178419-45-9,MFCD21266569
Catalog No.:AA0025XW

178419-45-9 | Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one

Pack Size
Purity
Availability
Price(USD)
Quantity
  
50mg
95%
3 weeks  
$467.00   $327.00
- +
100mg
95%
3 weeks  
$668.00   $468.00
- +
250mg
95%
3 weeks  
$927.00   $649.00
- +
500mg
95%
3 weeks  
$1,429.00   $1,000.00
- +
1g
95%
3 weeks  
$1,818.00   $1,273.00
- +
2.5g
95%
3 weeks  
$3,506.00   $2,454.00
- +
5g
95%
3 weeks  
$5,161.00   $3,613.00
- +
10g
95%
3 weeks  
$7,622.00   $5,335.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0025XW
Chemical Name:
Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
CAS Number:
178419-45-9
Molecular Formula:
C9H14N2O2
Molecular Weight:
182.2197
MDL Number:
MFCD21266569
SMILES:
O=C1NCC2(O1)CN1CCC2CC1
Properties
Computed Properties
 
Complexity:
248  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
0  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
0.2  

Literature

Title: In vitro binding characteristics of [3H]AZ11637326, a novel alpha7-selective neuronal nicotinic receptor agonist radioligand.

Journal: European journal of pharmacology 20101025

Title: Young and older good learners have higher levels of brain nicotinic receptor binding.

Journal: Neurobiology of aging 20100601

Title: Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis.

Journal: British journal of pharmacology 20100501

Title: Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.

Journal: British journal of pharmacology 20100201

Title: Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.

Journal: Arthritis and rheumatism 20090101

Title: Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20081101

Title: [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain.

Journal: The Journal of pharmacology and experimental therapeutics 20080101

Title: Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice.

Journal: Gastroenterology 20071001

Title: The cholinergic anti-inflammatory pathway and the gastrointestinal tract.

Journal: Gastroenterology 20071001

Title: Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Journal: Journal of medicinal chemistry 20050728

Title: A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist.

Journal: The Journal of organic chemistry 20040917

Title: Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.

Journal: Bioorganic & medicinal chemistry letters 20040419

Title: AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors.

Journal: Psychopharmacology 20040401

Title: Attentional effects of nicotinic agonists in rats.

Journal: Neuropharmacology 20030601

Title: Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.

Journal: European journal of pharmacology 20030124

Title: Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus.

Journal: The Journal of physiology 20011001

Title: The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?

Journal: Psychopharmacology 20010701

Title: Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

Journal: The Journal of pharmacology and experimental therapeutics 20000901

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SDS
Tags:178419-45-9 Molecular Formula|178419-45-9 MDL|178419-45-9 SMILES|178419-45-9 Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
Catalog No.: AA0025XW
178419-45-9,MFCD21266569
178419-45-9 | Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
Pack Size: 50mg
Purity: 95%
3 weeks
$467.00 $327.00
Pack Size: 100mg
Purity: 95%
3 weeks
$668.00 $468.00
Pack Size: 250mg
Purity: 95%
3 weeks
$927.00 $649.00
Pack Size: 500mg
Purity: 95%
3 weeks
$1,429.00 $1,000.00
Pack Size: 1g
Purity: 95%
3 weeks
$1,818.00 $1,273.00
Pack Size: 2.5g
Purity: 95%
3 weeks
$3,506.00 $2,454.00
Pack Size: 5g
Purity: 95%
3 weeks
$5,161.00 $3,613.00
Pack Size: 10g
Purity: 95%
3 weeks
$7,622.00 $5,335.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0025XW
Chemical Name: Spiro[1-azabicyclo[2.2.2]octane-3,5'-oxazolidin]-2'-one
CAS Number: 178419-45-9
Molecular Formula: C9H14N2O2
Molecular Weight: 182.2197
MDL Number: MFCD21266569
SMILES: O=C1NCC2(O1)CN1CCC2CC1
Properties
Complexity: 248  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 0  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 0.2  
Literature fold

Title: In vitro binding characteristics of [3H]AZ11637326, a novel alpha7-selective neuronal nicotinic receptor agonist radioligand.

Journal: European journal of pharmacology20101025

Title: Young and older good learners have higher levels of brain nicotinic receptor binding.

Journal: Neurobiology of aging20100601

Title: Selective alpha7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis.

Journal: British journal of pharmacology20100501

Title: Activation of presynaptic alpha7 nicotinic receptors evokes an excitatory response in hippocampal CA3 neurones in anaesthetized rats: an in vivo iontophoretic study.

Journal: British journal of pharmacology20100201

Title: Stimulation of nicotinic acetylcholine receptors attenuates collagen-induced arthritis in mice.

Journal: Arthritis and rheumatism20090101

Title: Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors.

Journal: The Journal of pharmacology and experimental therapeutics20081101

Title: [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain.

Journal: The Journal of pharmacology and experimental therapeutics20080101

Title: Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice.

Journal: Gastroenterology20071001

Title: The cholinergic anti-inflammatory pathway and the gastrointestinal tract.

Journal: Gastroenterology20071001

Title: Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Journal: Journal of medicinal chemistry20050728

Title: A chiral synthesis of (-)-spiro[1-azabicyclo[2.2.2]octane-3,5'- oxazolidin-2'-one]: a conformationally restricted analogue of acetylcholine that is a potent and selective alpha7 nicotinic receptor agonist.

Journal: The Journal of organic chemistry20040917

Title: Activity of alpha7-selective agonists at nicotinic and serotonin 5HT3 receptors expressed in Xenopus oocytes.

Journal: Bioorganic & medicinal chemistry letters20040419

Title: AR-R 17779 improves social recognition in rats by activation of nicotinic alpha7 receptors.

Journal: Psychopharmacology20040401

Title: Attentional effects of nicotinic agonists in rats.

Journal: Neuropharmacology20030601

Title: Role of muscarinic receptors in the activation of the ventral subiculum and the consequences for dopamine release in the nucleus accumbens.

Journal: European journal of pharmacology20030124

Title: Regulation of GABA release by nicotinic acetylcholine receptors in the neonatal rat hippocampus.

Journal: The Journal of physiology20011001

Title: The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics?

Journal: Psychopharmacology20010701

Title: Evidence that nicotinic alpha(7) receptors are not involved in the hyperlocomotor and rewarding effects of nicotine.

Journal: The Journal of pharmacology and experimental therapeutics20000901

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