Name: Name:(S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1h-imidazole-2(3h)-thione hydrochloride
Brand: AABLOCKS
SKU: AA00ABLU
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00ABLU

Chemical Name: (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1h-imidazole-2(3h)-thione hydrochloride

CAS Number: 170151-24-3

Molecular Formula: C14H16ClF2N3S

Molecular Weight: 331.8117

MDL Number: MFCD00954638

SMILES: NCc1c[nH]c(=S)n1[C@H]1CCc2c(C1)cc(cc2F)F.Cl

Properties

Form: Solid

Storage: Inert atmosphere;-20 ℃;

Complexity: 429

Covalently-Bonded Unit Count: 2

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 21

Hydrogen Bond Acceptor Count: 4

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 2

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Literature fold

Title: Disulfiram attenuates drug-primed reinstatement of cocaine seeking via inhibition of dopamine β-hydroxylase.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20101101

Title: Effects of disulfiram and dopamine beta-hydroxylase knockout on cocaine-induced seizures.

Journal: Pharmacology, biochemistry, and behavior20080601

Title: Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.

Journal: Journal of medicinal chemistry20060209

Title: Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase.

Journal: British journal of pharmacology19970801

Title: Beliaev A, et al. Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.J Med Chem. 2006 Feb 9;49(3):1191-7.

Title: Stanley WC, et al. Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor. J Cardiovasc Pharmacol. 1998 Jun;31(6):963-70.

Title: Stanley WC, et al. Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase. Br J Pharmacol. 1997 Aug;121(8):1803-9.

Title: Sabbah HN, et al. Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.

170151-24-3 | (S)-5-(Aminomethyl)-1-(5,7-difluoro-1,2,3,4-tetrahydronaphthalen-2-yl)-1h-imidazole-2(3h)-thione hydrochloride