170098-38-1,MFCD00927248
Catalog No.:AA00HZAH

170098-38-1 | Alvimopan dihydrate

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
98%
in stock  
$250.00   $175.00
- +
10mg
98%
in stock  
$340.00   $238.00
- +
50mg
98%
in stock  
$906.00   $634.00
- +
250mg
98%
in stock  
$3,875.00   $2,713.00
- +
1g
98%
in stock  
$13,800.00   $9,660.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00HZAH
Chemical Name:
Alvimopan dihydrate
CAS Number:
170098-38-1
Molecular Formula:
C25H36N2O6
Molecular Weight:
460.5631
MDL Number:
MFCD00927248
SMILES:
OC(=O)CNC(=O)[C@@H](Cc1ccccc1)CN1CC[C@@]([C@H](C1)C)(C)c1cccc(c1)O.O.O
Properties
Properties
 
Form:
Solid  
MP:
210-213℃  
Storage:
Keep in dry area;2-8℃;  

Computed Properties
 
Complexity:
606  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0  
Rotatable Bond Count:
8  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Alvimopan provides rapid gastrointestinal recovery without nasogastric tube decompression after radical cystectomy and urinary diversion.

Journal: The Canadian journal of urology 20120601

Title: Re: Alvimopan provides rapid gastrointestinal recovery without nasogastric tube decompression after radical cystectomy and urinary diversion.

Journal: The Canadian journal of urology 20120601

Title: A meta-analysis of the effectiveness of the opioid receptor antagonist alvimopan in reducing hospital length of stay and time to GI recovery in patients enrolled in a standardized accelerated recovery program after abdominal surgery.

Journal: Diseases of the colon and rectum 20120501

Title: Evaluation of clinical outcomes with alvimopan in clinical practice: a national matched-cohort study in patients undergoing bowel resection.

Journal: Annals of surgery 20120401

Title: Real world efficacy of alvimopan on elective bowel resection patients: an analysis of statistical versus clinical significance.

Journal: American journal of surgery 20120301

Title: Alternatives to prokinetics to move the pylorus and colon.

Journal: Current opinion in clinical nutrition and metabolic care 20120301

Title: Management of postoperative ileus.

Journal: Orthopedics 20120301

Title: Economic analysis of alvimopan for prevention and management of postoperative ileus.

Journal: Pharmacotherapy 20120201

Title: Alvimopan for acceleration of GI recovery after bowel resection.

Journal: Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses 20120101

Title: Introduction of alvimopan into an enhanced recovery protocol for colectomy offers benefit in open but not laparoscopic colectomy.

Journal: Journal of laparoendoscopic & advanced surgical techniques. Part A 20111201

Title: Does alvimopan enhance return of bowel function in laparoscopic right colectomy?

Journal: The American surgeon 20111101

Title: The effect of alvimopan on recovery after laparoscopic segmental colectomy.

Journal: Diseases of the colon and rectum 20110601

Title: A randomized, placebo-controlled phase 3 trial (Study SB-767905/013) of alvimopan for opioid-induced bowel dysfunction in patients with non-cancer pain.

Journal: The journal of pain : official journal of the American Pain Society 20110201

Title: A randomized, placebo-controlled phase 3 trial (Study SB-767905/012) of alvimopan for opioid-induced bowel dysfunction in patients with non-cancer pain.

Journal: The journal of pain : official journal of the American Pain Society 20110201

Title: Current concepts in the management of opioid-induced constipation: a perfect review with an imperfect concept.

Journal: Journal of opioid management 20110101

Title: Alvimopan addition to a standard perioperative recovery pathway.

Journal: JSLS : Journal of the Society of Laparoendoscopic Surgeons 20110101

Title: Alvimopan use in laparoscopic and open bowel resections: clinical results in a large community hospital system.

Journal: The Annals of pharmacotherapy 20101101

Title: Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis.

Journal: World journal of surgery 20100901

Title: The effects of a short course of antibiotics on alvimopan and metabolite pharmacokinetics.

Journal: Journal of clinical pharmacology 20100301

Title: Peripheral opioid antagonism.

Journal: Anaesthesia 20091201

Title: Pharmacologic options to prevent postoperative ileus.

Journal: The Annals of pharmacotherapy 20090901

Title: Comment on alvimopan guidelines.

Journal: Critical care medicine 20090901

Title: Economic analysis of alvimopan in North American Phase III efficacy trials.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090801

Title: Alvimopan for postoperative ileus.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090715

Title: Alvimopan for postoperative ileus: only one piece of the puzzle.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20090715

Title: Opioid receptors in the gastrointestinal tract.

Journal: Regulatory peptides 20090605

Title: Preventing paralytic ileus: can the anesthesiologist help.

Journal: Middle East journal of anaesthesiology 20090601

Title: Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.

Journal: Lancet (London, England) 20090404

Title: Pharmacological management of postoperative ileus.

Journal: Canadian journal of surgery. Journal canadien de chirurgie 20090401

Title: An overview of constipation and newer therapies.

Journal: The American journal of hospice & palliative care 20090101

Title: Alvimopan (Entereg) for postoperative ileus.

Journal: The Medical letter on drugs and therapeutics 20081201

Title: Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway.

Journal: Archives of surgery (Chicago, Ill. : 1960) 20081101

Title: [News from the cochrane library: mu opioid antagonists for opioid-induced bowel dysfunction].

Journal: Zeitschrift fur Gastroenterologie 20080901

Title: Alvimopan.

Journal: Nature reviews. Drug discovery 20080901

Title: Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study.

Journal: Alimentary pharmacology & therapeutics 20080801

Title: Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain.

Journal: Pain 20080715

Title: New drug to restore bowel function approved under new FDA rules.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080701

Title: Alvimopan hastens recovery from abdominal surgery.

Journal: Managed care (Langhorne, Pa.) 20080701

Title: Alvimopan and COX-2 inhibition reverse opioid and inflammatory components of postoperative ileus.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20080601

Title: Pharmacokinetics of alvimopan and its metabolite in healthy volunteers and patients in postoperative ileus trials.

Journal: Clinical pharmacology and therapeutics 20080501

Title: Mu-opioid antagonists for opioid-induced bowel dysfunction.

Journal: The Cochrane database of systematic reviews 20080416

Title: Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.

Journal: Bioorganic & medicinal chemistry letters 20080315

Title: The involvement of the mu-opioid receptor in gastrointestinal pathophysiology: therapeutic opportunities for antagonism at this receptor.

Journal: Pharmacology & therapeutics 20080101

Title: New therapies in the treatment of postoperative ileus after gastrointestinal surgery.

Journal: American journal of therapeutics 20080101

Title: Alvimopan.

Journal: Drugs 20080101

Title: New drugs: methylnaltrexone bromide, alvimopan, and rilonacept.

Journal: Journal of the American Pharmacists Association : JAPhA 20080101

Title: Alvimopan accelerates gastrointestinal recovery after bowel resection regardless of age, gender, race, or concomitant medication use.

Journal: Surgery 20071001

Title: Alvimopan: a peripherally acting mu-opioid receptor antagonist.

Journal: Drugs of today (Barcelona, Spain : 1998) 20070901

Title: Cancer-related constipation.

Journal: Current oncology reports 20070701

Title: Patterns of gastrointestinal recovery after bowel resection and total abdominal hysterectomy: pooled results from the placebo arms of alvimopan phase III North American clinical trials.

Journal: Journal of the American College of Surgeons 20070701

Title: Novel and alternative therapies for childhood constipation.

Journal: Current gastroenterology reports 20070601

Title: Moving ahead or falling behind?

Journal: Nature clinical practice. Gastroenterology & hepatology 20070601

Title: The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070501

Title: Postoperative ileus-related morbidity profile in patients treated with alvimopan after bowel resection.

Journal: Journal of the American College of Surgeons 20070401

Title: Alvimopan, for postoperative ileus following bowel resection: a pooled analysis of phase III studies.

Journal: Annals of surgery 20070301

Title: Pharmacologic management of postoperative ileus: the next chapter in GI surgery.

Journal: Annals of surgery 20070301

Title: Meta-analysis: Alvimopan vs. placebo in the treatment of post-operative ileus.

Journal: Alimentary pharmacology & therapeutics 20070101

Title: Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.

Journal: Journal of pain & palliative care pharmacotherapy 20070101

Title: Pain management research goes beyond the obvious.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20061201

Title: The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats.

Journal: Brain research 20060802

Title: A double-blind, randomized, placebo-controlled phase III study of the safety of alvimopan in patients who undergo simple total abdominal hysterectomy.

Journal: American journal of obstetrics and gynecology 20060801

Title: Use of novel prokinetic agents to facilitate return of gastrointestinal motility in adult critically ill patients.

Journal: Current opinion in critical care 20060801

Title: Peripherally acting mu-opioid-receptor antagonists and the connection between postoperative ileus and pain management: The anesthesiologist's view and beyond.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20060401

Title: The surgical team and outcomes management: focus on postoperative ileus.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20060401

Title: Current choices--good or bad--for the proactive management of postoperative ileus: A surgeon's view.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20060401

Title: Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study.

Journal: Surgical endoscopy 20060101

Title: Alvimopan: ADL 8-2698, ADL 82698, Entrareg, LY 246736.

Journal: Drugs in R&D 20060101

Title: [(3)H]Alvimopan binding to the micro opioid receptor: comparative binding kinetics of opioid antagonists.

Journal: European journal of pharmacology 20050927

Title: Alvimopan for the management of postoperative ileus.

Journal: The Annals of pharmacotherapy 20050901

Title: Effect of alvimopan and codeine on gastrointestinal transit: a randomized controlled study.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20050801

Title: Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery.

Journal: Diseases of the colon and rectum 20050601

Title: Molecule of the month. Alvimopan hydrate.

Journal: Drug news & perspectives 20050601

Title: Alvimopan, a selective peripherally acting mu-opioid antagonist.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20050401

Title: Alvimopan.

Journal: Expert opinion on investigational drugs 20050401

Title: Alvimopan: an oral, peripherally acting, mu-opioid receptor antagonist for the treatment of opioid-induced bowel dysfunction--a 21-day treatment-randomized clinical trial.

Journal: The journal of pain : official journal of the American Pain Society 20050301

Title: Peripheral opiate action on afferent fibres supplying the rat intestine.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20041001

Title: Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus.

Journal: Annals of surgery 20041001

Title: Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans.

Journal: Neuroscience letters 20040506

Title: Emerging techniques for postoperative analgesia in orthopedic surgery.

Journal: American journal of orthopedics (Belle Mead, N.J.) 20040501

Title: Postoperative ileus: etiologies and interventions.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20030301

Title: Alvimopan (Adolor/GlaxoSmithKline).

Journal: Current opinion in investigational drugs (London, England : 2000) 20021001

Title: Awakening the sleeping postsurgical abdomen.

Journal: Gastroenterology 20020401

Title: Use of selective opiate receptor inhibitors to prevent postoperative ileus.

Journal: Minerva anestesiologica 20020401

Title: Alvimopan* (ADL 8-2698) is a novel peripheral opioid antagonist.

Journal: American journal of surgery 20011101

Title: Selective postoperative inhibition of gastrointestinal opioid receptors.

Journal: The New England journal of medicine 20010927

Title: An opioid antagonist for postoperative ileus.

Journal: The New England journal of medicine 20010927

Title: ADL 8-2698, a trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesia.

Journal: Clinical pharmacology and therapeutics 20010101

Title: Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12.

Title: Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33(10):574-83.

Title: Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53.

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Tags:170098-38-1 Molecular Formula|170098-38-1 MDL|170098-38-1 SMILES|170098-38-1 Alvimopan dihydrate
Catalog No.: AA00HZAH
170098-38-1,MFCD00927248
170098-38-1 | Alvimopan dihydrate
Pack Size: 5mg
Purity: 98%
in stock
$250.00 $175.00
Pack Size: 10mg
Purity: 98%
in stock
$340.00 $238.00
Pack Size: 50mg
Purity: 98%
in stock
$906.00 $634.00
Pack Size: 250mg
Purity: 98%
in stock
$3,875.00 $2,713.00
Pack Size: 1g
Purity: 98%
in stock
$13,800.00 $9,660.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA00HZAH
Chemical Name: Alvimopan dihydrate
CAS Number: 170098-38-1
Molecular Formula: C25H36N2O6
Molecular Weight: 460.5631
MDL Number: MFCD00927248
SMILES: OC(=O)CNC(=O)[C@@H](Cc1ccccc1)CN1CC[C@@]([C@H](C1)C)(C)c1cccc(c1)O.O.O
Properties
Form: Solid  
MP: 210-213℃  
Storage: Keep in dry area;2-8℃;  
Complexity: 606  
Covalently-Bonded Unit Count: 3  
Defined Atom Stereocenter Count: 3  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 33  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 5  
Isotope Atom Count: 0  
Rotatable Bond Count: 8  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Alvimopan provides rapid gastrointestinal recovery without nasogastric tube decompression after radical cystectomy and urinary diversion.

Journal: The Canadian journal of urology20120601

Title: Re: Alvimopan provides rapid gastrointestinal recovery without nasogastric tube decompression after radical cystectomy and urinary diversion.

Journal: The Canadian journal of urology20120601

Title: A meta-analysis of the effectiveness of the opioid receptor antagonist alvimopan in reducing hospital length of stay and time to GI recovery in patients enrolled in a standardized accelerated recovery program after abdominal surgery.

Journal: Diseases of the colon and rectum20120501

Title: Evaluation of clinical outcomes with alvimopan in clinical practice: a national matched-cohort study in patients undergoing bowel resection.

Journal: Annals of surgery20120401

Title: Real world efficacy of alvimopan on elective bowel resection patients: an analysis of statistical versus clinical significance.

Journal: American journal of surgery20120301

Title: Alternatives to prokinetics to move the pylorus and colon.

Journal: Current opinion in clinical nutrition and metabolic care20120301

Title: Management of postoperative ileus.

Journal: Orthopedics20120301

Title: Economic analysis of alvimopan for prevention and management of postoperative ileus.

Journal: Pharmacotherapy20120201

Title: Alvimopan for acceleration of GI recovery after bowel resection.

Journal: Medsurg nursing : official journal of the Academy of Medical-Surgical Nurses20120101

Title: Introduction of alvimopan into an enhanced recovery protocol for colectomy offers benefit in open but not laparoscopic colectomy.

Journal: Journal of laparoendoscopic & advanced surgical techniques. Part A20111201

Title: Does alvimopan enhance return of bowel function in laparoscopic right colectomy?

Journal: The American surgeon20111101

Title: The effect of alvimopan on recovery after laparoscopic segmental colectomy.

Journal: Diseases of the colon and rectum20110601

Title: A randomized, placebo-controlled phase 3 trial (Study SB-767905/013) of alvimopan for opioid-induced bowel dysfunction in patients with non-cancer pain.

Journal: The journal of pain : official journal of the American Pain Society20110201

Title: A randomized, placebo-controlled phase 3 trial (Study SB-767905/012) of alvimopan for opioid-induced bowel dysfunction in patients with non-cancer pain.

Journal: The journal of pain : official journal of the American Pain Society20110201

Title: Current concepts in the management of opioid-induced constipation: a perfect review with an imperfect concept.

Journal: Journal of opioid management20110101

Title: Alvimopan addition to a standard perioperative recovery pathway.

Journal: JSLS : Journal of the Society of Laparoendoscopic Surgeons20110101

Title: Alvimopan use in laparoscopic and open bowel resections: clinical results in a large community hospital system.

Journal: The Annals of pharmacotherapy20101101

Title: Alvimopan for the management of postoperative ileus after bowel resection: characterization of clinical benefit by pooled responder analysis.

Journal: World journal of surgery20100901

Title: The effects of a short course of antibiotics on alvimopan and metabolite pharmacokinetics.

Journal: Journal of clinical pharmacology20100301

Title: Peripheral opioid antagonism.

Journal: Anaesthesia20091201

Title: Pharmacologic options to prevent postoperative ileus.

Journal: The Annals of pharmacotherapy20090901

Title: Comment on alvimopan guidelines.

Journal: Critical care medicine20090901

Title: Economic analysis of alvimopan in North American Phase III efficacy trials.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20090801

Title: Alvimopan for postoperative ileus.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20090715

Title: Alvimopan for postoperative ileus: only one piece of the puzzle.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20090715

Title: Opioid receptors in the gastrointestinal tract.

Journal: Regulatory peptides20090605

Title: Preventing paralytic ileus: can the anesthesiologist help.

Journal: Middle East journal of anaesthesiology20090601

Title: Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.

Journal: Lancet (London, England)20090404

Title: Pharmacological management of postoperative ileus.

Journal: Canadian journal of surgery. Journal canadien de chirurgie20090401

Title: An overview of constipation and newer therapies.

Journal: The American journal of hospice & palliative care20090101

Title: Alvimopan (Entereg) for postoperative ileus.

Journal: The Medical letter on drugs and therapeutics20081201

Title: Gastrointestinal tract recovery in patients undergoing bowel resection: results of a randomized trial of alvimopan and placebo with a standardized accelerated postoperative care pathway.

Journal: Archives of surgery (Chicago, Ill. : 1960)20081101

Title: [News from the cochrane library: mu opioid antagonists for opioid-induced bowel dysfunction].

Journal: Zeitschrift fur Gastroenterologie20080901

Title: Alvimopan.

Journal: Nature reviews. Drug discovery20080901

Title: Clinical trial: alvimopan for the management of post-operative ileus after abdominal surgery: results of an international randomized, double-blind, multicentre, placebo-controlled clinical study.

Journal: Alimentary pharmacology & therapeutics20080801

Title: Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain.

Journal: Pain20080715

Title: New drug to restore bowel function approved under new FDA rules.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20080701

Title: Alvimopan hastens recovery from abdominal surgery.

Journal: Managed care (Langhorne, Pa.)20080701

Title: Alvimopan and COX-2 inhibition reverse opioid and inflammatory components of postoperative ileus.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20080601

Title: Pharmacokinetics of alvimopan and its metabolite in healthy volunteers and patients in postoperative ileus trials.

Journal: Clinical pharmacology and therapeutics20080501

Title: Mu-opioid antagonists for opioid-induced bowel dysfunction.

Journal: The Cochrane database of systematic reviews20080416

Title: Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles.

Journal: Bioorganic & medicinal chemistry letters20080315

Title: The involvement of the mu-opioid receptor in gastrointestinal pathophysiology: therapeutic opportunities for antagonism at this receptor.

Journal: Pharmacology & therapeutics20080101

Title: New therapies in the treatment of postoperative ileus after gastrointestinal surgery.

Journal: American journal of therapeutics20080101

Title: Alvimopan.

Journal: Drugs20080101

Title: New drugs: methylnaltrexone bromide, alvimopan, and rilonacept.

Journal: Journal of the American Pharmacists Association : JAPhA20080101

Title: Alvimopan accelerates gastrointestinal recovery after bowel resection regardless of age, gender, race, or concomitant medication use.

Journal: Surgery20071001

Title: Alvimopan: a peripherally acting mu-opioid receptor antagonist.

Journal: Drugs of today (Barcelona, Spain : 1998)20070901

Title: Cancer-related constipation.

Journal: Current oncology reports20070701

Title: Patterns of gastrointestinal recovery after bowel resection and total abdominal hysterectomy: pooled results from the placebo arms of alvimopan phase III North American clinical trials.

Journal: Journal of the American College of Surgeons20070701

Title: Novel and alternative therapies for childhood constipation.

Journal: Current gastroenterology reports20070601

Title: Moving ahead or falling behind?

Journal: Nature clinical practice. Gastroenterology & hepatology20070601

Title: The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone.

Journal: Naunyn-Schmiedeberg's archives of pharmacology20070501

Title: Postoperative ileus-related morbidity profile in patients treated with alvimopan after bowel resection.

Journal: Journal of the American College of Surgeons20070401

Title: Alvimopan, for postoperative ileus following bowel resection: a pooled analysis of phase III studies.

Journal: Annals of surgery20070301

Title: Pharmacologic management of postoperative ileus: the next chapter in GI surgery.

Journal: Annals of surgery20070301

Title: Meta-analysis: Alvimopan vs. placebo in the treatment of post-operative ileus.

Journal: Alimentary pharmacology & therapeutics20070101

Title: Novel opioid antagonists for opioid-induced bowel dysfunction and postoperative ileus.

Journal: Journal of pain & palliative care pharmacotherapy20070101

Title: Pain management research goes beyond the obvious.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists20061201

Title: The selective mu opioid receptor antagonist, alvimopan, improves delayed GI transit of postoperative ileus in rats.

Journal: Brain research20060802

Title: A double-blind, randomized, placebo-controlled phase III study of the safety of alvimopan in patients who undergo simple total abdominal hysterectomy.

Journal: American journal of obstetrics and gynecology20060801

Title: Use of novel prokinetic agents to facilitate return of gastrointestinal motility in adult critically ill patients.

Journal: Current opinion in critical care20060801

Title: Peripherally acting mu-opioid-receptor antagonists and the connection between postoperative ileus and pain management: The anesthesiologist's view and beyond.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses20060401

Title: The surgical team and outcomes management: focus on postoperative ileus.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses20060401

Title: Current choices--good or bad--for the proactive management of postoperative ileus: A surgeon's view.

Journal: Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses20060401

Title: Alvimopan, a peripherally acting mu-opioid receptor antagonist, compared with placebo in postoperative ileus after major abdominal surgery: results of a randomized, double-blind, controlled study.

Journal: Surgical endoscopy20060101

Title: Alvimopan: ADL 8-2698, ADL 82698, Entrareg, LY 246736.

Journal: Drugs in R&D20060101

Title: [(3)H]Alvimopan binding to the micro opioid receptor: comparative binding kinetics of opioid antagonists.

Journal: European journal of pharmacology20050927

Title: Alvimopan for the management of postoperative ileus.

Journal: The Annals of pharmacotherapy20050901

Title: Effect of alvimopan and codeine on gastrointestinal transit: a randomized controlled study.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association20050801

Title: Phase III trial of alvimopan, a novel, peripherally acting, mu opioid antagonist, for postoperative ileus after major abdominal surgery.

Journal: Diseases of the colon and rectum20050601

Title: Molecule of the month. Alvimopan hydrate.

Journal: Drug news & perspectives20050601

Title: Alvimopan, a selective peripherally acting mu-opioid antagonist.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20050401

Title: Alvimopan.

Journal: Expert opinion on investigational drugs20050401

Title: Alvimopan: an oral, peripherally acting, mu-opioid receptor antagonist for the treatment of opioid-induced bowel dysfunction--a 21-day treatment-randomized clinical trial.

Journal: The journal of pain : official journal of the American Pain Society20050301

Title: Peripheral opiate action on afferent fibres supplying the rat intestine.

Journal: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society20041001

Title: Alvimopan, a novel, peripherally acting mu opioid antagonist: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial of major abdominal surgery and postoperative ileus.

Journal: Annals of surgery20041001

Title: Opioids and opioid receptors in the enteric nervous system: from a problem in opioid analgesia to a possible new prokinetic therapy in humans.

Journal: Neuroscience letters20040506

Title: Emerging techniques for postoperative analgesia in orthopedic surgery.

Journal: American journal of orthopedics (Belle Mead, N.J.)20040501

Title: Postoperative ileus: etiologies and interventions.

Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association20030301

Title: Alvimopan (Adolor/GlaxoSmithKline).

Journal: Current opinion in investigational drugs (London, England : 2000)20021001

Title: Awakening the sleeping postsurgical abdomen.

Journal: Gastroenterology20020401

Title: Use of selective opiate receptor inhibitors to prevent postoperative ileus.

Journal: Minerva anestesiologica20020401

Title: Alvimopan* (ADL 8-2698) is a novel peripheral opioid antagonist.

Journal: American journal of surgery20011101

Title: Selective postoperative inhibition of gastrointestinal opioid receptors.

Journal: The New England journal of medicine20010927

Title: An opioid antagonist for postoperative ileus.

Journal: The New England journal of medicine20010927

Title: ADL 8-2698, a trans-3,4-dimethyl-4-(3-hydroxyphenyl) piperidine, prevents gastrointestinal effects of intravenous morphine without affecting analgesia.

Journal: Clinical pharmacology and therapeutics20010101

Title: Bourdonnec BL, et, al. Novel trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidines as mu opioid receptor antagonists with improved opioid receptor selectivity profiles. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2006-12.

Title: Erowele GI, et, al. Alvimopan (Entereg), a Peripherally Acting mu-Opioid Receptor Antagonist For Postoperative Ileus. P T. 2008 Oct;33(10):574-83.

Title: Meerveld BG, et, al. Preclinical studies of opioids and opioid antagonists on gastrointestinal function. Neurogastroenterol Motil. 2004 Oct;16 Suppl 2:46-53.

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1736-18-1
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