Title: S 18986 reverses spatial working memory impairments in aged mice: comparison with memantine.
Journal: Psychopharmacology20110601
Title: DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptors pharmacological profile of a novel cognitive enhancer.
Journal: CNS neuroscience & therapeutics20101001
Title: New fluorinated 1,2,4-benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors.
Journal: Journal of medicinal chemistry20100225
Title: The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis.
Journal: Neuropharmacology20090901
Title: GAP-43 is essential for the neurotrophic effects of BDNF and positive AMPA receptor modulator S18986.
Journal: Cell death and differentiation20090401
Title: Effects of the AMPA receptor modulator S 18986 on measures of cognition and oxidative stress in aged rats.
Journal: Psychopharmacology20090101
Title: Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators.
Journal: Bioorganic & medicinal chemistry20081201
Title: Behavioral and biological effects of chronic S18986, a positive AMPA receptor modulator, during aging.
Journal: Experimental neurology20080301
Title: Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil.
Journal: Psychopharmacology20070701
Title: Design, synthesis, and pharmacology of novel 7-substituted 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides as positive allosteric modulators of AMPA receptors.
Journal: Journal of medicinal chemistry20070628
Title: S18986: a positive modulator of AMPA-receptors enhances (S)-AMPA-mediated BDNF mRNA and protein expression in rat primary cortical neuronal cultures.
Journal: European journal of pharmacology20070430
Title: S 18986, a positive modulator of AMPA receptors with cognition-enhancing properties, increases ACh release in the hippocampus of young and aged rat.
Journal: Neuroscience letters20040506
Title: (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices.
Journal: European journal of pharmacology20000804
Title: Bernard K, et al. DRUG FOCUS: S 18986: A positive allosteric modulator of AMPA-type glutamate receptorspharmacological profile of a novel cognitive enhancer. CNS Neurosci Ther. 2010 Oct;16(5):e193-212.
Title: Bourasset F, et al. Neuropharmacokinetics of a new alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-,4cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide, in the rat. Drug Metab Dispos. 2005 Aug;33(8):1137-43.
