Name: Name:Paquinimod
Brand: AABLOCKS
SKU: AA00BJKV
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA00BJKV

Chemical Name: Paquinimod

CAS Number: 248282-01-1

Molecular Formula: C21H22N2O3

Molecular Weight: 350.4110

MDL Number: MFCD18633277

SMILES: CCN(C(=O)c1c(O)c2c(CC)cccc2n(c1=O)C)c1ccccc1

Properties

Complexity: 580

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 26

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 4

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.8

Literature fold

Title: Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus.

Journal: Arthritis and rheumatism20120501

Title: Specific effect of immunomodulatory quinoline-3-carboxamide ABR-215757 in GM-CSF stimulated bone marrow cell cultures: block of initiation of proliferation of Gr-1+ cells.

Journal: International immunopharmacology20110801

Title: The impact of a new immunomodulator oxo-quinoline-3-carboxamide on the progression of experimental lupus.

Journal: International immunopharmacology20041101

Title: Synthesis and biological evaluation of new 1,2-dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for treatment of autoimmune disorders: structure-activity relationship.

Journal: Journal of medicinal chemistry20040408

Title: Schelbergen RF, et al. Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis. Ann Rheum Dis. 2015 Dec;74(12):2254-8.

Title: Tahvili S, et al. Paquinimod prevents development of diabetes in the non-obese diabetic (NOD) mouse. PLoS One. 2018 May 9;13(5):e0196598.

Title: Qirui Guo, et al. Induction of alarmin S100A8/A9 mediates activation of aberrant neutrophils in the pathogenesis of COVID-19. Cell Host Microbe. 2021 Feb 10;29(2):222-235.e4.

248282-01-1 | Paquinimod