261619-50-5,MFCD09971085
Catalog No.:AA00C4FS

261619-50-5 | CGS35066

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  • Technical Information
  • Properties
  • Literature
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  • Download SDS
Technical Information
Catalog Number:
AA00C4FS
Chemical Name:
CGS35066
CAS Number:
261619-50-5
Molecular Formula:
C16H16NO6P
Molecular Weight:
349.2751
MDL Number:
MFCD09971085
SMILES:
OC(=O)C(Cc1ccc2c(c1)oc1c2cccc1)NCP(=O)(O)O
Properties
Computed Properties
 
Complexity:
509  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0  
Rotatable Bond Count:
6  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
-0.9  

Literature

Title: Role of Protein Kinase C in Endothelin Converting Enzyme-1 trafficking and shedding from endothelial cells.

Journal: Biochemical and biophysical research communications 20100723

Title: Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.

Journal: Peptides 20100201

Title: Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.

Journal: Journal of medicinal chemistry 20100114

Title: Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats.

Journal: American journal of hypertension 20051201

Title: Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.

Journal: Hypertension (Dallas, Tex. : 1979) 20050701

Title: Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat model.

Journal: Journal of cardiovascular pharmacology 20041101

Title: Triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of chronically instrumented unrestrained conscious spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology 20041101

Title: [Physiological and pathophysiological roles of the endothelin converting enzymes].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040901

Title: Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.

Journal: Clinical science (London, England : 1979) 20020801

Title: Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats.

Journal: Clinical science (London, England : 1979) 20020801

Title: Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).

Journal: Journal of medicinal chemistry 20020328

Title: Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.

Journal: Neuroreport 20020211

Title: Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.

Journal: Journal of medicinal chemistry 20000210

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Tags:261619-50-5 Molecular Formula|261619-50-5 MDL|261619-50-5 SMILES|261619-50-5 CGS35066
Catalog No.: AA00C4FS
261619-50-5,MFCD09971085
261619-50-5 | CGS35066
This product is typically in stock,please click "Inquire" below or contact us at [email protected]for pricing and availability information.
Inquire
Technical Information
Catalog Number: AA00C4FS
Chemical Name: CGS35066
CAS Number: 261619-50-5
Molecular Formula: C16H16NO6P
Molecular Weight: 349.2751
MDL Number: MFCD09971085
SMILES: OC(=O)C(Cc1ccc2c(c1)oc1c2cccc1)NCP(=O)(O)O
Properties
Complexity: 509  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 24  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 4  
Isotope Atom Count: 0  
Rotatable Bond Count: 6  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: -0.9  
Literature fold

Title: Role of Protein Kinase C in Endothelin Converting Enzyme-1 trafficking and shedding from endothelial cells.

Journal: Biochemical and biophysical research communications20100723

Title: Diabetes-associated changes and role of N epsilon-(carboxymethyl)lysine in big ET-1-induced coronary vasoconstriction.

Journal: Peptides20100201

Title: Phosphinic tripeptides as dual angiotensin-converting enzyme C-domain and endothelin-converting enzyme-1 inhibitors.

Journal: Journal of medicinal chemistry20100114

Title: Triple vasopeptidase inhibition normalizes blood pressure in conscious, unrestrained, and spontaneously hypertensive rats.

Journal: American journal of hypertension20051201

Title: Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo.

Journal: Hypertension (Dallas, Tex. : 1979)20050701

Title: Role of the endothelin system in secondary pulmonary hypertension related to air embolism: lessons learned from testing four classes of endothelin blockers in a rat model.

Journal: Journal of cardiovascular pharmacology20041101

Title: Triple vasopeptidase inhibition of angiotensin-converting enzyme/neutral endopeptidase/endothelin-converting enzyme activities on the hemodynamic profile of chronically instrumented unrestrained conscious spontaneously hypertensive rats.

Journal: Journal of cardiovascular pharmacology20041101

Title: [Physiological and pathophysiological roles of the endothelin converting enzymes].

Journal: Nihon rinsho. Japanese journal of clinical medicine20040901

Title: Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.

Journal: Clinical science (London, England : 1979)20020801

Title: Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and spontaneously hypertensive rats.

Journal: Clinical science (London, England : 1979)20020801

Title: Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP).

Journal: Journal of medicinal chemistry20020328

Title: Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor.

Journal: Neuroreport20020211

Title: Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.

Journal: Journal of medicinal chemistry20000210

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