Name: Name:CS 7017
Brand: AABLOCKS
SKU: AA00BF12
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00BF12

Chemical Name: CS 7017

CAS Number: 223132-38-5

Molecular Formula: C27H28Cl2N4O4S

Molecular Weight: 575.5066

MDL Number: MFCD13194772

SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)OCc1nc2c(n1C)cc(cc2)Oc1cc(C)c(c(c1)C)N.Cl.Cl

Properties

Complexity: 782

Covalently-Bonded Unit Count: 3

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 38

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 4

Isotope Atom Count: 0

Rotatable Bond Count: 7

Undefined Atom Stereocenter Count: 1

Undefined Bond Stereocenter Count: 0

Literature fold

Title: Correlation between activation of PPARγ and resistin downregulation in a mouse adipocyte cell line by a series of thiazolidinediones.

Journal: Toxicology in vitro : an international journal published in association with BIBRA20130801

Title: The high affinity peroxisome proliferator-activated receptor-gamma agonist RS5444 inhibits both initiation and progression of colon tumors in azoxymethane-treated mice.

Journal: International journal of cancer20080901

Title: Anti-tumour activity of CS-7017, a selective peroxisome proliferator-activated receptor gamma agonist of thiazolidinedione class, in human tumour xenografts and a syngeneic tumour implant model.

Journal: European journal of cancer (Oxford, England : 1990)20080801

Title: RS5444, a novel PPARgamma agonist, regulates aspects of the differentiated phenotype in nontransformed intestinal epithelial cells.

Journal: Molecular and cellular endocrinology20060607

Title: Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1.

Journal: Oncogene20060413

Title: Copland JA, et al. Novel high-affinity PPARgamma agonist alone and in combination with paclitaxel inhibits human anaplastic thyroid carcinoma tumor growth via p21WAF1/CIP1. Oncogene. 2006 Apr 13;25(16):2304-17.

Title: Marlow LA, et al. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb 15;69(4):1536-44.

223132-38-5 | CS 7017