21306-56-9,MFCD00083182
Catalog No.:AA01EFVB

21306-56-9 | QX 314

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Purity
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5mg
95%
1 week  
$133.00   $93.00
- +
10mg
95%
1 week  
$172.00   $120.00
- +
25mg
95%
1 week  
$263.00   $184.00
- +
50mg
95%
1 week  
$367.00   $257.00
- +
100mg
95%
1 week  
$523.00   $366.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA01EFVB
Chemical Name:
QX 314
CAS Number:
21306-56-9
Molecular Formula:
C16H27BrN2O
Molecular Weight:
343.3024
MDL Number:
MFCD00083182
SMILES:
CC[N+](CC(=O)Nc1c(C)cccc1C)(CC)CC.[Br-]
Properties
Computed Properties
 
Complexity:
268  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  

Literature

Title: Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.

Journal: Anesthesiology 20120801

Title: Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.

Journal: Circulation 20120605

Title: Delayed treatment with lidocaine reduces mouse microglial cell injury and cytokine production after stimulation with lipopolysaccharide and interferon γ.

Journal: Anesthesia and analgesia 20120401

Title: The generation of direction selectivity in the auditory system.

Journal: Neuron 20120308

Title: Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus.

Journal: BMC neuroscience 20120101

Title: α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20111019

Title: Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.

Journal: British journal of pharmacology 20110901

Title: Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831

Title: Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.

Journal: Nature neuroscience 20110703

Title: Characterization of dental nociceptive neurons.

Journal: Journal of dental research 20110601

Title: Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.

Journal: Journal of neurochemistry 20110601

Title: The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro.

Journal: Anesthesiology 20110601

Title: Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110406

Title: Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors.

Journal: Stem cells and development 20110301

Title: Induction of TRPV1 desensitization by a biased receptor agonist.

Journal: Channels (Austin, Tex.) 20110101

Title: Activation of TRPA1 by membrane permeable local anesthetics.

Journal: Molecular pain 20110101

Title: Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.

Journal: PloS one 20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: [Potentials for differential block with local anesthetics].

Journal: Masui. The Japanese journal of anesthesiology 20101101

Title: Active roles of electrically coupled bipolar cell network in the adult retina.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20100707

Title: Selectively targeting pain in the trigeminal system.

Journal: Pain 20100701

Title: Asymmetric rostro-caudal inhibition in the primary olfactory cortex.

Journal: Nature neuroscience 20100501

Title: N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: an in vitro electrophysiological study.

Journal: Synapse (New York, N.Y.) 20100201

Title: Local anesthetic effects on human neutrophil priming and activation.

Journal: Regional anesthesia and pain medicine 20100101

Title: Involvement of nicotinic and muscarinic receptors in the endogenous cholinergic modulation of the balance between excitation and inhibition in the young rat visual cortex.

Journal: Cerebral cortex (New York, N.Y. : 1991) 20091001

Title: Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior.

Journal: Molecular psychiatry 20090701

Title: Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns.

Journal: Journal of neurophysiology 20090701

Title: Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.

Journal: Anesthesiology 20090701

Title: QX-314 produces long-lasting local anesthesia modulated by transient receptor potential vanilloid receptors in mice.

Journal: Anesthesiology 20090701

Title: Homeostatic presynaptic suppression of neuronal network bursts.

Journal: Journal of neurophysiology 20090401

Title: Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic.

Journal: Pharmacology, biochemistry, and behavior 20090101

Title: Pore dilation occurs in TRPA1 but not in TRPM8 channels.

Journal: Molecular pain 20090101

Title: Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20081224

Title: Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.

Journal: The Journal of physiology 20081215

Title: Access and binding of local anesthetics in the closed sodium channel.

Journal: Molecular pharmacology 20081001

Title: Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem.

Journal: Neuron 20080710

Title: Lidocaine increases intracellular sodium concentration through a Na+-H+ exchanger in an identified Lymnaea neuron.

Journal: Anesthesia and analgesia 20080501

Title: Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels.

Journal: Circulation research 20080104

Title: Chillies: out of the frying pan and into the clinic?

Journal: Lancet (London, England) 20071013

Title: Neuroscience: a local route to pain relief.

Journal: Nature 20071004

Title: Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.

Journal: Nature 20071004

Title: Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex.

Journal: Journal of cellular physiology 20070501

Title: Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation.

Journal: The Journal of physiology 20070415

Title: Involvement of persistent Na+ current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus.

Journal: Journal of neurophysiology 20070301

Title: Dendritic calcium spikes induce bi-directional synaptic plasticity in the lateral amygdala.

Journal: Neuropharmacology 20070101

Title: An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons.

Journal: Neuroscience 20060901

Title: Pharmacology of a slowly inactivating outward current in hippocampal CA3 pyramidal neurons.

Journal: Journal of neurophysiology 20060901

Title: Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cells.

Journal: Journal of neurophysiology 20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315

Title: NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20060111

Title: Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue.

Journal: Pflugers Archiv : European journal of physiology 20051201

Title: Behaviorally relevant endocannabinoid action in hippocampus: dependence on temporal summation of multiple inputs.

Journal: Behavioural pharmacology 20050901

Title: Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.

Journal: Journal of neurophysiology 20050501

Title: Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050216

Title: Presenilin attenuates receptor-mediated signaling and synaptic function.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20050209

Title: Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.

Journal: European journal of pain (London, England) 20050201

Title: Membrane bistability in thalamic reticular neurons during spindle oscillations.

Journal: Journal of neurophysiology 20050101

Title: Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.

Journal: Neuropharmacology 20050101

Title: The cortically evoked secondary depolarization affects the integrative properties of thalamic reticular neurons.

Journal: The European journal of neuroscience 20041101

Title: [The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].

Journal: [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20041101

Title: Local anesthetics inhibit thromboxane A2 signaling in Xenopus oocytes and human k562 cells.

Journal: Anesthesia and analgesia 20040901

Title: Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures.

Journal: Journal of neurophysiology 20040801

Title: Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.

Journal: Molecular pharmacology 20040801

Title: Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex.

Journal: The Journal of physiology 20040501

Title: NMDA receptor-mediated depolarizing after-potentials in the basal dendrites of CA1 pyramidal neurons.

Journal: Neuroscience research 20040301

Title: Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones.

Journal: British journal of pharmacology 20030801

Title: Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampus.

Journal: Journal of neurophysiology 20030701

Title: Independent neuronal oscillators of the rat globus pallidus.

Journal: Journal of neurophysiology 20030301

Title: High frequency stimulation-induced dendritic calcium waves in rat hippocampal neurons.

Journal: Neuroscience letters 20021225

Title: Postnatal changes in the overall postsynaptic currents evoked in CA1 pyramidal neurons of the rat hippocampus.

Journal: Life sciences 20021220

Title: Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion.

Journal: Journal of neurophysiology 20020601

Title: Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats.

Journal: Anesthesiology 20020201

Title: Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics.

Journal: Molecular pharmacology 20011201

Title: Development of a behavioral model of TMJ pain in rats: the TMJ formalin test.

Journal: Pain 20011101

Title: Function of NMDA receptors and persistent sodium channels in a feedback pathway of the electrosensory system.

Journal: Journal of neurophysiology 20011001

Title: Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex.

Journal: Journal of neurophysiology 20011001

Title: Electrophysiology of interneurons in the glomerular layer of the rat olfactory bulb.

Journal: Journal of neurophysiology 20011001

Title: Ionic mechanisms underlying burst firing of layer III sensorimotor cortical neurons of the cat: an in vitro slice study.

Journal: Journal of neurophysiology 20010801

Title: Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics.

Journal: British journal of pharmacology 20010501

Title: Enhanced temporal stability of cholinergic hippocampal gamma oscillations following respiratory alkalosis in vitro.

Journal: Journal of neurophysiology 20010501

Title: Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.

Journal: Molecular pharmacology 20010401

Title: Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.

Journal: Pharmacological research 20010401

Title: Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.

Journal: Biophysical journal 20010201

Title: Local anesthetic inhibition of G protein-coupled receptor signaling by interference with Galpha(q) protein function.

Journal: Molecular pharmacology 20010201

Title: Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.

Journal: BMC neuroscience 20010101

Title: Molecular determinants of state-dependent block of Na+ channels by local anesthetics.

Journal: Science (New York, N.Y.) 19940916

Title: Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.

Journal: Brain research 19900604

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Tags:21306-56-9 Molecular Formula|21306-56-9 MDL|21306-56-9 SMILES|21306-56-9 QX 314
Catalog No.: AA01EFVB
21306-56-9,MFCD00083182
21306-56-9 | QX 314
Pack Size: 5mg
Purity: 95%
1 week
$133.00 $93.00
Pack Size: 10mg
Purity: 95%
1 week
$172.00 $120.00
Pack Size: 25mg
Purity: 95%
1 week
$263.00 $184.00
Pack Size: 50mg
Purity: 95%
1 week
$367.00 $257.00
Pack Size: 100mg
Purity: 95%
1 week
$523.00 $366.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA01EFVB
Chemical Name: QX 314
CAS Number: 21306-56-9
Molecular Formula: C16H27BrN2O
Molecular Weight: 343.3024
MDL Number: MFCD00083182
SMILES: CC[N+](CC(=O)Nc1c(C)cccc1C)(CC)CC.[Br-]
Properties
Complexity: 268  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 20  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
Literature fold

Title: Differential effects of peripheral versus central coadministration of QX-314 and capsaicin on neuropathic pain in rats.

Journal: Anesthesiology20120801

Title: Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel Na(v)1.5: a novel mechanism of drug action.

Journal: Circulation20120605

Title: Delayed treatment with lidocaine reduces mouse microglial cell injury and cytokine production after stimulation with lipopolysaccharide and interferon γ.

Journal: Anesthesia and analgesia20120401

Title: The generation of direction selectivity in the auditory system.

Journal: Neuron20120308

Title: Development of synaptic connectivity onto interneurons in stratum radiatum in the CA1 region of the rat hippocampus.

Journal: BMC neuroscience20120101

Title: α7-Containing and non-α7-containing nicotinic receptors respond differently to spillover of acetylcholine.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20111019

Title: Targeting of sodium channel blockers into nociceptors to produce long-duration analgesia: a systematic study and review.

Journal: British journal of pharmacology20110901

Title: Sound rhythms are encoded by postinhibitory rebound spiking in the superior paraolivary nucleus.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110831

Title: Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons.

Journal: Nature neuroscience20110703

Title: Characterization of dental nociceptive neurons.

Journal: Journal of dental research20110601

Title: Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes.

Journal: Journal of neurochemistry20110601

Title: The quaternary lidocaine derivative, QX-314, exerts biphasic effects on transient receptor potential vanilloid subtype 1 channels in vitro.

Journal: Anesthesiology20110601

Title: Use-dependent AMPA receptor block reveals segregation of spontaneous and evoked glutamatergic neurotransmission.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20110406

Title: Long-term self-renewable feeder-free human induced pluripotent stem cell-derived neural progenitors.

Journal: Stem cells and development20110301

Title: Induction of TRPV1 desensitization by a biased receptor agonist.

Journal: Channels (Austin, Tex.)20110101

Title: Activation of TRPA1 by membrane permeable local anesthetics.

Journal: Molecular pain20110101

Title: Acid solution is a suitable medium for introducing QX-314 into nociceptors through TRPV1 channels to produce sensory-specific analgesic effects.

Journal: PloS one20110101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters20101101

Title: [Potentials for differential block with local anesthetics].

Journal: Masui. The Japanese journal of anesthesiology20101101

Title: Active roles of electrically coupled bipolar cell network in the adult retina.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20100707

Title: Selectively targeting pain in the trigeminal system.

Journal: Pain20100701

Title: Asymmetric rostro-caudal inhibition in the primary olfactory cortex.

Journal: Nature neuroscience20100501

Title: N-ethyl lidocaine (QX-314) protects striatal neurons against ischemia: an in vitro electrophysiological study.

Journal: Synapse (New York, N.Y.)20100201

Title: Local anesthetic effects on human neutrophil priming and activation.

Journal: Regional anesthesia and pain medicine20100101

Title: Involvement of nicotinic and muscarinic receptors in the endogenous cholinergic modulation of the balance between excitation and inhibition in the young rat visual cortex.

Journal: Cerebral cortex (New York, N.Y. : 1991)20091001

Title: Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior.

Journal: Molecular psychiatry20090701

Title: Glycine site of NMDA receptor serves as a spatiotemporal detector of synaptic activity patterns.

Journal: Journal of neurophysiology20090701

Title: Coapplication of lidocaine and the permanently charged sodium channel blocker QX-314 produces a long-lasting nociceptive blockade in rodents.

Journal: Anesthesiology20090701

Title: QX-314 produces long-lasting local anesthesia modulated by transient receptor potential vanilloid receptors in mice.

Journal: Anesthesiology20090701

Title: Homeostatic presynaptic suppression of neuronal network bursts.

Journal: Journal of neurophysiology20090401

Title: Nociceptive behavior induced by mustard oil injection into the temporomandibular joint is blocked by a peripheral non-opioid analgesic and a central opioid analgesic.

Journal: Pharmacology, biochemistry, and behavior20090101

Title: Pore dilation occurs in TRPA1 but not in TRPM8 channels.

Journal: Molecular pain20090101

Title: Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20081224

Title: Opposing effects of PSD-93 and PSD-95 on long-term potentiation and spike timing-dependent plasticity.

Journal: The Journal of physiology20081215

Title: Access and binding of local anesthetics in the closed sodium channel.

Journal: Molecular pharmacology20081001

Title: Retrograde GABA signaling adjusts sound localization by balancing excitation and inhibition in the brainstem.

Journal: Neuron20080710

Title: Lidocaine increases intracellular sodium concentration through a Na+-H+ exchanger in an identified Lymnaea neuron.

Journal: Anesthesia and analgesia20080501

Title: Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels.

Journal: Circulation research20080104

Title: Chillies: out of the frying pan and into the clinic?

Journal: Lancet (London, England)20071013

Title: Neuroscience: a local route to pain relief.

Journal: Nature20071004

Title: Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers.

Journal: Nature20071004

Title: Long-term depression requires postsynaptic AMPA GluR2 receptor in adult mouse cingulate cortex.

Journal: Journal of cellular physiology20070501

Title: Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation.

Journal: The Journal of physiology20070415

Title: Involvement of persistent Na+ current in spike initiation in primary sensory neurons of the rat mesencephalic trigeminal nucleus.

Journal: Journal of neurophysiology20070301

Title: Dendritic calcium spikes induce bi-directional synaptic plasticity in the lateral amygdala.

Journal: Neuropharmacology20070101

Title: An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons.

Journal: Neuroscience20060901

Title: Pharmacology of a slowly inactivating outward current in hippocampal CA3 pyramidal neurons.

Journal: Journal of neurophysiology20060901

Title: Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cells.

Journal: Journal of neurophysiology20060501

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Impaired feedforward inhibition of the thalamocortical projection in epileptic Ca2+ channel mutant mice, tottering.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20060315

Title: NMDA receptors in layer 4 spiny stellate cells of the mouse barrel cortex contain the NR2C subunit.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20060111

Title: Pharmacological properties of neuronal TTX-resistant sodium channels and the role of a critical serine pore residue.

Journal: Pflugers Archiv : European journal of physiology20051201

Title: Behaviorally relevant endocannabinoid action in hippocampus: dependence on temporal summation of multiple inputs.

Journal: Behavioural pharmacology20050901

Title: Synaptic depolarizing GABA Response in adults is excitatory and proconvulsive when GABAB receptors are blocked.

Journal: Journal of neurophysiology20050501

Title: Sodium channels in transient retinal bipolar cells enhance visual responses in ganglion cells.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050216

Title: Presenilin attenuates receptor-mediated signaling and synaptic function.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20050209

Title: Evidence for the involvement of endogenous ATP and P2X receptors in TMJ pain.

Journal: European journal of pain (London, England)20050201

Title: Membrane bistability in thalamic reticular neurons during spindle oscillations.

Journal: Journal of neurophysiology20050101

Title: Metabotropic glutamate receptor 2 modulates excitatory synaptic transmission in the rat globus pallidus.

Journal: Neuropharmacology20050101

Title: The cortically evoked secondary depolarization affects the integrative properties of thalamic reticular neurons.

Journal: The European journal of neuroscience20041101

Title: [The filter region of the myocardial Na channel, together with ion selectivity, controls pharmacodynamics of anti-arrhythmia agents--an analysis using the channel altered by idiopathic ventricular fibrillation].

Journal: [Hokkaido igaku zasshi] The Hokkaido journal of medical science20041101

Title: Local anesthetics inhibit thromboxane A2 signaling in Xenopus oocytes and human k562 cells.

Journal: Anesthesia and analgesia20040901

Title: Contribution of intrinsic neuronal factors in the generation of cortically driven electrographic seizures.

Journal: Journal of neurophysiology20040801

Title: Unexpected mexiletine responses of a mutant cardiac Na+ channel implicate the selectivity filter as a structural determinant of antiarrhythmic drug access.

Journal: Molecular pharmacology20040801

Title: Serotonergic facilitation of synaptic activity in the developing rat prefrontal cortex.

Journal: The Journal of physiology20040501

Title: NMDA receptor-mediated depolarizing after-potentials in the basal dendrites of CA1 pyramidal neurons.

Journal: Neuroscience research20040301

Title: Local anaesthetics block hyperpolarization-activated inward current in rat small dorsal root ganglion neurones.

Journal: British journal of pharmacology20030801

Title: Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampus.

Journal: Journal of neurophysiology20030701

Title: Independent neuronal oscillators of the rat globus pallidus.

Journal: Journal of neurophysiology20030301

Title: High frequency stimulation-induced dendritic calcium waves in rat hippocampal neurons.

Journal: Neuroscience letters20021225

Title: Postnatal changes in the overall postsynaptic currents evoked in CA1 pyramidal neurons of the rat hippocampus.

Journal: Life sciences20021220

Title: Intracellular QX-314 causes depression of membrane potential oscillations in lamprey spinal neurons during fictive locomotion.

Journal: Journal of neurophysiology20020601

Title: Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats.

Journal: Anesthesiology20020201

Title: Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics.

Journal: Molecular pharmacology20011201

Title: Development of a behavioral model of TMJ pain in rats: the TMJ formalin test.

Journal: Pain20011101

Title: Function of NMDA receptors and persistent sodium channels in a feedback pathway of the electrosensory system.

Journal: Journal of neurophysiology20011001

Title: Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex.

Journal: Journal of neurophysiology20011001

Title: Electrophysiology of interneurons in the glomerular layer of the rat olfactory bulb.

Journal: Journal of neurophysiology20011001

Title: Ionic mechanisms underlying burst firing of layer III sensorimotor cortical neurons of the cat: an in vitro slice study.

Journal: Journal of neurophysiology20010801

Title: Inhibition of m3 muscarinic acetylcholine receptors by local anaesthetics.

Journal: British journal of pharmacology20010501

Title: Enhanced temporal stability of cholinergic hippocampal gamma oscillations following respiratory alkalosis in vitro.

Journal: Journal of neurophysiology20010501

Title: Structural and gating changes of the sodium channel induced by mutation of a residue in the upper third of IVS6, creating an external access path for local anesthetics.

Journal: Molecular pharmacology20010401

Title: Inhibition of the Na,K-ATPase of canine renal medulla by several local anesthetics.

Journal: Pharmacological research20010401

Title: Ion selectivity filter regulates local anesthetic inhibition of G-protein-gated inwardly rectifying K+ channels.

Journal: Biophysical journal20010201

Title: Local anesthetic inhibition of G protein-coupled receptor signaling by interference with Galpha(q) protein function.

Journal: Molecular pharmacology20010201

Title: Gamma oscillation underlies hyperthermia-induced epileptiform-like spikes in immature rat hippocampal slices.

Journal: BMC neuroscience20010101

Title: Molecular determinants of state-dependent block of Na+ channels by local anesthetics.

Journal: Science (New York, N.Y.)19940916

Title: Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes.

Journal: Brain research19900604

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