1977-10-2,MFCD00242836
Catalog No.:AA002AW1

1977-10-2 | Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
10mM in DMSO
in stock  
$206.00   $144.00
- +
500mg
10mM in DMSO
in stock  
$566.00   $397.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA002AW1
Chemical Name:
Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
CAS Number:
1977-10-2
Molecular Formula:
C18H18ClN3O
Molecular Weight:
327.8080
MDL Number:
MFCD00242836
SMILES:
CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2
Properties
Computed Properties
 
Complexity:
450  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0  
Isotope Atom Count:
0  
Rotatable Bond Count:
1  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.1  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: [Dysphagia or dysphagias during neuroleptic medication?].

Journal: L'Encephale 20120901

Title: The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium.

Journal: Journal of clinical psychopharmacology 20120401

Title: The antipsychotic drug loxapine is an opener of the sodium-activated potassium channel slack (Slo2.2).

Journal: The Journal of pharmacology and experimental therapeutics 20120301

Title: Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder.

Journal: International journal of clinical practice 20120301

Title: Loxapine P-glycoprotein interactions in vitro.

Journal: Drug metabolism letters 20120301

Title: New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.

Journal: Journal of medicinal chemistry 20120223

Title: Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine.

Journal: Bipolar disorders 20120201

Title: [RÉALITÉ LT, a pharmacoepidemiological study of semiology and therapeutic strategy of patients with schizophrenia treated by antipsychotic loxapine in routine clinical practice].

Journal: L'Encephale 20120201

Title: The oxidative degradation of dibenzoazepine derivatives by cerium(IV) complexes in acidic sulfate media.

Journal: Dalton transactions (Cambridge, England : 2003) 20120128

Title: Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis 20120125

Title: Modeling psychiatric disorders through reprogramming.

Journal: Disease models & mechanisms 20120101

Title: Now take a deep breath: inhaled loxapine for the treatment of acute agitation.

Journal: Journal of psychosocial nursing and mental health services 20120101

Title: The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.

Journal: Parkinson's disease 20120101

Title: Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study.

Journal: BMJ (Clinical research ed.) 20120101

Title: Heart rate-corrected QT interval helps predict mortality after intentional organophosphate poisoning.

Journal: PloS one 20120101

Title: Palladium-catalyzed reaction of aryl iodides with ortho-bromoanilines and norbornene/norbornadiene: unexpected formation of dibenzoazepine derivatives.

Journal: Angewandte Chemie (International ed. in English) 20111216

Title: Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal.

Journal: Journal of addiction medicine 20111201

Title: Swallowing difficulties: a prognostic signpost.

Journal: Canadian family physician Medecin de famille canadien 20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology 20111201

Title: Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial.

Journal: The Journal of clinical psychiatry 20111001

Title: In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine.

Journal: Biopharmaceutics & drug disposition 20111001

Title: The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20111001

Title: 'Extended' antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind, placebo-controlled trial.

Journal: The Journal of clinical psychiatry 20110801

Title: Inhaled loxapine reduces acute agitation in people with schizophrenia compared with placebo.

Journal: Evidence-based mental health 20110801

Title: New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors.

Journal: Chemical biology & drug design 20110701

Title: Combination loxapine and aripiprazole for refractory hallucinations in schizophrenia.

Journal: The Annals of pharmacotherapy 20110701

Title: Quality of life after electroconvulsive therapy in persons with treatment resistant schizophrenia.

Journal: The Indian journal of medical research 20110601

Title: The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders.

Journal: Current neuropharmacology 20110601

Title: Modelling schizophrenia using human induced pluripotent stem cells.

Journal: Nature 20110512

Title: The benefits of an active control arm.

Journal: The British journal of psychiatry : the journal of mental science 20110401

Title: Aerosolised antipsychotic assuages agitation: inhaled loxapine for agitation associated with schizophrenia or bipolar disorder.

Journal: International journal of clinical practice 20110301

Title: Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study.

Journal: Journal of computer-aided molecular design 20110201

Title: In vitro aerosol characterization of Staccato(®) Loxapine.

Journal: International journal of pharmaceutics 20110117

Title: Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine.

Journal: The British journal of psychiatry : the journal of mental science 20110101

Title: Meeting on big mutations addresses big questions in human genetics.

Journal: Genome medicine 20110101

Title: Pharmacotherapy for treatment-resistant schizophrenia.

Journal: Neuropsychiatric disease and treatment 20110101

Title: Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report.

Journal: Child and adolescent psychiatry and mental health 20110101

Title: Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.

Journal: PloS one 20110101

Title: Homicide and associated steroid acute psychosis: a case report.

Journal: Case reports in medicine 20110101

Title: Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma.

Journal: Bioanalysis 20101201

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: In vitro aerosol deposition in the oropharyngeal region for Staccato loxapine.

Journal: Journal of aerosol medicine and pulmonary drug delivery 20100801

Title: 4-Nitro-2-phenoxy-aniline.

Journal: Acta crystallographica. Section E, Structure reports online 20100601

Title: Pharmacokinetics of loxapine following inhalation of a thermally generated aerosol in healthy volunteers.

Journal: Journal of clinical pharmacology 20100201

Title: [Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up].

Journal: L'Encephale 20100201

Title: Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28.

Journal: Bioorganic & medicinal chemistry 20100115

Title: Simultaneous HPLC determination of 14 tricyclic antidepressants and metabolites in human plasma.

Journal: Journal of separation science 20100101

Title: Identifying unexpected therapeutic targets via chemical-protein interactome.

Journal: PloS one 20100101

Title: Beneficial effects of loxapine on agitation and breathing patterns during weaning from mechanical ventilation.

Journal: Critical care (London, England) 20100101

Title: Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data.

Journal: BMC bioinformatics 20100101

Title: Pharmacological interventions for borderline personality disorder.

Journal: The Cochrane database of systematic reviews 20100101

Title: A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting.

Journal: Annals of general psychiatry 20100101

Title: Olanzapine approved for the acute treatment of schizophrenia or manic/mixed episodes associated with bipolar I disorder in adolescent patients.

Journal: Neuropsychiatric disease and treatment 20100101

Title: An overview of Indian research in schizophrenia.

Journal: Indian journal of psychiatry 20100101

Title: The association between class of antipsychotic and rates of hospitalization: results of a retrospective analysis of data from the 2005 Medicare current beneficiary survey.

Journal: Clinical therapeutics 20091201

Title: Psychotic woman with painful abdominal distension. Life-threatening psychotropic drug-induced gastrointestinal hypomotility.

Journal: Annals of emergency medicine 20091101

Title: Use and safety of antipsychotic drugs during pregnancy.

Journal: Journal of psychiatric practice 20090501

Title: Finding my faith.

Journal: Indian journal of psychiatry 20090101

Title: Bacitracin-sensitive aminopeptidase(s) degradation of methionine(5)-enkephalin by human brain putamen and hippocampus preparations: inhibition by phenothiazine drugs.

Journal: American journal of therapeutics 20090101

Title: Rapid liquid chromatography/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (norclozapine) in human serum.

Journal: Journal of clinical laboratory analysis 20090101

Title: Current perspectives in the treatment of resistant schizophrenia.

Journal: Indian journal of psychiatry 20090101

Title: Spectroscopic and electrochemical analysis of psychotropic drugs.

Journal: Indian journal of pharmaceutical sciences 20090101

Title: Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia.

Journal: Indian journal of psychiatry 20090101

Title: Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-compulsive symptoms in schizophrenia.

Journal: Indian journal of psychological medicine 20090101

Title: Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients.

Journal: The American journal of geriatric pharmacotherapy 20081001

Title: HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis 20080805

Title: Analysis of the recent antipsychotic aripiprazole in human plasma by capillary electrophoresis and high-performance liquid chromatography with diode array detection.

Journal: Analytica chimica acta 20080407

Title: Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia.

Journal: Schizophrenia bulletin 20080101

Title: Incorporating clinical guidelines through clinician decision-making.

Journal: Implementation science : IS 20080101

Title: The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).

Journal: BMC psychiatry 20080101

Title: Modifications of antiepileptic drugs for improved tolerability and efficacy.

Journal: Perspectives in medicinal chemistry 20080101

Title: Loxapine for schizophrenia.

Journal: The Cochrane database of systematic reviews 20071017

Title: Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography.

Journal: Drug development and industrial pharmacy 20071001

Title: Pharmacological causes of hyperprolactinemia.

Journal: Therapeutics and clinical risk management 20071001

Title: HPLC analysis of the novel antidepressant duloxetine in human plasma after an original solid-phase extraction procedure.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901

Title: Simultaneous analysis of classical neuroleptics, atypical antipsychotics and their metabolites in human plasma.

Journal: Analytical and bioanalytical chemistry 20070501

Title: Risk of extrapyramidal syndrome in schizophrenic patients treated with antipsychotics: a population-based study.

Journal: Clinical pharmacology and therapeutics 20070401

Title: Simultaneous determination of methadone, buprenorphine and norbuprenorphine in biological fluids for therapeutic drug monitoring purposes.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

Title: Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20070227

Title: Simultaneous determination of the antipsychotic drugs levomepromazine and clozapine and their main metabolites in human plasma by a HPLC-UV method with solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070201

Title: Correlations between weight changes and lipid profile changes in schizophrenic patients after antipsychotics therapy.

Journal: Chang Gung medical journal 20070101

Title: Effect of loxapine on electrical brain activity, intracranial pressure, and middle cerebral artery flow velocity in traumatic brain-injured patients.

Journal: Neurocritical care 20070101

Title: Clozapine: Current perspective.

Journal: Indian journal of psychiatry 20070101

Title: Lack of enhanced effect of antipsychotics combined with fluvoxamine on acetylcholine release in rat prefrontal cortex.

Journal: Journal of pharmacological sciences 20061201

Title: Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides.

Journal: European journal of medicinal chemistry 20061101

Title: Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients.

Journal: The Annals of pharmacotherapy 20061101

Title: Loxapine treatment in an autistic child with aggressive behavior: therapeutic challenges.

Journal: Journal of child and adolescent psychopharmacology 20061001

Title: Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review.

Journal: The Journal of clinical psychiatry 20060901

Title: Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.

Journal: Journal of medicinal chemistry 20060727

Title: [Efficacy and adverse reactions of antipsychotics for neuropsychiatric symptoms in dementia: a systematic review].

Journal: Nederlands tijdschrift voor geneeskunde 20060715

Title: Adjunctive topiramate in ultradian cycling bipolar disorder: case report with 3-year follow-up.

Journal: European psychiatry : the journal of the Association of European Psychiatrists 20060601

Title: Increasing psychosis in a patient switched from clozaril to generic clozapine.

Journal: The American journal of psychiatry 20060401

Title: Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia.

Journal: BMC psychiatry 20060101

Title: [Clinical and socio-demographic profile of patients with schizophrenia according to the antipsychotic treatment prescribed].

Journal: L'Encephale 20060101

Title: [Therapeutics approach of adult patients with acute and chronic psychotic states: REALITE survey].

Journal: L'Encephale 20060101

Title: NMS after clozapine initiation.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry 20051101

Title: Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicality.

Journal: Schizophrenia research 20050915

Title: Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.

Journal: Psychopharmacology 20050501

Title: Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.

Journal: Journal of medicinal chemistry 20050324

Title: Minimally effective doses of conventional antipsychotic medications used to treat aggression, self-injurious and destructive behaviors in mentally retarded adults.

Journal: Journal of clinical psychopharmacology 20050201

Title: Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor.

Journal: European journal of medicinal chemistry 20050201

Title: Treatment of acute mania--from clinical trials to recommendations for clinical practice.

Journal: Human psychopharmacology 20050101

Title: Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050101

Title: Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors.

Journal: European journal of pharmacology 20040714

Title: Transient hyperproinsulinemia during treatment with clozapine and amisulpride.

Journal: The Journal of clinical psychiatry 20040601

Title: Treatment-refractory schizophrenia.

Journal: Dialogues in clinical neuroscience 20040301

Title: Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.

Journal: Journal of medicinal chemistry 20040101

Title: An assessment of quality of sleep and the use of drugs with sedating properties in hospitalized adult patients.

Journal: Health and quality of life outcomes 20040101

Title: [Agranulocytosis induced by loxapine in an elderly patient: a case study].

Journal: Therapie 20040101

Title: Simultaneous determination of four antipsychotic drugs in plasma by high-performance liquid chromatography. Application to management of acute intoxications.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20031005

Title: Effects of some antidepressant drugs on tryptaminergic responses of the rat jejunum.

Journal: Pharmacology 20031001

Title: Neuroleptic malignant syndrome: case report and discussion.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20030902

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry 20030703

Title: Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex.

Journal: Synapse (New York, N.Y.) 20030501

Title: A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens.

Journal: Psychopharmacology 20030501

Title: Induction of hyperglycemia in mice with atypical antipsychotic drugs that inhibit glucose uptake.

Journal: Pharmacology, biochemistry, and behavior 20030501

Title: H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030301

Title: Human genetic variations in the 5HT2A receptor: a single nucleotide polymorphism identified with altered response to clozapine.

Journal: Pharmacogenetics 20030201

Title: In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure.

Journal: Pharmacology 20030101

Title: Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia.

Journal: Journal of psychiatry & neuroscience : JPN 20030101

Title: JL 13, an atypical antipsychotic: a preclinical review.

Journal: CNS drug reviews 20030101

Title: Loxapine versus olanzapine in the treatment of delirium following traumatic brain injury.

Journal: NeuroRehabilitation 20030101

Title: [Survey of management methods for patients in a state of agitation at admission and emergency departments in France].

Journal: L'Encephale 20030101

Title: Interspecies variability and drug interactions of loxapine metabolism in liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics 20030101

Title: Discriminative stimulus properties in rats of the novel antipsychotic quetiapine.

Journal: Experimental and clinical psychopharmacology 20021101

Title: Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.

Journal: Acta crystallographica. Section D, Biological crystallography 20020601

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation.

Journal: Archives of general psychiatry 20020401

Title: [Self-poisoning with Datura stramonium. 3 case reports].

Journal: Presse medicale (Paris, France : 1983) 20020119

Title: Current practices in managing acutely disturbed patients at three hospitals in Rio de Janeiro-Brazil: a prevalence study.

Journal: BMC psychiatry 20020101

Title: TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].

Journal: BMC psychiatry 20020101

Title: Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine.

Journal: Brain research 20011227

Title: A new class of antiarrhythmic-defibrillatory agents.

Journal: Bioorganic & medicinal chemistry letters 20011119

Title: Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.

Journal: The Journal of pharmacology and experimental therapeutics 20011001

Title: Treatment of the special patient with schizophrenia.

Journal: Dialogues in clinical neuroscience 20010601

Title: Re: Neuroleptic malignant syndrome associated with quetiapine.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie 20010501

Title: Loxapine side-effects: 3 case reports of hyperleukocytosis.

Journal: Therapie 20010101

Title: Clinically significant drug interactions with agents specific for migraine attacks.

Journal: CNS drugs 20010101

Title: [Body weight changes and psychotropic drug treatment: neuroleptics].

Journal: L'Encephale 20010101

Title: Thioridazine for dementia.

Journal: The Cochrane database of systematic reviews 20010101

Title: [Psychiatric manifestations of lupus erythematosus systemic and Sjogren's syndrome].

Journal: L'Encephale 20010101

Title: Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

Journal: The Journal of pharmacology and experimental therapeutics 20001001

Title: Olanzapine-induced tardive dystonia.

Journal: The American journal of psychiatry 19991001

Title: Does loxapine have 'atypical' properties? Clinical evidence.

Journal: The Journal of clinical psychiatry 19990101

Title: The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat.

Journal: British journal of pharmacology 19980801

Title: Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 19970301

Title: Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19970201

Title: Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.

Journal: Journal of neurochemistry 19960101

Title: Emergence of symptoms of Tourette's syndrome during fluvoxamine treatment of obsessive-compulsive disorder.

Journal: The British journal of psychiatry : the journal of mental science 19940601

Title: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Journal: The Journal of pharmacology and experimental therapeutics 19940301

Title: Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

Journal: The Journal of biological chemistry 19930825

Title: Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists.

Journal: Journal of medicinal chemistry 19930723

Title: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

Journal: Molecular pharmacology 19930301

Title: Simultaneous quantitation of loxapine, amoxapine and their 7- and 8-hydroxy metabolites in plasma by high-performance liquid chromatography.

Journal: Journal of chromatography 19910308

Title: Loxapine-lorazepam-induced hypotension and stupor.

Journal: Journal of clinical psychopharmacology 19890601

Title: Neurotoxicity resulting from a combination of lithium and loxapine.

Journal: The Journal of clinical psychiatry 19890501

Title: Neurotoxicity induced by combined lithium-thioridazine treatment.

Journal: Biological psychiatry 19860701

Title: Rapid tranquilization: a comparison of thiothixene with loxapine.

Journal: The Journal of clinical psychiatry 19860601

Title: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

Journal: Proceedings of the National Academy of Sciences of the United States of America 19840901

Title: Drug interactions on spontaneous locomotor activity in rats. Neuroleptics and amphetamine-induced hyperactivity.

Journal: Neuropharmacology 19840801

Title: Loxapine versus chlorpromazine in paranoid schizophrenia: a double-blind study.

Journal: The Journal of clinical psychiatry 19840401

Title: Neuroleptic-induced catatonia: case report.

Journal: The Journal of clinical psychiatry 19830801

Title: Neuroleptic malignant syndrome associated with loxapine.

Journal: The Journal of clinical psychiatry 19830101

Title: Efficacy of antipsychotic medications in behaviorally disturbed dementia patients.

Journal: The American journal of psychiatry 19820901

Title: Sexual dysfunction in women using major tranquilizers.

Journal: Psychosomatics 19820901

Title: Loxapine succinate as initial treatment of hostile and aggressive schizophrenic criminal offenders.

Journal: Journal of clinical pharmacology 19820101

Title: Seizures induced by acute loxapine overdose.

Journal: The American journal of psychiatry 19810801

Title: Evaluations of loxapine succinate in the ambulatory treatment of acute schizophrenic episodes.

Journal: International pharmacopsychiatry 19800101

Title: [Loxapine succinate: a new neuroleptic].

Journal: L'Encephale 19790101

Title: A two year trial of loxapine succinate in chronic psychotic patients.

Journal: Diseases of the nervous system 19760501

Title: Treatment of acute psychotic patients with loxapine parenterally.

Journal: Current therapeutic research, clinical and experimental 19760201

Title: [The assessment of neuroleptogenic extrapyramidal syndroms in psychopharmacological research (author's transl)].

Journal: Pharmakopsychiatrie, Neuro-Psychopharmakologie 19750101

Title: Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35.

Title: Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30.

Title: Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85.

Title: Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4.

Title: Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013 Jun;27(6):479-89.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Tags:1977-10-2 Molecular Formula|1977-10-2 MDL|1977-10-2 SMILES|1977-10-2 Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
Catalog No.: AA002AW1
1977-10-2,MFCD00242836
1977-10-2 | Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
Pack Size: 100mg
Purity: 10mM in DMSO
in stock
$206.00 $144.00
Pack Size: 500mg
Purity: 10mM in DMSO
in stock
$566.00 $397.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA002AW1
Chemical Name: Dibenz[b,f][1,4]oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-
CAS Number: 1977-10-2
Molecular Formula: C18H18ClN3O
Molecular Weight: 327.8080
MDL Number: MFCD00242836
SMILES: CN1CCN(CC1)C1=Nc2ccccc2Oc2c1cc(Cl)cc2
Properties
Complexity: 450  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 0  
Isotope Atom Count: 0  
Rotatable Bond Count: 1  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.1  
Literature fold

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology20171201

Title: [Dysphagia or dysphagias during neuroleptic medication?].

Journal: L'Encephale20120901

Title: The psychopharmacology of aggressive behavior: a translational approach: part 2: clinical studies using atypical antipsychotics, anticonvulsants, and lithium.

Journal: Journal of clinical psychopharmacology20120401

Title: The antipsychotic drug loxapine is an opener of the sodium-activated potassium channel slack (Slo2.2).

Journal: The Journal of pharmacology and experimental therapeutics20120301

Title: Inhaled loxapine for agitation revisited: focus on effect sizes from 2 Phase III randomised controlled trials in persons with schizophrenia or bipolar disorder.

Journal: International journal of clinical practice20120301

Title: Loxapine P-glycoprotein interactions in vitro.

Journal: Drug metabolism letters20120301

Title: New pyridobenzoxazepine derivatives derived from 5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine (JL13): chemical synthesis and pharmacological evaluation.

Journal: Journal of medicinal chemistry20120223

Title: Rapid acute treatment of agitation in patients with bipolar I disorder: a multicenter, randomized, placebo-controlled clinical trial with inhaled loxapine.

Journal: Bipolar disorders20120201

Title: [RÉALITÉ LT, a pharmacoepidemiological study of semiology and therapeutic strategy of patients with schizophrenia treated by antipsychotic loxapine in routine clinical practice].

Journal: L'Encephale20120201

Title: The oxidative degradation of dibenzoazepine derivatives by cerium(IV) complexes in acidic sulfate media.

Journal: Dalton transactions (Cambridge, England : 2003)20120128

Title: Investigation of the disposition of loxapine, amoxapine and their hydroxylated metabolites in different brain regions, CSF and plasma of rat by LC-MS/MS.

Journal: Journal of pharmaceutical and biomedical analysis20120125

Title: Modeling psychiatric disorders through reprogramming.

Journal: Disease models & mechanisms20120101

Title: Now take a deep breath: inhaled loxapine for the treatment of acute agitation.

Journal: Journal of psychosocial nursing and mental health services20120101

Title: The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease.

Journal: Parkinson's disease20120101

Title: Differential risk of death in older residents in nursing homes prescribed specific antipsychotic drugs: population based cohort study.

Journal: BMJ (Clinical research ed.)20120101

Title: Heart rate-corrected QT interval helps predict mortality after intentional organophosphate poisoning.

Journal: PloS one20120101

Title: Palladium-catalyzed reaction of aryl iodides with ortho-bromoanilines and norbornene/norbornadiene: unexpected formation of dibenzoazepine derivatives.

Journal: Angewandte Chemie (International ed. in English)20111216

Title: Neuroleptic malignant syndrome-like reaction precipitated by antipsychotics in a patient with gamma-butyrolactone withdrawal.

Journal: Journal of addiction medicine20111201

Title: Swallowing difficulties: a prognostic signpost.

Journal: Canadian family physician Medecin de famille canadien20111201

Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

Journal: PLoS computational biology20111201

Title: Efficacy and safety of loxapine for inhalation in the treatment of agitation in patients with schizophrenia: a randomized, double-blind, placebo-controlled trial.

Journal: The Journal of clinical psychiatry20111001

Title: In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine.

Journal: Biopharmaceutics & drug disposition20111001

Title: The pharmacoepidemiology of antipsychotics for adults with schizophrenia in Canada, 2005 to 2009.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie20111001

Title: 'Extended' antipsychotic dosing in the maintenance treatment of schizophrenia: a double-blind, placebo-controlled trial.

Journal: The Journal of clinical psychiatry20110801

Title: Inhaled loxapine reduces acute agitation in people with schizophrenia compared with placebo.

Journal: Evidence-based mental health20110801

Title: New uses for old drugs: pharmacophore-based screening for the discovery of P-glycoprotein inhibitors.

Journal: Chemical biology & drug design20110701

Title: Combination loxapine and aripiprazole for refractory hallucinations in schizophrenia.

Journal: The Annals of pharmacotherapy20110701

Title: Quality of life after electroconvulsive therapy in persons with treatment resistant schizophrenia.

Journal: The Indian journal of medical research20110601

Title: The dopaminergic system in peripheral blood lymphocytes: from physiology to pharmacology and potential applications to neuropsychiatric disorders.

Journal: Current neuropharmacology20110601

Title: Modelling schizophrenia using human induced pluripotent stem cells.

Journal: Nature20110512

Title: The benefits of an active control arm.

Journal: The British journal of psychiatry : the journal of mental science20110401

Title: Aerosolised antipsychotic assuages agitation: inhaled loxapine for agitation associated with schizophrenia or bipolar disorder.

Journal: International journal of clinical practice20110301

Title: Interaction of clozapine and its nitrenium ion with rat D2 dopamine receptors: in vitro binding and computational study.

Journal: Journal of computer-aided molecular design20110201

Title: In vitro aerosol characterization of Staccato(®) Loxapine.

Journal: International journal of pharmaceutics20110117

Title: Rapid acute treatment of agitation in individuals with schizophrenia: multicentre, randomised, placebo-controlled study of inhaled loxapine.

Journal: The British journal of psychiatry : the journal of mental science20110101

Title: Meeting on big mutations addresses big questions in human genetics.

Journal: Genome medicine20110101

Title: Pharmacotherapy for treatment-resistant schizophrenia.

Journal: Neuropsychiatric disease and treatment20110101

Title: Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report.

Journal: Child and adolescent psychiatry and mental health20110101

Title: Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways.

Journal: PloS one20110101

Title: Homicide and associated steroid acute psychosis: a case report.

Journal: Case reports in medicine20110101

Title: Validation of HPLC-MS/MS methods for analysis of loxapine, amoxapine, 7-OH-loxapine, 8-OH-loxapine and loxapine N-oxide in human plasma.

Journal: Bioanalysis20101201

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research20101201

Title: In vitro aerosol deposition in the oropharyngeal region for Staccato loxapine.

Journal: Journal of aerosol medicine and pulmonary drug delivery20100801

Title: 4-Nitro-2-phenoxy-aniline.

Journal: Acta crystallographica. Section E, Structure reports online20100601

Title: Pharmacokinetics of loxapine following inhalation of a thermally generated aerosol in healthy volunteers.

Journal: Journal of clinical pharmacology20100201

Title: [Catatonia in a 14 year-old girl: treatment with clorazepam and carbamazepine, a 10-year follow-up].

Journal: L'Encephale20100201

Title: Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28.

Journal: Bioorganic & medicinal chemistry20100115

Title: Simultaneous HPLC determination of 14 tricyclic antidepressants and metabolites in human plasma.

Journal: Journal of separation science20100101

Title: Identifying unexpected therapeutic targets via chemical-protein interactome.

Journal: PloS one20100101

Title: Beneficial effects of loxapine on agitation and breathing patterns during weaning from mechanical ventilation.

Journal: Critical care (London, England)20100101

Title: Chem2Bio2RDF: a semantic framework for linking and data mining chemogenomic and systems chemical biology data.

Journal: BMC bioinformatics20100101

Title: Pharmacological interventions for borderline personality disorder.

Journal: The Cochrane database of systematic reviews20100101

Title: A 64-week, multicenter, open-label study of aripiprazole effectiveness in the management of patients with schizophrenia or schizoaffective disorder in a general psychiatric outpatient setting.

Journal: Annals of general psychiatry20100101

Title: Olanzapine approved for the acute treatment of schizophrenia or manic/mixed episodes associated with bipolar I disorder in adolescent patients.

Journal: Neuropsychiatric disease and treatment20100101

Title: An overview of Indian research in schizophrenia.

Journal: Indian journal of psychiatry20100101

Title: The association between class of antipsychotic and rates of hospitalization: results of a retrospective analysis of data from the 2005 Medicare current beneficiary survey.

Journal: Clinical therapeutics20091201

Title: Psychotic woman with painful abdominal distension. Life-threatening psychotropic drug-induced gastrointestinal hypomotility.

Journal: Annals of emergency medicine20091101

Title: Use and safety of antipsychotic drugs during pregnancy.

Journal: Journal of psychiatric practice20090501

Title: Finding my faith.

Journal: Indian journal of psychiatry20090101

Title: Bacitracin-sensitive aminopeptidase(s) degradation of methionine(5)-enkephalin by human brain putamen and hippocampus preparations: inhibition by phenothiazine drugs.

Journal: American journal of therapeutics20090101

Title: Rapid liquid chromatography/tandem mass spectrometer (LCMS) method for clozapine and its metabolite N-desmethyl clozapine (norclozapine) in human serum.

Journal: Journal of clinical laboratory analysis20090101

Title: Current perspectives in the treatment of resistant schizophrenia.

Journal: Indian journal of psychiatry20090101

Title: Spectroscopic and electrochemical analysis of psychotropic drugs.

Journal: Indian journal of pharmaceutical sciences20090101

Title: Safety and efficacy of antipsychotic drugs for the behavioral and psychological symptoms of dementia.

Journal: Indian journal of psychiatry20090101

Title: Neuroanatomical, neurochemical, and neurodevelopmental basis of obsessive-compulsive symptoms in schizophrenia.

Journal: Indian journal of psychological medicine20090101

Title: Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients.

Journal: The American journal of geriatric pharmacotherapy20081001

Title: HPLC analysis of the antidepressant trazodone and its main metabolite m-CPP in human plasma.

Journal: Journal of pharmaceutical and biomedical analysis20080805

Title: Analysis of the recent antipsychotic aripiprazole in human plasma by capillary electrophoresis and high-performance liquid chromatography with diode array detection.

Journal: Analytica chimica acta20080407

Title: Efficacy and tolerability of second-generation antipsychotics in children and adolescents with schizophrenia.

Journal: Schizophrenia bulletin20080101

Title: Incorporating clinical guidelines through clinician decision-making.

Journal: Implementation science : IS20080101

Title: The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).

Journal: BMC psychiatry20080101

Title: Modifications of antiepileptic drugs for improved tolerability and efficacy.

Journal: Perspectives in medicinal chemistry20080101

Title: Loxapine for schizophrenia.

Journal: The Cochrane database of systematic reviews20071017

Title: Determination of clozapine and its metabolite, norclozapine in various biological matrices using high-performance liquid chromatography.

Journal: Drug development and industrial pharmacy20071001

Title: Pharmacological causes of hyperprolactinemia.

Journal: Therapeutics and clinical risk management20071001

Title: HPLC analysis of the novel antidepressant duloxetine in human plasma after an original solid-phase extraction procedure.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070901

Title: Simultaneous analysis of classical neuroleptics, atypical antipsychotics and their metabolites in human plasma.

Journal: Analytical and bioanalytical chemistry20070501

Title: Risk of extrapyramidal syndrome in schizophrenic patients treated with antipsychotics: a population-based study.

Journal: Clinical pharmacology and therapeutics20070401

Title: Simultaneous determination of methadone, buprenorphine and norbuprenorphine in biological fluids for therapeutic drug monitoring purposes.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070301

Title: Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne20070227

Title: Simultaneous determination of the antipsychotic drugs levomepromazine and clozapine and their main metabolites in human plasma by a HPLC-UV method with solid-phase extraction.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20070201

Title: Correlations between weight changes and lipid profile changes in schizophrenic patients after antipsychotics therapy.

Journal: Chang Gung medical journal20070101

Title: Effect of loxapine on electrical brain activity, intracranial pressure, and middle cerebral artery flow velocity in traumatic brain-injured patients.

Journal: Neurocritical care20070101

Title: Clozapine: Current perspective.

Journal: Indian journal of psychiatry20070101

Title: Lack of enhanced effect of antipsychotics combined with fluvoxamine on acetylcholine release in rat prefrontal cortex.

Journal: Journal of pharmacological sciences20061201

Title: Synthesis, characterization, antimicrobial and single crystal X-ray crystallographic studies of some new sulfonyl, 4-chloro phenoxy benzene and dibenzoazepine substituted benzamides.

Journal: European journal of medicinal chemistry20061101

Title: Systematic review of antipsychotics for the treatment of hospital-associated delirium in medically or surgically ill patients.

Journal: The Annals of pharmacotherapy20061101

Title: Loxapine treatment in an autistic child with aggressive behavior: therapeutic challenges.

Journal: Journal of child and adolescent psychopharmacology20061001

Title: Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review.

Journal: The Journal of clinical psychiatry20060901

Title: Characterization of the histamine H4 receptor binding site. Part 1. Synthesis and pharmacological evaluation of dibenzodiazepine derivatives.

Journal: Journal of medicinal chemistry20060727

Title: [Efficacy and adverse reactions of antipsychotics for neuropsychiatric symptoms in dementia: a systematic review].

Journal: Nederlands tijdschrift voor geneeskunde20060715

Title: Adjunctive topiramate in ultradian cycling bipolar disorder: case report with 3-year follow-up.

Journal: European psychiatry : the journal of the Association of European Psychiatrists20060601

Title: Increasing psychosis in a patient switched from clozaril to generic clozapine.

Journal: The American journal of psychiatry20060401

Title: Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophrenia.

Journal: BMC psychiatry20060101

Title: [Clinical and socio-demographic profile of patients with schizophrenia according to the antipsychotic treatment prescribed].

Journal: L'Encephale20060101

Title: [Therapeutics approach of adult patients with acute and chronic psychotic states: REALITE survey].

Journal: L'Encephale20060101

Title: NMS after clozapine initiation.

Journal: Journal of the American Academy of Child and Adolescent Psychiatry20051101

Title: Contrasting loxapine to its isomer isoloxapine--the critical role of in vivo D2 blockade in determining atypicality.

Journal: Schizophrenia research20050915

Title: Stable expression of constitutively activated mutant h5HT6 and h5HT7 serotonin receptors: inverse agonist activity of antipsychotic drugs.

Journal: Psychopharmacology20050501

Title: Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.

Journal: Journal of medicinal chemistry20050324

Title: Minimally effective doses of conventional antipsychotic medications used to treat aggression, self-injurious and destructive behaviors in mentally retarded adults.

Journal: Journal of clinical psychopharmacology20050201

Title: Atypical and typical antipsychotic drug interactions with the dopamine D2 receptor.

Journal: European journal of medicinal chemistry20050201

Title: Treatment of acute mania--from clinical trials to recommendations for clinical practice.

Journal: Human psychopharmacology20050101

Title: Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology20050101

Title: Differential inverse agonist efficacies of SB-258719, SB-258741 and SB-269970 at human recombinant serotonin 5-HT7 receptors.

Journal: European journal of pharmacology20040714

Title: Transient hyperproinsulinemia during treatment with clozapine and amisulpride.

Journal: The Journal of clinical psychiatry20040601

Title: Treatment-refractory schizophrenia.

Journal: Dialogues in clinical neuroscience20040301

Title: Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents.

Journal: Journal of medicinal chemistry20040101

Title: An assessment of quality of sleep and the use of drugs with sedating properties in hospitalized adult patients.

Journal: Health and quality of life outcomes20040101

Title: [Agranulocytosis induced by loxapine in an elderly patient: a case study].

Journal: Therapie20040101

Title: Simultaneous determination of four antipsychotic drugs in plasma by high-performance liquid chromatography. Application to management of acute intoxications.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences20031005

Title: Effects of some antidepressant drugs on tryptaminergic responses of the rat jejunum.

Journal: Pharmacology20031001

Title: Neuroleptic malignant syndrome: case report and discussion.

Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne20030902

Title: Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7).

Journal: Journal of medicinal chemistry20030703

Title: Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex.

Journal: Synapse (New York, N.Y.)20030501

Title: A comparison of the effects of loxapine with ziprasidone and thioridazine on the release of dopamine and acetylcholine in the prefrontal cortex and nucleus accumbens.

Journal: Psychopharmacology20030501

Title: Induction of hyperglycemia in mice with atypical antipsychotic drugs that inhibit glucose uptake.

Journal: Pharmacology, biochemistry, and behavior20030501

Title: H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology20030301

Title: Human genetic variations in the 5HT2A receptor: a single nucleotide polymorphism identified with altered response to clozapine.

Journal: Pharmacogenetics20030201

Title: In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure.

Journal: Pharmacology20030101

Title: Effect of loxapine on peripheral dopamine-like and serotonin receptors in patients with schizophrenia.

Journal: Journal of psychiatry & neuroscience : JPN20030101

Title: JL 13, an atypical antipsychotic: a preclinical review.

Journal: CNS drug reviews20030101

Title: Loxapine versus olanzapine in the treatment of delirium following traumatic brain injury.

Journal: NeuroRehabilitation20030101

Title: [Survey of management methods for patients in a state of agitation at admission and emergency departments in France].

Journal: L'Encephale20030101

Title: Interspecies variability and drug interactions of loxapine metabolism in liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics20030101

Title: Discriminative stimulus properties in rats of the novel antipsychotic quetiapine.

Journal: Experimental and clinical psychopharmacology20021101

Title: Structure-based enzyme inhibitor design: modeling studies and crystal structure analysis of Pneumocystis carinii dihydrofolate reductase ternary complex with PT653 and NADPH.

Journal: Acta crystallographica. Section D, Biological crystallography20020601

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Evidence for impaired cortical inhibition in schizophrenia using transcranial magnetic stimulation.

Journal: Archives of general psychiatry20020401

Title: [Self-poisoning with Datura stramonium. 3 case reports].

Journal: Presse medicale (Paris, France : 1983)20020119

Title: Current practices in managing acutely disturbed patients at three hospitals in Rio de Janeiro-Brazil: a prevalence study.

Journal: BMC psychiatry20020101

Title: TREC-Rio trial: a randomised controlled trial for rapid tranquillisation for agitated patients in emergency psychiatric rooms [ISRCTN44153243].

Journal: BMC psychiatry20020101

Title: Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine.

Journal: Brain research20011227

Title: A new class of antiarrhythmic-defibrillatory agents.

Journal: Bioorganic & medicinal chemistry letters20011119

Title: Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor.

Journal: The Journal of pharmacology and experimental therapeutics20011001

Title: Treatment of the special patient with schizophrenia.

Journal: Dialogues in clinical neuroscience20010601

Title: Re: Neuroleptic malignant syndrome associated with quetiapine.

Journal: Canadian journal of psychiatry. Revue canadienne de psychiatrie20010501

Title: Loxapine side-effects: 3 case reports of hyperleukocytosis.

Journal: Therapie20010101

Title: Clinically significant drug interactions with agents specific for migraine attacks.

Journal: CNS drugs20010101

Title: [Body weight changes and psychotropic drug treatment: neuroleptics].

Journal: L'Encephale20010101

Title: Thioridazine for dementia.

Journal: The Cochrane database of systematic reviews20010101

Title: [Psychiatric manifestations of lupus erythematosus systemic and Sjogren's syndrome].

Journal: L'Encephale20010101

Title: Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.

Journal: The Journal of pharmacology and experimental therapeutics20001001

Title: Olanzapine-induced tardive dystonia.

Journal: The American journal of psychiatry19991001

Title: Does loxapine have 'atypical' properties? Clinical evidence.

Journal: The Journal of clinical psychiatry19990101

Title: The role of alpha2-adrenoceptor antagonism in the anti-cataleptic properties of the atypical neuroleptic agent, clozapine, in the rat.

Journal: British journal of pharmacology19980801

Title: Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats.

Journal: Naunyn-Schmiedeberg's archives of pharmacology19970301

Title: Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology19970201

Title: Cloning, characterization, and chromosomal localization of a human 5-HT6 serotonin receptor.

Journal: Journal of neurochemistry19960101

Title: Emergence of symptoms of Tourette's syndrome during fluvoxamine treatment of obsessive-compulsive disorder.

Journal: The British journal of psychiatry : the journal of mental science19940601

Title: Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors.

Journal: The Journal of pharmacology and experimental therapeutics19940301

Title: Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype.

Journal: The Journal of biological chemistry19930825

Title: Biologically active conformers of phenothiazines and thioxanthenes. Further evidence for a ligand model of dopamine D2 receptor antagonists.

Journal: Journal of medicinal chemistry19930723

Title: Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs.

Journal: Molecular pharmacology19930301

Title: Simultaneous quantitation of loxapine, amoxapine and their 7- and 8-hydroxy metabolites in plasma by high-performance liquid chromatography.

Journal: Journal of chromatography19910308

Title: Loxapine-lorazepam-induced hypotension and stupor.

Journal: Journal of clinical psychopharmacology19890601

Title: Neurotoxicity resulting from a combination of lithium and loxapine.

Journal: The Journal of clinical psychiatry19890501

Title: Neurotoxicity induced by combined lithium-thioridazine treatment.

Journal: Biological psychiatry19860701

Title: Rapid tranquilization: a comparison of thiothixene with loxapine.

Journal: The Journal of clinical psychiatry19860601

Title: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.

Journal: Proceedings of the National Academy of Sciences of the United States of America19840901

Title: Drug interactions on spontaneous locomotor activity in rats. Neuroleptics and amphetamine-induced hyperactivity.

Journal: Neuropharmacology19840801

Title: Loxapine versus chlorpromazine in paranoid schizophrenia: a double-blind study.

Journal: The Journal of clinical psychiatry19840401

Title: Neuroleptic-induced catatonia: case report.

Journal: The Journal of clinical psychiatry19830801

Title: Neuroleptic malignant syndrome associated with loxapine.

Journal: The Journal of clinical psychiatry19830101

Title: Efficacy of antipsychotic medications in behaviorally disturbed dementia patients.

Journal: The American journal of psychiatry19820901

Title: Sexual dysfunction in women using major tranquilizers.

Journal: Psychosomatics19820901

Title: Loxapine succinate as initial treatment of hostile and aggressive schizophrenic criminal offenders.

Journal: Journal of clinical pharmacology19820101

Title: Seizures induced by acute loxapine overdose.

Journal: The American journal of psychiatry19810801

Title: Evaluations of loxapine succinate in the ambulatory treatment of acute schizophrenic episodes.

Journal: International pharmacopsychiatry19800101

Title: [Loxapine succinate: a new neuroleptic].

Journal: L'Encephale19790101

Title: A two year trial of loxapine succinate in chronic psychotic patients.

Journal: Diseases of the nervous system19760501

Title: Treatment of acute psychotic patients with loxapine parenterally.

Journal: Current therapeutic research, clinical and experimental19760201

Title: [The assessment of neuroleptogenic extrapyramidal syndroms in psychopharmacological research (author's transl)].

Journal: Pharmakopsychiatrie, Neuro-Psychopharmakologie19750101

Title: Singh AN, et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci. 1996 Jan;21(1):29-35.

Title: Labuzek K, et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol. 2005 Jan;15(1):23-30.

Title: Lee T, et al. Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res. 1984 Aug;12(4):277-85.

Title: Kalkman HO, et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol. 1997 Mar;355(3):361-4.

Title: Keating GM. Loxapine inhalation powder: a review of its use in the acute treatment of agitation in patients with bipolar disorder or schizophrenia. CNS Drugs. 2013 Jun;27(6):479-89.

Building Blocks More >
19810-79-8
19810-79-8
2-Morpholin-4-yl-pyrimidin-4-ol
AA002B8G | MFCD00234443
198474-90-7
198474-90-7
Boc-L-3,4-difluorophenylalanine
AA002BH3 | MFCD00672518
1989-33-9
1989-33-9
Fluorene-9-carboxylic acid
AA002BQ8 | MFCD00001136
19887-32-2
19887-32-2
N-Ethoxycarbonyl-l-phenylalanine
AA002BPG | MFCD00239447
199850-56-1
199850-56-1
Methyl 2-amino-4-chloro-5-iodobenzoate
AA002CAZ | MFCD11977364
200295-57-4
200295-57-4
4-Nitrobenzene-1,3-diamine sulfate
AA002CKT | MFCD08460157
2007920-54-7
2007920-54-7
tert-Butyl-3-amino-2-methylazetidine-1-carboxylate,cis-
AA002CXQ | MFCD20922035
201274-07-9
201274-07-9
H-Thr-obzl oxalate
AA002D8D | MFCD02259509
2017-87-0
2017-87-0
Ethyl 2-cyano-3-(4-methoxyphenyl)acrylate
AA002DI5 | MFCD00026849
189950-66-1
189950-66-1
Ac-devd-pna
AA002E3X | MFCD00792707
Submit
© 2017 AA BLOCKS, INC. All rights reserved.