176796-64-8,MFCD06798364
Catalog No.:AA0024TX

176796-64-8 | 1,2-Benzenedicarboxylic acid, 4-(aminocarboxymethyl)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
10mg
As reported
2 weeks  
$890.00   $623.00
- +
50mg
As reported
2 weeks  
$2,061.00   $1,443.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0024TX
Chemical Name:
1,2-Benzenedicarboxylic acid, 4-(aminocarboxymethyl)-
CAS Number:
176796-64-8
Molecular Formula:
C10H9NO6
Molecular Weight:
239.1816
MDL Number:
MFCD06798364
SMILES:
NC(c1ccc(c(c1)C(=O)O)C(=O)O)C(=O)O
Properties
Computed Properties
 
Complexity:
342  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-2.7  

Literature

Title: Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110323

Title: Acute pharmacological modulation of mGluR8 reduces measures of anxiety.

Journal: Behavioural brain research 20101015

Title: Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses.

Journal: Neuroscience 20100331

Title: Behavioural profile of selective ligands for mGlu7 and mGlu8 glutamate receptors in agonistic encounters between mice.

Journal: Psicothema 20090801

Title: AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala.

Journal: Neuropharmacology 20080901

Title: Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors.

Journal: Neuropharmacology 20080901

Title: Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways.

Journal: Neuropharmacology 20080501

Title: Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid.

Journal: Neuropharmacology 20080301

Title: Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.

Journal: Journal of neurophysiology 20070701

Title: Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.

Journal: Brain research 20070604

Title: Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus.

Journal: Epilepsia 20070401

Title: Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.

Journal: Neuropharmacology 20070201

Title: Effects of the mGluR8 agonist (S)-3,4-DCPG in the lateral amygdala on acquisition/expression of fear-potentiated startle, synaptic transmission, and plasticity.

Journal: Neuropharmacology 20060201

Title: Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG.

Journal: European journal of pharmacology 20051228

Title: Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level.

Journal: Neuropharmacology 20050101

Title: Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats.

Journal: Pharmacological reports : PR 20050101

Title: Regulation of transmitter release by high-affinity group III mGluRs in the supraoptic nucleus of the rat hypothalamus.

Journal: Neuropharmacology 20040901

Title: Potential antipsychotic and extrapyramidal effects of (R,S)-3,4-dicarboxyphenylglycine [(R,S)-3,4-DCPG], a mixed AMPA antagonist/mGluR8 agonist.

Journal: Polish journal of pharmacology 20040101

Title: Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice.

Journal: Neuropharmacology 20030901

Title: Anticonvulsant dicarboxyphenylglycines differentially modulate excitatory amino acid release in the rat cerebral cortex.

Journal: Brain research 20030704

Title: Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG.

Journal: Neuropharmacology 20020801

Title: Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets.

Journal: American journal of physiology. Endocrinology and metabolism 20020601

Title: Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.

Journal: Neuropharmacology 20010401

Title: (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.

Journal: Neuropharmacology 20010301

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Tags:176796-64-8 Molecular Formula|176796-64-8 MDL|176796-64-8 SMILES|176796-64-8 1,2-Benzenedicarboxylic acid, 4-(aminocarboxymethyl)-
Catalog No.: AA0024TX
176796-64-8,MFCD06798364
176796-64-8 | 1,2-Benzenedicarboxylic acid, 4-(aminocarboxymethyl)-
Pack Size: 10mg
Purity: As reported
2 weeks
$890.00 $623.00
Pack Size: 50mg
Purity: As reported
2 weeks
$2,061.00 $1,443.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0024TX
Chemical Name: 1,2-Benzenedicarboxylic acid, 4-(aminocarboxymethyl)-
CAS Number: 176796-64-8
Molecular Formula: C10H9NO6
Molecular Weight: 239.1816
MDL Number: MFCD06798364
SMILES: NC(c1ccc(c(c1)C(=O)O)C(=O)O)C(=O)O
Properties
Complexity: 342  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 17  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 4  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: -2.7  
Literature fold

Title: Metabotropic glutamate receptor subtype 8 in the amygdala modulates thermal threshold, neurotransmitter release, and rostral ventromedial medulla cell activity in inflammatory pain.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110323

Title: Acute pharmacological modulation of mGluR8 reduces measures of anxiety.

Journal: Behavioural brain research20101015

Title: Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses.

Journal: Neuroscience20100331

Title: Behavioural profile of selective ligands for mGlu7 and mGlu8 glutamate receptors in agonistic encounters between mice.

Journal: Psicothema20090801

Title: AMN082, an allosteric mGluR7 agonist that inhibits afferent glutamatergic transmission in rat basolateral amygdala.

Journal: Neuropharmacology20080901

Title: Group III mGluR7 and mGluR8 in the amygdala differentially modulate nocifensive and affective pain behaviors.

Journal: Neuropharmacology20080901

Title: Anatomy and function of group III metabotropic glutamate receptors in gastric vagal pathways.

Journal: Neuropharmacology20080501

Title: Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid.

Journal: Neuropharmacology20080301

Title: Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.

Journal: Journal of neurophysiology20070701

Title: Evaluation of the mGlu8 receptor as a putative therapeutic target in schizophrenia.

Journal: Brain research20070604

Title: Anticonvulsive effect of a selective mGluR8 agonist (S)-3,4-dicarboxyphenylglycine (S-3,4-DCPG) in the mouse pilocarpine model of status epilepticus.

Journal: Epilepsia20070401

Title: Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.

Journal: Neuropharmacology20070201

Title: Effects of the mGluR8 agonist (S)-3,4-DCPG in the lateral amygdala on acquisition/expression of fear-potentiated startle, synaptic transmission, and plasticity.

Journal: Neuropharmacology20060201

Title: Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG.

Journal: European journal of pharmacology20051228

Title: Differential roles of mGlu8 receptors in the regulation of glutamate and gamma-aminobutyric acid release at periaqueductal grey level.

Journal: Neuropharmacology20050101

Title: Lack of the antianxiety-like effect of (S)-3,4-DCPG, an mGlu8 receptor agonist, after central administration in rats.

Journal: Pharmacological reports : PR20050101

Title: Regulation of transmitter release by high-affinity group III mGluRs in the supraoptic nucleus of the rat hypothalamus.

Journal: Neuropharmacology20040901

Title: Potential antipsychotic and extrapyramidal effects of (R,S)-3,4-dicarboxyphenylglycine [(R,S)-3,4-DCPG], a mixed AMPA antagonist/mGluR8 agonist.

Journal: Polish journal of pharmacology20040101

Title: Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice.

Journal: Neuropharmacology20030901

Title: Anticonvulsant dicarboxyphenylglycines differentially modulate excitatory amino acid release in the rat cerebral cortex.

Journal: Brain research20030704

Title: Reduction of excitatory transmission in the retino-collicular pathway via selective activation of mGlu8 receptors by DCPG.

Journal: Neuropharmacology20020801

Title: Localization and function of group III metabotropic glutamate receptors in rat pancreatic islets.

Journal: American journal of physiology. Endocrinology and metabolism20020601

Title: Anticonvulsant activity of 3,4-dicarboxyphenylglycines in DBA/2 mice.

Journal: Neuropharmacology20010401

Title: (S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.

Journal: Neuropharmacology20010301

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