Name: Name:4-Piperidinol, 1-[2-[4-[4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]-
Brand: AABLOCKS
SKU: AA002N9N
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA002N9N

Chemical Name: 4-Piperidinol, 1-[2-[4-[4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]-

CAS Number: 234772-64-6

Molecular Formula: C26H29N5O2

Molecular Weight: 443.5408

MDL Number: MFCD20039929

SMILES: COc1cccc(c1)c1cn(c2c1c(N)ncn2)c1ccc(cc1)CCN1CCC(CC1)O

Properties

Complexity: 608

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 33

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 2

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.7

Literature fold

Title: The integrin antagonist cilengitide activates alphaVbeta3, disrupts VE-cadherin localization at cell junctions and enhances permeability in endothelial cells.

Journal: PloS one20090101

Title: Characterization of anti-apoptotic action of TCDD as a defensive cellular stress response reaction against the cell damaging action of ultra-violet irradiation in an immortalized normal human mammary epithelial cell line, MCF10A.

Journal: Toxicology20060116

Title: Inhibition of Src kinases combined with CD40 ligand blockade prolongs murine cardiac allograft survival.

Journal: Transplantation20051027

Title: Crystal structures of active SRC kinase domain complexes.

Journal: Journal of molecular biology20051021

Title: Modulation of cyclic AMP production by signal transduction pathways in preglomerular microvessels and microvascular smooth muscle cells.

Journal: The Journal of pharmacology and experimental therapeutics20040701

Title: Manganese-induced integrin affinity maturation promotes recruitment of alpha V beta 3 integrin to focal adhesions in endothelial cells: evidence for a role of phosphatidylinositol 3-kinase and Src.

Journal: Thrombosis and haemostasis20040701

Title: Pyrrolopyrimidine c-Src inhibitors reduce growth, adhesion, motility and invasion of prostate cancer cells in vitro.

Journal: European journal of cancer (Oxford, England : 1990)20030901

Title: EGF receptor-mediated, c-Src-dependent, activation of Stat5b is downregulated in mitogenically responsive hepatocytes.

Journal: Journal of cellular physiology20030701

Title: Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells.

Journal: Bone20020101

234772-64-6 | 4-Piperidinol, 1-[2-[4-[4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]-