Name: Name:VIRGINIAMYCIN M1
Brand: AABLOCKS
SKU: AA00BC1D
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00BC1D

Chemical Name: VIRGINIAMYCIN M1

CAS Number: 21411-53-0

Molecular Formula: C28H35N3O7

Molecular Weight: 525.5934

MDL Number: MFCD00869411

SMILES: O=C1NC/C=C\C(=C\[C@@H](O)CC(=O)Cc2nc(C(=O)N3C(=CCC3)C(=O)O[C@@H]([C@@H](/C=C/1)C)C(C)C)co2)\C

NSC Number: 87434

Properties

Complexity: 1030

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 3

Defined Bond Stereocenter Count: 3

Formal Charge: 0

Heavy Atom Count: 38

Hydrogen Bond Acceptor Count: 8

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 1

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 2.5

Literature fold

Title: In vitro pharmacokinetic/pharmacodynamic activity of NXL103 versus clindamycin and linezolid against clinical Staphylococcus aureus and Streptococcus pyogenes isolates.

Journal: International journal of antimicrobial agents20111001

Title: Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump.

Journal: International journal of antimicrobial agents20110701

Title: NXL-103, a combination of flopristin and linopristin, for the potential treatment of bacterial infections including community-acquired pneumonia and MRSA.

Journal: Current opinion in investigational drugs (London, England : 2000)20100201

Title: Characterization of pACK4, a mobilizable plasmid from Staphylococcus simulans biovar staphylolyticus.

Journal: Plasmid20091101

Title: ATP hydrolysis and pristinamycin IIA inhibition of the Staphylococcus aureus Vga(A), a dual ABC protein involved in streptogramin A resistance.

Journal: The Journal of biological chemistry20080912

Title: Evidence of a conjugal erythromycin resistance element in the Lyme disease spirochete Borrelia burgdorferi.

Journal: International journal of antimicrobial agents20071201

Title: In vitro activity of telithromycin and quinupristin/dalfopristin against methicillin-resistant coagulase-negative staphylococci with defined resistance genotypes.

Journal: Folia microbiologica20070101

Title: The conformational flexibility of the antibiotic virginiamycin M(1).

Journal: European biophysics journal : EBJ20050701

Title: A new phenotype of resistance to lincosamide and streptogramin A-type antibiotics in Streptococcus agalactiae in New Zealand.

Journal: The Journal of antimicrobial chemotherapy20041201

Title: Solvent affects the conformation of virginiamycin M1 (pristinamycin IIA, streptogramin A).

Journal: Organic & biomolecular chemistry20041021

Title: Streptogramin resistance among Enterococcus faecium isolated from production animals in Denmark in 1997.

Journal: Microbial drug resistance (Larchmont, N.Y.)20020101

Title: Sezonov G, et al. Complete conversion of antibiotic precursor to pristinamycin IIA by overexpression of Streptomyces pristinaespiralis biosynthetic genes. Nat Biotechnol. 1997 Apr;15(4):349-53.

21411-53-0 | VIRGINIAMYCIN M1