Name: Name:2-Thiophenemethylamine
Brand: AABLOCKS
SKU: AA002UL2
Rating: 90 (10 reviews)

2-Thiophenemethylamine is a versatile compound widely used in organic synthesis for its ability to participate in diverse chemical reactions and form structurally interesting molecules. One of its notable applications is in the preparation of various hybrid molecules and fluorescent sensors. For instance, it has been utilized in the synthesis of a naphthalene-thiophene hybrid molecule, which exhibits unique properties and potential applications in materials science and organic electronics. Additionally, it has been incorporated into a fluorescent Pd^2+ sensor, which is capable of detecting palladium ions with high sensitivity and selectivity, making it useful in analytical chemistry and environmental monitoring. Furthermore, 2-Thiophenemethylamine serves as a key reactant in the synthesis of various bioactive compounds with diverse pharmacological properties. It is involved in the preparation of serotonin 5-HT1A receptor antagonists, which have shown neuroprotective effects against ischemic cell damage, making them potential candidates for the treatment of neurological disorders. Additionally, it participates in the synthesis of triazole-linked-thiophene conjugates, imidazole- and piperonyl-containing thiadiazoles and pyrimidines, which have applications in medicinal chemistry and drug discovery, particularly as inducible oxide synthase dimerization inhibitors. Moreover, 2-Thiophenemethylamine is employed in studies exploring asymmetric reductive amination of ketones catalyzed by organic compounds and metal-free aerobic oxidative coupling of amines to imines. These reactions have significance in synthetic chemistry and the development of novel methodologies for the construction of complex organic molecules. In summary, 2-Thiophenemethylamine is a valuable building block in organic synthesis, playing a crucial role in the preparation of various functional molecules with applications in materials science, analytical chemistry, medicinal chemistry, and organic synthesis. Its versatility and reactivity make it an indispensable tool for chemists across different research fields.

Catalog No.: AA002UL2

27757-85-3 | 2-Thiophenemethylamine

Pack Size： 1g

Purity： 97%

in stock

$6.00 $4.00

Pack Size： 5g

Purity： 97%

in stock

$14.00 $10.00

Pack Size： 10g

Purity： 97%

in stock

$25.00 $18.00

Pack Size： 25g

Purity： 97%

in stock

$32.00 $23.00

Pack Size： 100g

Purity： 97%

in stock

$107.00 $75.00

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Technical Information

Catalog Number: AA002UL2

Chemical Name: 2-Thiophenemethylamine

CAS Number: 27757-85-3

Molecular Formula: C5H7NS

Molecular Weight: 113.1808

MDL Number: MFCD00005460

SMILES: NCc1cccs1

Properties

BP: 194.5°C at 760 mmHg

Form: Liquid

Refractive Index: n20/D 1.5670(lit.)

Solubility: Easily soluble in ethanol and Chloroform.

Stability: Air Sensitive

Storage: Keep in dry area;Room Temperature;

Complexity: 56

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 7

Hydrogen Bond Acceptor Count: 2

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 1

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 0.6

Literature fold

Title: Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy20110901

Title: Synthesis of 4,5,6,7-tetrahydrothieno[3,2-c]pyridines and comparison with their isosteric 1,2,3,4-tetrahydroisoquinolines as inhibitors of phenylethanolamine N-methyltransferase.

Journal: Bioorganic & medicinal chemistry20080101

Title: Amine-guanidine switch: a promising approach to improve DNA binding and antiproliferative activities.

Journal: Journal of medicinal chemistry20071227

Title: (2-Thienylmethyl)ammonium trichlorostannate(II): a hybrid salt.

Journal: Acta crystallographica. Section C, Crystal structure communications20020201

Application fold

2-Thiophenemethylamine is a versatile compound widely used in organic synthesis for its ability to participate in diverse chemical reactions and form structurally interesting molecules.

One of its notable applications is in the preparation of various hybrid molecules and fluorescent sensors. For instance, it has been utilized in the synthesis of a naphthalene-thiophene hybrid molecule, which exhibits unique properties and potential applications in materials science and organic electronics. Additionally, it has been incorporated into a fluorescent Pd^2+ sensor, which is capable of detecting palladium ions with high sensitivity and selectivity, making it useful in analytical chemistry and environmental monitoring.

Furthermore, 2-Thiophenemethylamine serves as a key reactant in the synthesis of various bioactive compounds with diverse pharmacological properties. It is involved in the preparation of serotonin 5-HT1A receptor antagonists, which have shown neuroprotective effects against ischemic cell damage, making them potential candidates for the treatment of neurological disorders. Additionally, it participates in the synthesis of triazole-linked-thiophene conjugates, imidazole- and piperonyl-containing thiadiazoles and pyrimidines, which have applications in medicinal chemistry and drug discovery, particularly as inducible oxide synthase dimerization inhibitors.

Moreover, 2-Thiophenemethylamine is employed in studies exploring asymmetric reductive amination of ketones catalyzed by organic compounds and metal-free aerobic oxidative coupling of amines to imines. These reactions have significance in synthetic chemistry and the development of novel methodologies for the construction of complex organic molecules.

In summary, 2-Thiophenemethylamine is a valuable building block in organic synthesis, playing a crucial role in the preparation of various functional molecules with applications in materials science, analytical chemistry, medicinal chemistry, and organic synthesis. Its versatility and reactivity make it an indispensable tool for chemists across different research fields.