Title: Perinatal exposure to low-dose of bisphenol A causes anxiety-like alteration in adrenal axis regulation and behaviors of rat offspring: a potential role for metabotropic glutamate 2/3 receptors.

Journal: Journal of psychiatric research20150501

Title: S-SCAM, a rare copy number variation gene, induces schizophrenia-related endophenotypes in transgenic mouse model.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20150204

Title: HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors.

Journal: Molecular pain20140101

Title: Glutamate transporters and presynaptic metabotropic glutamate receptors protect neocortical Cajal-Retzius cells against over-excitation.

Journal: Pflugers Archiv : European journal of physiology20120801

Title: Nicotine exposure during adolescence leads to short- and long-term changes in spike timing-dependent plasticity in rat prefrontal cortex.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20120801

Title: The group 2 metabotropic glutamate receptor agonist LY379268 rescues neuronal, neurochemical and motor abnormalities in R6/2 Huntington's disease mice.

Journal: Neurobiology of disease20120701

Title: Potentiation of synaptic strength and intrinsic excitability in the nucleus accumbens after 10 days of morphine withdrawal.

Journal: Journal of neuroscience research20120601

Title: (-)-2-oxa-4-aminobicylco[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) and 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]piperidine (MTEP) similarly attenuate stress-induced reinstatement of cocaine seeking.

Journal: Addiction biology20120501

Title: Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.

Journal: Psychopharmacology20120301

Title: On the mechanism of anti-hyperthermic effects of LY379268 and LY487379, group II mGlu receptors activators, in the stress-induced hyperthermia in singly housed mice.

Journal: Neuropharmacology20120101

Title: Pre-treatment with the mGlu2/3 receptor agonist LY379268 attenuates DOI-induced impulsive responding and regional c-Fos protein expression.

Journal: Psychopharmacology20120101

Title: Spike-timing precision and neuronal synchrony are enhanced by an interaction between synaptic inhibition and membrane oscillations in the amygdala.

Journal: PloS one20120101

Title: Enhanced sensitivity to attenuation of conditioned reinstatement by the mGluR 2/3 agonist LY379268 and increased functional activity of mGluR 2/3 in rats with a history of ethanol dependence.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20111201

Title: Activation of group II metabotropic glutamate receptors induces long-term depression of excitatory synaptic transmission in the substantia nigra pars reticulata.

Journal: Neuroscience letters20111024

Title: Activation of group II metabotropic glutamate receptors inhibits the discriminative stimulus effects of alcohol via selective activity within the amygdala.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20111001

Title: Interaction of mGlu2/3 agonism with clozapine and lurasidone to restore novel object recognition in subchronic phencyclidine-treated rats.

Journal: Psychopharmacology20110901

Title: The metabotropic glutamate 2/3 receptor agonist LY379268 blocked nicotine-induced increases in nucleus accumbens shell dopamine only in the presence of a nicotine-associated context in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20110901

Title: Recent progress in the synthesis and characterization of group II metabotropic glutamate receptor allosteric modulators.

Journal: ACS chemical neuroscience20110817

Title: The role of 5-hydroxytryptamine 7 receptors in the phencyclidine-induced novel object recognition deficit in rats.

Journal: The Journal of pharmacology and experimental therapeutics20110801

Title: Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268.

Journal: Journal of neurochemistry20110601

Title: Acute administration of typical and atypical antipsychotics reduces EEG γ power, but only the preclinical compound LY379268 reduces the ketamine-induced rise in γ power.

Journal: The international journal of neuropsychopharmacology20110601

Title: Attention deficit induced by blockade of N-methyl D-aspartate receptors in the prefrontal cortex is associated with enhanced glutamate release and cAMP response element binding protein phosphorylation: role of metabotropic glutamate receptors 2/3.

Journal: Neuroscience20110310

Title: Early defect of transforming growth factor β1 formation in Huntington's disease.

Journal: Journal of cellular and molecular medicine20110301

Title: Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus.

Journal: The Journal of pharmacology and experimental therapeutics20110301

Title: Targeting group II metabotropic glutamate (mGlu) receptors for the treatment of psychosis associated with Alzheimer's disease: selective activation of mGlu2 receptors amplifies beta-amyloid toxicity in cultured neurons, whereas dual activation of mGlu2 and mGlu3 receptors is neuroprotective.

Journal: Molecular pharmacology20110301

Title: Awake rat pharmacological magnetic resonance imaging as a translational pharmacodynamic biomarker: metabotropic glutamate 2/3 agonist modulation of ketamine-induced blood oxygenation level dependence signals.

Journal: The Journal of pharmacology and experimental therapeutics20110301

Title: Design and synthesis of an orally active metabotropic glutamate receptor subtype-2 (mGluR2) positive allosteric modulator (PAM) that decreases cocaine self-administration in rats.

Journal: Journal of medicinal chemistry20110113

Title: Absence of direct effects on the dopamine D2 receptor by mGluR2/3-selective receptor agonists LY 354,740 and LY 379,268.

Journal: Synapse (New York, N.Y.)20110101

Title: mGlu2 metabotropic glutamate receptors restrain inflammatory pain and mediate the analgesic activity of dual mGlu2/mGlu3 receptor agonists.

Journal: Molecular pain20110101

Title: Reduced cAMP, Akt activation and p65-c-Rel dimerization: mechanisms involved in the protective effects of mGluR3 agonists in cultured astrocytes.

Journal: PloS one20110101

Title: More is less: a disinhibited prefrontal cortex impairs cognitive flexibility.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20101215

Title: The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward function in rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20100901

Title: Effects of metabotropic glutamate receptor 2/3 agonism and antagonism on schizophrenia-like cognitive deficits induced by phencyclidine in rats.

Journal: European journal of pharmacology20100810

Title: Behavioral and functional evidence of metabotropic glutamate receptor 2/3 and metabotropic glutamate receptor 5 dysregulation in cocaine-escalated rats: factor in the transition to dependence.

Journal: Biological psychiatry20100801

Title: Interhemispheric regulation of the medial prefrontal cortical glutamate stress response in rats.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100602

Title: Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake.

Journal: Biological psychiatry20100501

Title: The mGluR2/3 agonist LY379268 blocks the effects of GLT-1 upregulation on prepulse inhibition of the startle reflex in adult rats.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20100501

Title: Alcohol-induced neurodegeneration, suppression of transforming growth factor-beta, and cognitive impairment in rats: prevention by group II metabotropic glutamate receptor activation.

Journal: Biological psychiatry20100501

Title: Effects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependence.

Journal: Biological psychiatry20100501

Title: The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice.

Journal: Psychopharmacology20100501

Title: Activation of metabotropic glutamate (mGlu)2 receptors suppresses histamine release in limbic brain regions following acute ketamine challenge.

Journal: Neuropharmacology20100301

Title: Inhibition of NAALADase by 2-PMPA attenuates cocaine-induced relapse in rats: a NAAG-mGluR2/3-mediated mechanism.

Journal: Journal of neurochemistry20100101

Title: Metabotropic glutamate receptor 3 activation prevents nitric oxide-induced death in cultured rat astrocytes.

Journal: Journal of neurochemistry20100101

Title: Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain.

Journal: Pain20091215

Title: In vitro and in vivo evidence for a lack of interaction with dopamine D2 receptors by the metabotropic glutamate 2/3 receptor agonists 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-bicaroxylate monohydrate (LY354740) and (-)-2-oxa-4-aminobicyclo[3.1.0] Hexane-4,6-dicarboxylic acid (LY379268).

Journal: The Journal of pharmacology and experimental therapeutics20091201

Title: Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys.

Journal: Pharmacology, biochemistry, and behavior20091101

Title: Glutamate agonists for treating schizophrenia have affinity for dopamine D2High and D3 receptors.

Journal: Synapse (New York, N.Y.)20090801

Title: Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice.

Journal: Molecular pharmacology20090801

Title: Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20090501

Title: Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain.

Journal: Molecular pharmacology20090501

Title: Enhanced sensitivity to group II mGlu receptor activation at corticostriatal synapses in mice lacking the familial parkinsonism-linked genes PINK1 or Parkin.

Journal: Experimental neurology20090201

Title: The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.

Journal: Brain research20090116

Title: Activation of mGlu3 receptors stimulates the production of GDNF in striatal neurons.

Journal: PloS one20090101

Title: Loss of glial glutamate and aspartate transporter (excitatory amino acid transporter 1) causes locomotor hyperactivity and exaggerated responses to psychotomimetics: rescue by haloperidol and metabotropic glutamate 2/3 agonist.

Journal: Biological psychiatry20081101

Title: Phencyclidine and glutamate agonist LY379268 stimulate dopamine D2High receptors: D2 basis for schizophrenia.

Journal: Synapse (New York, N.Y.)20081101

Title: Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain.

Journal: Pain20080930

Title: Defective group-II metaboropic glutamate receptors in the hippocampus of spontaneously depressed rats.

Journal: Neuropharmacology20080901

Title: Chronic phenethylamine hallucinogen treatment alters behavioral sensitivity to a metabotropic glutamate 2/3 receptor agonist.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20080801

Title: Rats with extended access to cocaine exhibit increased stress reactivity and sensitivity to the anxiolytic-like effects of the mGluR 2/3 agonist LY379268 during abstinence.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20080701

Title: The role of NMDA receptors in regulating group II metabotropic glutamate receptor-mediated long-term depression in rat medial prefrontal cortex.

Journal: Neuropharmacology20080601

Title: Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice.

Journal: Alcohol (Fayetteville, N.Y.)20080501

Title: Dopamine partial agonist actions of the glutamate receptor agonists LY 354,740 and LY 379,268.

Journal: Synapse (New York, N.Y.)20080201

Title: The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity.

Journal: Psychopharmacology20080201

Title: Glutamate agonists for schizophrenia stimulate dopamine D2High receptors.

Journal: Schizophrenia research20080201

Title: Synergism between fluoxetine and the mGlu2/3 receptor agonist, LY379268, in an in vitro model for antidepressant drug-induced neurogenesis.

Journal: Neuropharmacology20080201

Title: Metabotropic glutamate 2/3 receptor activation induced reward deficits but did not aggravate brain reward deficits associated with spontaneous nicotine withdrawal in rats.

Journal: Biochemical pharmacology20071015

Title: Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20070822

Title: Systemic and central amygdala injections of the mGluR2/3 agonist LY379268 attenuate the expression of incubation of sucrose craving in rats.

Journal: Behavioural brain research20070806

Title: Molecular signalling mediating the protective effect of A1 adenosine and mGlu3 metabotropic glutamate receptor activation against apoptosis by oxygen/glucose deprivation in cultured astrocytes.

Journal: Molecular pharmacology20070501

Title: Systemic and central amygdala injections of the mGluR(2/3) agonist LY379268 attenuate the expression of incubation of cocaine craving.

Journal: Biological psychiatry20070301

Title: Pharmacological activation of mGlu2/3 metabotropic glutamate receptors protects retinal neurons against anoxic damage in the goldfish Carassius auratus.

Journal: Experimental eye research20070301

Title: Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors.

Journal: Journal of medicinal chemistry20070125

Title: The preclinical properties of a novel group II metabotropic glutamate receptor agonist LY379268.

Journal: CNS drug reviews20070101

Title: The mGluR2/3 agonist LY379268 attenuates context- and discrete cue-induced reinstatement of sucrose seeking but not sucrose self-administration in rats.

Journal: Behavioural brain research20061002

Title: Activation of group II metabotropic glutamate receptors in the nucleus accumbens shell attenuates context-induced relapse to heroin seeking.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20061001

Title: Blockade of group II metabotropic glutamate receptors in the nucleus accumbens produces hyperlocomotion in rats previously exposed to amphetamine.

Journal: Neuropharmacology20061001

Title: Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20060927

Title: Unique presynaptic and postsynaptic roles of Group II metabotropic glutamate receptors in the modulation of thalamic network activity.

Journal: Neuroscience20060811

Title: Pharmacological stimulation of group ii metabotropic glutamate receptors reduces cocaine self-administration and cocaine-induced reinstatement of drug seeking in squirrel monkeys.

Journal: The Journal of pharmacology and experimental therapeutics20060801

Title: Effects of the mGluR2/3 agonist LY379268 on ketamine-evoked behaviours and neurochemical changes in the dentate gyrus of the rat.

Journal: Pharmacology, biochemistry, and behavior20060701

Title: The group II metabotropic glutamate receptor agonist, LY379268, inhibits both cocaine- and food-seeking behavior in rats.

Journal: Psychopharmacology20060601

Title: Neuroprotective effects of selective group II mGluR activation in brain trauma and traumatic neuronal injury.

Journal: Journal of neurotrauma20060201

Title: Suppression of alcohol self-administration and cue-induced reinstatement of alcohol seeking by the mGlu2/3 receptor agonist LY379268 and the mGlu8 receptor agonist (S)-3,4-DCPG.

Journal: European journal of pharmacology20051228

Title: A selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity.

Journal: The Journal of pharmacology and experimental therapeutics20051201

Title: Presynaptic inhibition of corticothalamic feedback by metabotropic glutamate receptors.

Journal: Journal of neurophysiology20050701

Title: The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking.

Journal: Neuroreport20050621

Title: Comparison of the effects of diazepam, the CRF1 antagonist CP-154,526 and the group II mGlu receptor agonist LY379268 on stress-evoked extracellular norepinephrine levels.

Journal: Neuropharmacology20050601

Title: Phencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGLU(2/3) receptor agonist LY379268.

Journal: Psychopharmacology20050401

Title: The metabotropic glutamate (mGLU)2/3 receptor antagonist LY341495 [2S-2-amino-2-(1S,2S-2-carboxycyclopropyl-1-yl)-3-(xanth-9-yl)propanoic acid] stimulates waking and fast electroencephalogram power and blocks the effects of the mGLU2/3 receptor agonist ly379268 [(-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate] in rats.

Journal: The Journal of pharmacology and experimental therapeutics20050201

Title: Activation of group II mGlu receptors blocks the enhanced drug taking induced by previous exposure to amphetamine.

Journal: The European journal of neuroscience20050101

Title: Analgesic effects of the selective group II (mGlu2/3) metabotropic glutamate receptor agonists LY379268 and LY389795 in persistent and inflammatory pain models after acute and repeated dosing.

Journal: Neuropharmacology20050101

Title: The mGlu2/3 receptor agonist LY379268 injected into cortex or thalamus decreases neuronal injury in retrosplenial cortex produced by NMDA receptor antagonist MK-801: possible implications for psychosis.

Journal: Neuropharmacology20041201

Title: A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20041124

Title: The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease.

Journal: Brain research20040903

Title: Selective action of (-)-2-oxa-4-aminobicyclo[3.1.0]hexane-4,6-dicarboxylate (LY379268), a group II metabotropic glutamate receptor agonist, on basal and phencyclidine-induced dopamine release in the nucleus accumbens shell.

Journal: Neuropharmacology20040701

Title: Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20040519

Title: In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands.

Journal: Journal of neurochemistry20040301

Title: Protective effect of LY379268, a selective group II metabotropic glutamate receptor agonist, on dizocilpine-induced neuropathological changes in rat retrosplenial cortex.

Journal: Brain research20031128

Title: Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20030901

Title: Toluene-induced locomotor activity is blocked by 6-hydroxydopamine lesions of the nucleus accumbens and the mGluR2/3 agonist LY379268.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20030801

Title: Protective role of group-II metabotropic glutamate receptors against nigro-striatal degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice.

Journal: Neuropharmacology20030801

Title: Effects of LY379268, a selective group II metabotropic glutamate receptor agonist on EEG activity, cortical perfusion, tissue damage, and cortical glutamate, glucose, and lactate levels in brain-injured rats.

Journal: Journal of neurotrauma20030401

Title: Pharmacological blockade of mGlu2/3 metabotropic glutamate receptors reduces cell proliferation in cultured human glioma cells.

Journal: Journal of neurochemistry20030301

Title: Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

Journal: Neuroscience20030101

Title: The group II metabotropic glutamate receptor agonist (-)-2-oxa-4-aminobicyclo[3.1.0.]hexane-4,6-dicarboxylate (LY379268) and clozapine reverse phencyclidine-induced behaviors in monoamine-depleted rats.

Journal: The Journal of pharmacology and experimental therapeutics20021201

Title: Modulation of stress-induced and stimulated hyperprolactinemia with the group II metabotropic glutamate receptor selective agonist, LY379268.

Journal: Neuropharmacology20021001

Title: Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.

Journal: Journal of medicinal chemistry20020912

Title: Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice.