Name: Name:LY 344864
Brand: AABLOCKS
SKU: AA007S7F
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA007S7F

Chemical Name: LY 344864

CAS Number: 186544-26-3

Molecular Formula: C21H23ClFN3O

Molecular Weight: 387.8782

MDL Number: MFCD07772184

SMILES: CN([C@@H]1CCc2c(C1)c1cc(ccc1[nH]2)NC(=O)c1ccc(cc1)F)C.Cl

Properties

Complexity: 506

Covalently-Bonded Unit Count: 2

Defined Atom Stereocenter Count: 1

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 27

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 3

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

Literature fold

Title: Preparation of 8-Amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and several fluorinated derivatives via [3,3]-sigmatropic rearrangement of O-aryloximes.

Journal: The Journal of organic chemistry20030207

Title: 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.

Journal: Cephalalgia : an international journal of headache20020601

Title: Serotonin-induced contraction in mesenteric resistance arteries: signaling and changes in deoxycorticosterone acetate-salt hypertension.

Journal: Hypertension (Dallas, Tex. : 1979)20020301

Title: Sumatriptan elicits both constriction and dilation in human and bovine brain intracortical arterioles.

Journal: British journal of pharmacology20010101

Title: Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine.

Journal: Life sciences19970101

Title: Phebus LA, Johnson KW, Zgombick JM, Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brainpenetration and activity in the neurogenic dural inflammation model of migraine. Life Sci. 1997;61(21):2117-26.

Title: Jeong HJ, Chenu D, Johnson EE, Sumatriptan inhibits synaptic transmission in the rat midbrain periaqueductal grey. Mol Pain. 2008 Nov 11;4:54.

Title: Cohen ML, Schenck K. 5-Hydroxytryptamine(1F) receptors do not participate in vasoconstriction: lack of vasoconstriction to LY344864, a selective serotonin(1F) receptor agonist in rabbit saphenous vein. J Pharmacol Exp Ther. 1999 Sep;290(3):935-9.

186544-26-3 | LY 344864