carboline inhibition of the glycine receptor.

Journal: Journal of neurochemistry20090901

Title: Metaplasticity of hypothalamic synapses following in vivo challenge.

Journal: Neuron20090625

Title: DMD mediated formal synthesis of (+/-)-coerulescine.

Journal: Natural product communications20090601

Title: Facile synthesis of 1,2,3,4-tetrahydro-beta-carbolines by one-pot domino three-component indole formation and nucleophilic cyclization.

Journal: Organic letters20090507

Title: Comparative study of the trypanocidal activity of the methyl 1-nitrophenyl-1,2,3,4-9H-tetrahydro-beta-carboline-3-carboxylate derivatives and benznidazole using theoretical calculations and cyclic voltammetry.

Journal: European journal of medicinal chemistry20090401

Title: Solution-phase parallel annulation of (thio)hydantoins to tetrahydroisoquinolines and tetrahydro-beta-carbolines containing the 2-arylethyl amine scaffold.

Journal: Journal of combinatorial chemistry20090101

Title: Synthesis of tetrahydro-beta-carbolines and tetrahydroisoquinolines fused to pyrrolidines and solution-phase parallel acylation.

Journal: Journal of combinatorial chemistry20090101

Title: Fingerprint analysis of thermolytic decarboxylation of tryptophan to tryptamine catalyzed by natural oils.

Journal: Journal of chromatography. A20081107

Title: Syntheses of tetrahydro-beta-carbolines via a tandem hydroformylation-Pictet-Spengler reaction. Scope and limitations.

Journal: Organic & biomolecular chemistry20081107

Title: Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure.

Journal: Neuroscience20081028

Title: A novel access to tetrahydro-beta-carbolines via one-pot hydroformylation/fischer indole synthesis: rearrangement of 3,3-spiroindoleninium cations.

Journal: Organic letters20080821

Title: [Synthesis and biological evaluation of tetrahydro-beta-carline derivatives].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica20080801

Title: A tetrahydro beta-carboline trisaccharide from Palicourea coriacea (Cham.) K. Schum.

Journal: Carbohydrate research20080505

Title: Design, synthesis and cardioprotective effect of a new class of dual-acting agents: phenolic tetrahydro-beta-carboline RGD peptidomimetic conjugates.

Journal: Bioorganic & medicinal chemistry20071115

Title: Cytotoxicity of chloral-derived beta-carbolines is not specific towards neuronal nor dopaminergic cells.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20061201

Title: Increased level of tetrahydro-beta-carboline derivatives in short-term fermented garlic.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands)20061201

Title: Solid-phase synthesis of tetrahydro-beta-carbolines and tetrahydroisoquinolines by stereoselective intramolecular N-carbamyliminium Pictet-Spengler reactions.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany)20061025

Title: Dual-acting agents that possess free radical scavenging and antithrombotic activities: design, synthesis, and evaluation of phenolic tetrahydro-beta-carboline RGD peptide conjugates.

Journal: Bioorganic & medicinal chemistry letters20060901

Title: Synthesis of new class dipeptide analogues with improved permeability and antithrombotic activity.

Journal: Bioorganic & medicinal chemistry20060715

Title: Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by beta-carboline alkaloids occurring in foods and plants.

Journal: Journal of chromatography. A20060707

Title: Analytical characterisation of the routes by thermolytic decarboxylation from tryptophan to tryptamine using ketone catalysts, resulting in tetrahydro-beta-carboline formation.

Journal: Journal of pharmaceutical and biomedical analysis20060607

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Development of the Pictet-Spengler reaction catalyzed by AuCl3/AgOTf.

Journal: The Journal of organic chemistry20060317

Title: Highly enantioselective synthesis of tetrahydro-beta-carbolines and tetrahydro-gamma-carbolines via Pd-catalyzed intramolecular allylic alkylation.

Journal: Journal of the American Chemical Society20060208

Title: Catalytic asymmetric Pictet-Spengler reaction.

Journal: Journal of the American Chemical Society20060201

Title: Sinoaortic denervation abolishes blood pressure-induced GABA release in the locus coeruleus of conscious rats.

Journal: Neuroscience letters20060130

Title: Synthesis and biological evaluation of new tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin Eg5.

Journal: Bioorganic & medicinal chemistry20051115

Title: Antimalarial constituents from Nauclea orientalis (L.) L.

Journal: Chemistry & biodiversity20051001

Title: High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.

Journal: European journal of pharmacology20050822

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology20050601

Title: Structure determination of a tetrahydro-beta-carboline of arthropod origin: a novel alkaloid-toxin subclass from the web of spider Nephila clavipes.

Journal: Chemistry & biodiversity20050401

Title: Chiral ligands derived from Abrine 8. An experimental and theoretical study of free ligand conformational preferences and the addition of diethylzinc to benzaldehyde.

Journal: The Journal of organic chemistry20050107

Title: Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats.

Journal: Journal of neurophysiology20050101

Title: Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis.

Journal: Journal of the neurological sciences20041015

Title: Identification and occurrence of tryptamine- and tryptophan-derived tetrahydro-beta-carbolines in commercial sausages.

Journal: Journal of agricultural and food chemistry20040505

Title: High-performance liquid chromatographic analysis of beta-carbolines in human scalp hair.

Journal: Journal of chromatography. A20040326

Title: The emergence of selective 5-HT 2B antagonists structures, activities and potential therapeutic applications.

Journal: Mini reviews in medicinal chemistry20040301

Title: Endogenous and dietary indoles: a class of antioxidants and radical scavengers in the ABTS assay.

Journal: Free radical research20040301

Title: Binding of beta-carbolines at imidazoline I2 receptors: a structure-affinity investigation.

Journal: Bioorganic & medicinal chemistry letters20040223

Title: Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.

Journal: Bioorganic & medicinal chemistry letters20040223

Title: Binding of an imidazopyridoindole at imidazoline I2 receptors.

Journal: Bioorganic & medicinal chemistry letters20040119

Title: Selective scavenging property of the indole moiety for the nitrating species of peroxynitrite.

Journal: Chemical & pharmaceutical bulletin20040101

Title: A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction.

Journal: Molecular diversity20040101

Title: Binding of beta-carbolines at 5-HT(2) serotonin receptors.

Journal: Bioorganic & medicinal chemistry letters20031215

Title: Tetrahydro-beta-carboline alkaloids occur in fruits and fruit juices. Activity as antioxidants and radical scavengers.

Journal: Journal of agricultural and food chemistry20031119

Title: Synthesis of bridged azabicyclic structures via ring-closing olefin metathesis.

Journal: The Journal of organic chemistry20031114

Title: New versatile route to the synthesis of tetrahydro-beta-carbolines and tetrahydro-pyrano[3,4-b]indoles via an intramolecular Michael addition catalyzed by InBr3.

Journal: The Journal of organic chemistry20030905

Title: Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.

Journal: Journal of medicinal chemistry20030828

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry20030703

Title: Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase.

Journal: Pharmacogenetics20030601

Title: L-tryptophan reacts with naturally occurring and food-occurring phenolic aldehydes to give phenolic tetrahydro-beta-carboline alkaloids: activity as antioxidants and free radical scavengers.

Journal: Journal of agricultural and food chemistry20030409

Title: Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay.

Journal: Free radical research20020801

Title: Identification and occurrence of the novel alkaloid pentahydroxypentyl-tetrahydro-beta-carboline-3-carboxylic acid as a tryptophan glycoconjugate in fruit juices and jams.

Journal: Journal of agricultural and food chemistry20020731

Title: Haploscleridamine, a novel tryptamine-derived alkaloid from a sponge of the order haplosclerida: an inhibitor of cathepsin K.

Journal: Journal of natural products20020401

Title: Application of a new chiral derivatizing agent to the enantioseparation of secondary amino acids.

Journal: Journal of chromatography. A20020301

Title: Antioxidant effects of tetrahydro-beta-carboline derivatives identified in aged garlic extract.

Journal: BioFactors (Oxford, England)20020101

Title: Quantitative structure-activity relationship study on tetrahydro-beta-carboline antagonists of the serotonin 2B (5HT2B) contractile receptor in the rat stomach fundus.

Journal: Journal of enzyme inhibition20011201

Title: Identification of potent non-peptide somatostatin antagonists with sst(3) selectivity.

Journal: Journal of medicinal chemistry20010830

Title: Reduction of rat brain levels of the endogenous dopaminergic proneurotoxins 1,2,3,4-tetrahydroisoquinoline and 1,2,3,4-tetrahydro-beta-carboline by cigarette smoke.

Journal: Neuroscience letters20010209

Title: Behavioural and electrocortical power spectrum effects of 5-methoxytryptoline and other analogs after intraventricular administration in rats.

Journal: European journal of pharmacology19871006

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