213252-19-8,MFCD00953587
Catalog No.:AA00BGM7

213252-19-8 | 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$105.00   $73.00
- +
5mg
98%
in stock  
$274.00   $192.00
- +
25mg
98%
in stock  
$706.00   $494.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA00BGM7
Chemical Name:
5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE
CAS Number:
213252-19-8
Molecular Formula:
C20H17F3N2O4S
Molecular Weight:
438.4202
MDL Number:
MFCD00953587
SMILES:
COc1ccc(cc1C(=O)NCc1ccc(cc1)C(F)(F)F)CC1SC(=O)NC1=O
Properties
Computed Properties
 
Complexity:
653  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0  
XLogP3:
3.7  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).

Journal: Bioorganic & medicinal chemistry letters 20121201

Title: Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists.

Journal: Bioorganic & medicinal chemistry 20110515

Title: Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands.

Journal: The Journal of pharmacology and experimental therapeutics 20041101

Title: Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.

Journal: Journal of medicinal chemistry 20040812

Title: MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities.

Journal: Biochemical and biophysical research communications 20040528

Title: Novel PPARgamma-dependent and independent effects for thiazolidinediones.

Journal: Current opinion in lipidology 20031201

Title: Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.

Journal: Journal of medicinal chemistry 20030814

Title: Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice.

Journal: American journal of physiology. Endocrinology and metabolism 20030501

Title: Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.

Journal: Journal of medicinal chemistry 20030410

Title: MK-767. Kyorin/Banyu/Merck.

Journal: Current opinion in investigational drugs (London, England : 2000) 20030401

Title: Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.

Journal: Bioorganic & medicinal chemistry letters 20020107

Title: [KRP-297, MCC-555].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20011101

Title: Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.

Journal: Journal of medicinal chemistry 20010621

Title: Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists.

Journal: The Biochemical journal 20010115

Title: Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight.

Journal: Biochemical and biophysical research communications 20000510

Title: The PPARs: from orphan receptors to drug discovery.

Journal: Journal of medicinal chemistry 20000224

Title: Amelioration by KRP-297, a new thiazolidinedione, of impaired glucose uptake in skeletal muscle from obese insulin-resistant animals.

Journal: Metabolism: clinical and experimental 19991101

Title: Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha.

Journal: Biochemical and biophysical research communications 19990714

Title: (3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.

Journal: Bioorganic & medicinal chemistry letters 19990222

Title: A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.

Journal: Diabetes 19981201

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Related Products of 213252-19-8
Tags:213252-19-8 Molecular Formula|213252-19-8 MDL|213252-19-8 SMILES|213252-19-8 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE
Catalog No.: AA00BGM7
213252-19-8,MFCD00953587
213252-19-8 | 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE
Pack Size: 1mg
Purity: ≥98%
in stock
$105.00 $73.00
Pack Size: 5mg
Purity: 98%
in stock
$274.00 $192.00
Pack Size: 25mg
Purity: 98%
in stock
$706.00 $494.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA00BGM7
Chemical Name: 5-[(2,4-DIOXO-1,3-THIAZOLIDIN-5-YL)METHYL]-2-METHOXY-N-[4-(TRIFLUOROMETHYL)BENZYL]BENZAMIDE
CAS Number: 213252-19-8
Molecular Formula: C20H17F3N2O4S
Molecular Weight: 438.4202
MDL Number: MFCD00953587
SMILES: COc1ccc(cc1C(=O)NCc1ccc(cc1)C(F)(F)F)CC1SC(=O)NC1=O
Properties
Complexity: 653  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 30  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 1  
Undefined Bond Stereocenter Count: 0  
XLogP3: 3.7  
Literature fold

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters20130801

Title: Design, synthesis and evaluation of novel zwitterionic compounds as PPARα/γ dual agonists (1).

Journal: Bioorganic & medicinal chemistry letters20121201

Title: Biological evaluation of novel benzisoxazole derivatives as PPARδ agonists.

Journal: Bioorganic & medicinal chemistry20110515

Title: Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands.

Journal: The Journal of pharmacology and experimental therapeutics20041101

Title: Peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes.

Journal: Journal of medicinal chemistry20040812

Title: MK-0767, a novel dual PPARalpha/gamma agonist, displays robust antihyperglycemic and hypolipidemic activities.

Journal: Biochemical and biophysical research communications20040528

Title: Novel PPARgamma-dependent and independent effects for thiazolidinediones.

Journal: Current opinion in lipidology20031201

Title: Design, synthesis, and evaluation of substituted phenylpropanoic acid derivatives as human peroxisome proliferator activated receptor activators. Discovery of potent and human peroxisome proliferator activated receptor alpha subtype-selective activators.

Journal: Journal of medicinal chemistry20030814

Title: Combination therapy with PPARgamma and PPARalpha agonists increases glucose-stimulated insulin secretion in db/db mice.

Journal: American journal of physiology. Endocrinology and metabolism20030501

Title: Synthesis and biological and structural characterization of the dual-acting peroxisome proliferator-activated receptor alpha/gamma agonist ragaglitazar.

Journal: Journal of medicinal chemistry20030410

Title: MK-767. Kyorin/Banyu/Merck.

Journal: Current opinion in investigational drugs (London, England : 2000)20030401

Title: Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.

Journal: Bioorganic & medicinal chemistry letters20020107

Title: [KRP-297, MCC-555].

Journal: Nihon rinsho. Japanese journal of clinical medicine20011101

Title: Design and synthesis of 2-methyl-2-[4-(2-[5-methyl-2-aryloxazol-4-yl]ethoxy)phenoxy]propionic acids: a new class of dual PPARalpha/gamma agonists.

Journal: Journal of medicinal chemistry20010621

Title: Fatty-acyl-CoA thioesters inhibit recruitment of steroid receptor co-activator 1 to alpha and gamma isoforms of peroxisome-proliferator-activated receptors by competing with agonists.

Journal: The Biochemical journal20010115

Title: Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight.

Journal: Biochemical and biophysical research communications20000510

Title: The PPARs: from orphan receptors to drug discovery.

Journal: Journal of medicinal chemistry20000224

Title: Amelioration by KRP-297, a new thiazolidinedione, of impaired glucose uptake in skeletal muscle from obese insulin-resistant animals.

Journal: Metabolism: clinical and experimental19991101

Title: Evidence for direct binding of fatty acids and eicosanoids to human peroxisome proliferators-activated receptor alpha.

Journal: Biochemical and biophysical research communications19990714

Title: (3-substituted benzyl)thiazolidine-2,4-diones as structurally new antihyperglycemic agents.

Journal: Bioorganic & medicinal chemistry letters19990222

Title: A novel insulin sensitizer acts as a coligand for peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and PPAR-gamma: effect of PPAR-alpha activation on abnormal lipid metabolism in liver of Zucker fatty rats.

Journal: Diabetes19981201

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