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212370-59-7,MFCD02179659
Catalog No.:AA00BDPO

212370-59-7 | HS024

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
100%
1 week  
$453.00   $317.00
- +
5mg
100%
1 week  
$1,012.00   $708.00
- +
10mg
100%
1 week  
$1,372.00   $960.00
- +
25mg
100%
1 week  
$1,989.00   $1,392.00
- +
50mg
100%
1 week  
$2,675.00   $1,872.00
- +
100mg
100%
1 week  
$3,623.00   $2,536.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BDPO
Chemical Name:
HS024
CAS Number:
212370-59-7
Molecular Formula:
C58H79N19O10S2
Molecular Weight:
1266.4992
MDL Number:
MFCD02179659
SMILES:
CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCNC(=N)N)Cc1c[nH]cn1)Cc1ccc2c(c1)cccc2)CCCNC(=N)N)Cc1c[nH]c2c1cccc2)C(=O)N)NC(=O)C
Properties
Computed Properties
 
Complexity:
2470  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
89  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
16  
Isotope Atom Count:
0  
Rotatable Bond Count:
19  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.5  

Literature

Title: Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway.

Journal: Molecular and cellular endocrinology 20120102

Title: Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes.

Journal: BMC evolutionary biology 20070101

Title: Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling.

Journal: Journal of neuroimmunology 20051201

Title: Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats.

Journal: Neuroendocrinology 20040101

Title: Molecular cloning, pharmacological characterization, and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake.

Journal: Endocrinology 20030601

Title: Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats.

Journal: The Journal of endocrinology 20020601

Title: Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.

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SDS
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Tags:212370-59-7 Molecular Formula|212370-59-7 MDL|212370-59-7 SMILES|212370-59-7 HS024
Catalog No.: AA00BDPO
212370-59-7,MFCD02179659
212370-59-7 | HS024
Pack Size： 1mg
Purity： 100%
1 week
$453.00 $317.00
Pack Size： 5mg
Purity： 100%
1 week
$1,012.00 $708.00
Pack Size： 10mg
Purity： 100%
1 week
$1,372.00 $960.00
Pack Size： 25mg
Purity： 100%
1 week
$1,989.00 $1,392.00
Pack Size： 50mg
Purity： 100%
1 week
$2,675.00 $1,872.00
Pack Size： 100mg
Purity： 100%
1 week
$3,623.00 $2,536.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BDPO
Chemical Name: HS024
CAS Number: 212370-59-7
Molecular Formula: C58H79N19O10S2
Molecular Weight: 1266.4992
MDL Number: MFCD02179659
SMILES: CCCC[C@@H]1NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCNC(=N)N)Cc1c[nH]cn1)Cc1ccc2c(c1)cccc2)CCCNC(=N)N)Cc1c[nH]c2c1cccc2)C(=O)N)NC(=O)C
Properties
Complexity: 2470  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 8  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 89  
Hydrogen Bond Acceptor Count: 15  
Hydrogen Bond Donor Count: 16  
Isotope Atom Count: 0  
Rotatable Bond Count: 19  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.5  
Literature fold

Title: Melanocortin 4 receptor activation induces brain-derived neurotrophic factor expression in rat astrocytes through cyclic AMP-protein kinase A pathway.

Journal: Molecular and cellular endocrinology20120102

Title: Functional characterization of two melanocortin (MC) receptors in lamprey showing orthology to the MC1 and MC4 receptor subtypes.

Journal: BMC evolutionary biology20070101

Title: Beta-MSH inhibits brain inflammation via MC(3)/(4) receptors and impaired NF-kappaB signaling.

Journal: Journal of neuroimmunology20051201

Title: Alpha-melanocyte-stimulating hormone through melanocortin-4 receptor inhibits nitric oxide synthase and cyclooxygenase expression in the hypothalamus of male rats.

Journal: Neuroendocrinology20040101

Title: Molecular cloning, pharmacological characterization, and brain mapping of the melanocortin 4 receptor in the goldfish: involvement in the control of food intake.

Journal: Endocrinology20030601

Title: Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats.

Journal: The Journal of endocrinology20020601

Title: Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.

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