+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
178946-89-9,MFCD05625919
Catalog No.:AA0026FS

178946-89-9 | C-Dim12

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$72.00   $50.00
- +
10mg
≥98%
in stock  
$135.00   $94.00
- +
25mg
≥98%
in stock  
$299.00   $209.00
- +
100mg
≥98%
in stock  
$833.00   $583.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0026FS
Chemical Name:
C-Dim12
CAS Number:
178946-89-9
Molecular Formula:
C23H17ClN2
Molecular Weight:
356.8475
MDL Number:
MFCD05625919
SMILES:
Clc1ccc(cc1)C(c1c[nH]c2c1cccc2)c1c[nH]c2c1cccc2
Properties
Computed Properties
 
Complexity:
443  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
0  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
3  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
6.2  

Literature

Title: Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20150201

Title: 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.

Journal: Molecular cancer therapeutics 20081201

Title: De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub 2015 Apr 9.

Title: Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 178946-89-9
1968-05-4

1968-05-4

 1441421-47-1

1441421-47-1

 1146080-32-1

1146080-32-1

 32863-87-9

32863-87-9

 5275-07-0

5275-07-0

 5275-04-7

5275-04-7
Building Blocks
More >
Historical Records
444184-81-0

444184-81-0
Tags:178946-89-9 Molecular Formula|178946-89-9 MDL|178946-89-9 SMILES|178946-89-9 C-Dim12
Catalog No.: AA0026FS
178946-89-9,MFCD05625919
178946-89-9 | C-Dim12
Pack Size： 5mg
Purity： ≥98%
in stock
$72.00 $50.00
Pack Size： 10mg
Purity： ≥98%
in stock
$135.00 $94.00
Pack Size： 25mg
Purity： ≥98%
in stock
$299.00 $209.00
Pack Size： 100mg
Purity： ≥98%
in stock
$833.00 $583.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0026FS
Chemical Name: C-Dim12
CAS Number: 178946-89-9
Molecular Formula: C23H17ClN2
Molecular Weight: 356.8475
MDL Number: MFCD05625919
SMILES: Clc1ccc(cc1)C(c1c[nH]c2c1cccc2)c1c[nH]c2c1cccc2
Properties
Complexity: 443  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 0  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 3  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 6.2  
Literature fold

Title: Novel para-phenyl substituted diindolylmethanes protect against MPTP neurotoxicity and suppress glial activation in a mouse model of Parkinson's disease.

Journal: Toxicological sciences : an official journal of the Society of Toxicology20150201

Title: 1,1-Bis(3'-indolyl)-1-(p-chlorophenyl)methane activates the orphan nuclear receptor Nurr1 and inhibits bladder cancer growth.

Journal: Molecular cancer therapeutics20081201

Title: De Miranda BR, et al. The Nurr1 Activator 1,1-Bis(3'-Indolyl)-1-(p-Chlorophenyl)Methane Blocks Inflammatory Gene Expression in BV-2 Microglial Cells by Inhibiting Nuclear Factor κB. Mol Pharmacol. 2015 Jun;87(6):1021-34. doi: 10.1124/mol.114.095398. Epub 2015 Apr 9.

Title: Hammond SL, et al. A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Neurosci Lett. 2015 Oct 21;607:83-9.

Related Products of of 178946-89-9
1968-05-4
1968-05-4
1441421-47-1
1441421-47-1
1146080-32-1
1146080-32-1
32863-87-9
32863-87-9
5275-07-0
5275-07-0
5275-04-7
5275-04-7
Building Blocks More >
1792-40-1
1792-40-1
2-Methyl-5-nitro-1H-1,3-benzodiazole
AA0026SF | MFCD00005599
17960-37-1
17960-37-1
4-(2-Furyl)-4-oxobutanenitrile
AA00271H | MFCD04114933
179897-90-6
179897-90-6
1-Chloro-2,6-dibromo-4-fluorobenzene
AA0027A1 | MFCD00061122
18358-63-9
18358-63-9
6-Methyl-1h-pyrrolo[3,2-c]pyridine
AA0027N6 | MFCD00017198
20201-39-2
20201-39-2
Butanoic acid, 2-bromo-3,3-dimethyl-, ethyl ester
AA0027Y3 | MFCD00068976
20282-39-7
20282-39-7
2,5-Dimethyl-1-propyl-1H-pyrrole
AA0028DR | MFCD04618252
203000-48-0
203000-48-0
(S,S)-1,2-Bis[(tert-butyl)methylphosphino]ethane bis(borane)
AA0028K8 | MFCD03844770
203503-03-1
203503-03-1
1-Piperidinecarboxylic acid, 4-amino-3-hydroxy-, 1,1-dimethylethyl ester
AA0028UH | MFCD17016124
20374-48-5
20374-48-5
2-Cyano-3-(p-tolyl)acrylic acid
AA002915 | MFCD01313927
20430-18-6
20430-18-6
Benzeneacetic acid, α,α,4-trimethyl-
AA0029BX | MFCD11036959
Historical Records
444184-81-0
444184-81-0
Submit
© 2017 AA BLOCKS, INC. All rights reserved.