Name: Name:Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-
Brand: AABLOCKS
SKU: AA002GRM
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA002GRM

Chemical Name: Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-

CAS Number: 188343-77-3

Molecular Formula: C21H22FN3

Molecular Weight: 335.4179

MDL Number: MFCD30474871

SMILES: CN1CCC(CC1)c1[nH]c(c(c1)c1ccncc1)c1ccc(cc1)F

Properties

Complexity: 409

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 25

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 3

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.6

Literature fold

Title: A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes.

Journal: Science (New York, N.Y.)20100514

Title: Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase.

Journal: Molecular and biochemical parasitology20060901

Title: Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity.

Journal: Journal of natural products20060401

Title: Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor.

Journal: Molecular and biochemical parasitology20060301

Title: Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.

Journal: Bioorganic & medicinal chemistry letters20050701

Title: Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.

Journal: Journal of natural products20050401

Title: A role for coccidian cGMP-dependent protein kinase in motility and invasion.

Journal: International journal for parasitology20040309

Title: Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase.

Journal: Eukaryotic cell20020601

Title: Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target.

Journal: The Journal of biological chemistry20020503

Title: Nare B, et al. Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy. Antimicrob Agents Chemother. 2002 Feb;46(2):300-7.

188343-77-3 | Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-